Xinnian Dong

Arts and Sciences Distinguished Professor of Biology

Office: 
4213 French Family Science Center, Durham, NC 27708
Campus Box: 
Box 90338, Durham, NC 27708-1000
Phone: 
(919) 613-8176
Email: 
xdong@duke.edu
Xinnian Dong
Using Arabidopsis thaliana as a model system, my laboratory studies the mechanisms of plant defense against microbial pathogens. We focus on a specific response known as systemic acquired resistance (SAR). SAR, which can be induced by a local infection, provides the plants with long lasting, systemic resistance against a broad spectrum of pathogens. Salicylic acid (SA; an active ingredient of aspirin) has been found to be the endogenous signal of SAR. Using a genetic approach, our laboratory identified genes involved in the regulation of SAR. Molecular and genetic analyses are being carried out to understand the gene function and to elucidate the SAR signaling pathway. These SAR-regulating genes are also favorite targets for molecular engineering of disease-resistance crops.

Education

  • Ph.D., Northwestern University 1988

  • B.S., National Wuhan University 1982

Yoo, Heejin, George H. Greene, Meng Yuan, Guoyong Xu, Derek Burton, Lijing Liu, Jorge Marqués, and Xinnian Dong. “Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity.” Molecular Plant 13, no. 1 (January 2020): 88–98. https://doi.org/10.1016/j.molp.2019.09.009. Full Text

Li, Meina, Lijun Cao, Musoki Mwimba, Yan Zhou, Ling Li, Mian Zhou, Patrick S. Schnable, Jamie A. O’Rourke, Xinnian Dong, and Wei Wang. “Comprehensive mapping of abiotic stress inputs into the soybean circadian clock.” Proceedings of the National Academy of Sciences of the United States of America 116, no. 47 (November 2019): 23840–49. https://doi.org/10.1073/pnas.1708508116. Full Text

Mwimba, Musoki, Sargis Karapetyan, Lijing Liu, Jorge Marqués, Erin M. McGinnis, Nicolas E. Buchler, and Xinnian Dong. “Daily humidity oscillation regulates the circadian clock to influence plant physiology.” Nature Communications 9, no. 1 (October 16, 2018): 4290. https://doi.org/10.1038/s41467-018-06692-2. Full Text

Greene, George H., and Xinnian Dong. “To grow and to defend.” Science (New York, N.Y.) 361, no. 6406 (September 2018): 976–77. https://doi.org/10.1126/science.aau9065. Full Text

Karapetyan, Sargis, and Xinnian Dong. “Redox and the circadian clock in plant immunity: A balancing act.” Free Radical Biology & Medicine 119 (May 2018): 56–61. https://doi.org/10.1016/j.freeradbiomed.2017.12.024. Full Text

Withers, John, and Xinnian Dong. “Post-translational regulation of plant immunity.” Current Opinion in Plant Biology 38 (August 2017): 124–32. https://doi.org/10.1016/j.pbi.2017.05.004. Full Text Open Access Copy

Gu, Yangnan, Raul Zavaliev, and Xinnian Dong. “Membrane Trafficking in Plant Immunity.” Molecular Plant 10, no. 8 (August 2017): 1026–34. https://doi.org/10.1016/j.molp.2017.07.001. Full Text Open Access Copy

Xu, Guoyong, Meng Yuan, Chaoren Ai, Lijing Liu, Edward Zhuang, Sargis Karapetyan, Shiping Wang, and Xinnian Dong. “uORF-mediated translation allows engineered plant disease resistance without fitness costs.” Nature 545, no. 7655 (May 17, 2017): 491–94. https://doi.org/10.1038/nature22372. Full Text

Xu, Guoyong, George H. Greene, Heejin Yoo, Lijing Liu, Jorge Marqués, Jonathan Motley, and Xinnian Dong. “Global translational reprogramming is a fundamental layer of immune regulation in plants.” Nature 545, no. 7655 (May 17, 2017): 487–90. https://doi.org/10.1038/nature22371. Full Text Open Access Copy

Mwimba, Musoki, and Xinnian Dong. “The CAT(2) Comes Back.” Cell Host & Microbe 21, no. 2 (February 2017): 125–27. https://doi.org/10.1016/j.chom.2017.01.012. Full Text

Pages

DONG, X., S. A. BOWLING, and H. CAO. “GENETIC DISSECTION OF THE SAR SIGNAL-TRANSDUCTION PATHWAY(S) IN ARABIDOPSIS.” In Journal of Cellular Biochemistry, 486–486. WILEY-LISS, 1995.

Selected Grants

Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Elucidation of translational regulatory mechanisms of plant immune responses awarded by National Science Foundation (Principal Investigator). 2017 to 2021

Salicylic acid in immunity and health: A small phytohormone with big physiological impacts awarded by National Institutes of Health (Principal Investigator). 2016 to 2021

Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020

Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020

Characterization of the Arabidopsis tRNAome in Pathogen Triggered Immunity awarded by National Institutes of Health (Principal Investigator). 2017 to 2019

Innovation Corps - National Innovation Network Teams Program (I-CorpsTM Teams) awarded by National Science Foundation (Principal Investigator). 2017 to 2019

Dynamic regulation of salicylic acid biosynthesis and perception in plant immunity awarded by National Institutes of Health (Principal Investigator). 2004 to 2018

Gordon and Betty Moore Foundation awarded by (Principal Investigator). 2011 to 2017

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