David R. Sherwood
Nutritional Regulation of Late Larval Development In collaboration with Dr. Ryan Baugh's lab, we are examining the developmental response of late larvae to starvation. We have identified specific developmental checkpoints that larvae enter in response to the absence of food. These studies have many fascinating implications in our understanding of how cells arrest at specific developmental time-points, how an organism and cells enter and exit quiescent states, and how these impinge on life-span.
Members of our group are trained in a diverse range of scientific approaches and join a vibrant scientific community at Duke University, the Research Triangle region and the worldwide group of worm researchers.
Ph.D., Duke University 1997
B.A., Wesleyan University 1990
Gordon, Kacy L., Jay W. Zussman, Xin Li, Camille Miller, and David R. Sherwood. “Stem cell niche exit in C. elegans via orientation and segregation of daughter cells by a cryptic cell outside the niche.” Elife 9 (July 21, 2020). https://doi.org/10.7554/elife.56383. Full Text
Keeley, Daniel P., Eric Hastie, Ranjay Jayadev, Laura C. Kelley, Qiuyi Chi, Sara G. Payne, Jonathan L. Jeger, Brenton D. Hoffman, and David R. Sherwood. “Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding.” Developmental Cell 54, no. 1 (July 2020): 60-74.e7. https://doi.org/10.1016/j.devcel.2020.05.022. Full Text
Chen, David, Eric Hastie, and David Sherwood. “Endogenous expression of UNC-59/Septin in C. elegans.” Micropublication Biology 2019 (December 20, 2019). https://doi.org/10.17912/micropub.biology.000200. Full Text
Hartman, Jessica H., Christopher T. Richie, Kacy L. Gordon, Danielle F. Mello, Priscila Castillo, April Zhu, Yun Wang, et al. “MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa.” European Journal of Cell Biology 98, no. 5–8 (December 2019): 151043. https://doi.org/10.1016/j.ejcb.2019.05.002. Full Text
Jayadev, Ranjay, Qiuyi Chi, Daniel P. Keeley, Eric L. Hastie, Laura C. Kelley, and David R. Sherwood. “α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes.” The Journal of Cell Biology 218, no. 9 (September 2019): 3098–3116. https://doi.org/10.1083/jcb.201903124. Full Text
Sherwood, David R. “Breaching the Basement Membrane David R. Sherwood.” Developmental Cell 49, no. 4 (May 20, 2019): 498–498.
Gordon, Kacy L., Sara G. Payne, Lara M. Linden-High, Ariel M. Pani, Bob Goldstein, E Jane Albert Hubbard, and David R. Sherwood. “Ectopic Germ Cells Can Induce Niche-like Enwrapment by Neighboring Body Wall Muscle.” Current Biology : Cb 29, no. 5 (March 2019): 823-833.e5. https://doi.org/10.1016/j.cub.2019.01.056. Full Text
Kelley, Laura C., Qiuyi Chi, Rodrigo Cáceres, Eric Hastie, Adam J. Schindler, Yue Jiang, David Q. Matus, Julie Plastino, and David R. Sherwood. “Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs.” Developmental Cell 48, no. 3 (February 2019): 313-328.e8. https://doi.org/10.1016/j.devcel.2018.12.018. Full Text
Keeley, Daniel P., and David R. Sherwood. “Tissue linkage through adjoining basement membranes: The long and the short term of it.” Matrix Biology : Journal of the International Society for Matrix Biology 75–76 (January 2019): 58–71. https://doi.org/10.1016/j.matbio.2018.05.009. Full Text
Hibshman, Jonathan D., Tess C. Leuthner, Chelsea Shoben, Danielle F. Mello, David R. Sherwood, Joel N. Meyer, and L Ryan Baugh. “Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans.” American Journal of Physiology. Cell Physiology 315, no. 6 (December 2018): C781–92. https://doi.org/10.1152/ajpcell.00109.2018. Full Text
Garde, A., Y. Li, and D. R. Sherwood. “The role of lipid metabolism in anchor cell invasion in C.elegans.” In Molecular Biology of the Cell, 29:238–39. AMER SOC CELL BIOLOGY, 2018.
Hartman, Jessica Helene, Kacy L. Gordon, David R. Sherwood, and Joel N. Meyer. “HUMANIZED, TRANSGENIC WORMS TO STUDY THE ROLE OF MITOCHONDRIAL CYP2E1 IN TOXICANT-INDUCED MITOCHONDRIAL DYSFUNCTION AND NEURODEGENERATION.” In Drug Metabolism and Pharmacokinetics, 33:S35–S35. JAPANESE SOC STUDY XENOBIOTICS, 2018.
Caceres, R., N. Bojanala, L. C. Kelley, J. Dreier, J. Manzi, F. Di Federico, Q. Chi, et al. “WASP and WAVE activate the Arp2/3 complex for actin-based force production during basement membrane invasion.” In Molecular Biology of the Cell, Vol. 28. AMER SOC CELL BIOLOGY, 2017.
Keeley, D. P., and D. R. Sherwood. “Type IV Collagen stabilizes the connection of juxtaposed tissues at the B-LINK complex.” In Molecular Biology of the Cell, Vol. 27. AMER SOC CELL BIOLOGY, 2016.
Naegeli, K. M., Q. Chi, and D. R. Sherwood. “Rapid exocytosis of an endolysosome-derived membrane domain forms a polarized invasive protrusion that clears basement membrane during cell invasion.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.
Jayadev, R., and D. R. Sherwood. “Visualizing and elucidating the regulation of type IV collagen assembly in developing basement membranes.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.
Clay, M. R., LR Lilley Lohmer, J. W. Ziel, Q. Chi, and D. R. Sherwood. “Cell invasion through basement membrane requires multiple GTPases and is initiated by CDC-42 directed invadopodia formation.” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.
Matus, D. Q., L. L. Lohmer, L. C. Kelley, and D. R. Sherwood. “Cell cycle arrest is required for cell invasive behavior.” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.
Keeley, D. P., M. Morrissey, and D. R. Sherwood. “Investigating the B-LINK: an adhesion system that links neighboring basement membranes.” In Molecular Biology of the Cell, Vol. 25. AMER SOC CELL BIOLOGY, 2014.
Schindler, A. J., L. R. Baugh, and D. R. Sherwood. “Identification of two novel insulin- and hormone-regulated nutritional checkpoints in C. elegans development.” In Integrative and Comparative Biology, 54:E185–E185. OXFORD UNIV PRESS INC, 2014.
Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025
Pharmacological Sciences Training Grant awarded by National Institutes of Health (Preceptor). 2020 to 2025
A comprehensive toolkit to visualize endogenously tagged fluorescent basement membrane components in a living animal awarded by National Institutes of Health (Principal Investigator). 2020 to 2022
Understanding the role of the collagen receptor DDR-2 in germ stem cell niche formation awarded by National Institutes of Health (Principal Investigator). 2019 to 2022
Understanding how cells invade through basement membrane in vivo awarded by National Institutes of Health (Principal Investigator). 2016 to 2021
Connecting human disease to basement membrane biology awarded by University of Manchester (Principal Investigator). 2019 to 2020
Transmission electron microscope (TEM) awarded by National Institutes of Health (Minor User). 2019 to 2020
Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020
Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020
Defining a Newly Identified Membrane Structure That Directs Cell Invasion awarded by American Cancer Society, Inc. (Principal Investigator). 2016 to 2019