Laura Kelley and colleagues from the Sherwood Lab show that invasive cells adapt their invasion program in the absence of matrix metalloproteinase enzymes, explaining the failure of cancer clinical trials targeting these enzymes.  Described by Prof. Sherwood as "very cool," the reults "could lead to better ways to prevent metastasis, the spread of the disease responsible for 90 percent of cancer deaths" (Science Daily, 24 January 2019).  Congrats, Sherwood Lab for showing how basic science goes to work!  And kudos to Laura, whose image was selected for the cover of the journal issue.