David R. Sherwood
Nutritional Regulation of Late Larval Development In collaboration with Dr. Ryan Baugh's lab, we are examining the developmental response of late larvae to starvation. We have identified specific developmental checkpoints that larvae enter in response to the absence of food. These studies have many fascinating implications in our understanding of how cells arrest at specific developmental time-points, how an organism and cells enter and exit quiescent states, and how these impinge on life-span.
Members of our group are trained in a diverse range of scientific approaches and join a vibrant scientific community at Duke University, the Research Triangle region and the worldwide group of worm researchers.
Ph.D., Duke University 1997
B.A., Wesleyan University 1990
Gordon, KL, Payne, SG, Linden-High, LM, Pani, AM, Goldstein, B, Hubbard, EJA, and Sherwood, DR. "Ectopic Germ Cells Can Induce Niche-like Enwrapment by Neighboring Body Wall Muscle." Current Biology : Cb 29, no. 5 (March 2019): 823-833.e5. Full Text
Kelley, LC, Chi, Q, Cáceres, R, Hastie, E, Schindler, AJ, Jiang, Y, Matus, DQ, Plastino, J, and Sherwood, DR. "Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs." Developmental Cell 48, no. 3 (February 2019): 313-328.e8. Full Text
Keeley, DP, and Sherwood, DR. "Tissue linkage through adjoining basement membranes: The long and the short term of it." Matrix Biology : Journal of the International Society for Matrix Biology 75-76 (January 2019): 58-71. (Review) Full Text
Hibshman, JD, Leuthner, TC, Shoben, C, Mello, DF, Sherwood, DR, Meyer, JN, and Baugh, LR. "Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans." American Journal of Physiology. Cell Physiology 315, no. 6 (December 2018): C781-C792. Full Text
Cáceres, R, Bojanala, N, Kelley, LC, Dreier, J, Manzi, J, Di Federico, F, Chi, Q, Risler, T, Testa, I, Sherwood, DR, and Plastino, J. "Forces drive basement membrane invasion in Caenorhabditis elegans." Proceedings of the National Academy of Sciences of the United States of America 115, no. 45 (November 2018): 11537-11542. Full Text
Hartman, JH, Smith, LL, Gordon, KL, Laranjeiro, R, Driscoll, M, Sherwood, DR, and Meyer, JN. "Swimming Exercise and Transient Food Deprivation in Caenorhabditis elegans Promote Mitochondrial Maintenance and Protect Against Chemical-Induced Mitotoxicity." Scientific Reports 8, no. 1 (May 29, 2018): 8359-null. Full Text Open Access Copy
Sherwood, DR, and Plastino, J. "Invading, Leading and Navigating Cells in Caenorhabditis elegans: Insights into Cell Movement in Vivo." Genetics 208, no. 1 (January 2018): 53-78. (Review) Full Text
Naegeli, KM, Hastie, E, Garde, A, Wang, Z, Keeley, DP, Gordon, KL, Pani, AM, Kelley, LC, Morrissey, MA, Chi, Q, Goldstein, B, and Sherwood, DR. "Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain." Developmental cell 43, no. 4 (November 2017): 403-417.e10. Full Text
Kelley, LC, Wang, Z, Hagedorn, EJ, Wang, L, Shen, W, Lei, S, Johnson, SA, and Sherwood, DR. "Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans." Nature protocols 12, no. 10 (October 2017): 2081-2096. Full Text
Linden, LM, Gordon, KL, Pani, AM, Payne, SG, Garde, A, Burkholder, D, Chi, Q, Goldstein, B, and Sherwood, DR. "Identification of regulators of germ stem cell enwrapment by its niche in C. elegans." Developmental Biology 429, no. 1 (September 2017): 271-284. Full Text
Caceres, R, Bojanala, N, Kelley, LC, Dreier, J, Manzi, J, Di Federico, F, Chi, Q, Risler, T, Testa, I, Sherwood, DR, and Plastino, J. "WASP and WAVE activate the Arp2/3 complex for actin-based force production during basement membrane invasion." 2017.
Keeley, DP, and Sherwood, DR. "Type IV Collagen stabilizes the connection of juxtaposed tissues at the B-LINK complex." 2016.
Naegeli, KM, Chi, Q, and Sherwood, DR. "Rapid exocytosis of an endolysosome-derived membrane domain forms a polarized invasive protrusion that clears basement membrane during cell invasion." 2015.
Jayadev, R, and Sherwood, DR. "Visualizing and elucidating the regulation of type IV collagen assembly in developing basement membranes." 2015.
Clay, MR, Lohmer, LRL, Ziel, JW, Chi, Q, and Sherwood, DR. "Cell invasion through basement membrane requires multiple GTPases and is initiated by CDC-42 directed invadopodia formation." December 2014.
Matus, DQ, Lohmer, LL, Kelley, LC, and Sherwood, DR. "Cell cycle arrest is required for cell invasive behavior." December 2014.
Keeley, DP, Morrissey, M, and Sherwood, DR. "Investigating the B-LINK: an adhesion system that links neighboring basement membranes." December 2014.
Schindler, AJ, Baugh, LR, and Sherwood, DR. "Identification of two novel insulin- and hormone-regulated nutritional checkpoints in C. elegans development." 2014.
Matus, DQ, Chang, E, Makohon-Moore, SC, and Sherwood, DR. "Targeted cell cycle arrest halts basement membrane gap expansion during nematode uterine-vulval attachment." 2014.
Chang, E, Yang, M, Sherwood, DR, and Matus, DQ. "The evolution of anchor cell invasion during rhabditid nematode vulval development." April 2013.
Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (PD/PI). 2001 to 2022
Understanding the role of the collagen receptor DDR-2 in germ stem cell niche formation awarded by National Institutes of Health (Principal Investigator). 2019 to 2022
Understanding how cells invade through basement membrane in vivo awarded by National Institutes of Health (Principal Investigator). 2016 to 2021
Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020
Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020
Defining a Newly Identified Membrane Structure That Directs Cell Invasion awarded by American Cancer Society, Inc. (Principal Investigator). 2016 to 2019
Understanding how innexins direct stem cell niche morphology awarded by National Institutes of Health (Principal Investigator). 2016 to 2018
Visualizing and Elucidating the Role of Force on Type IV Collagen in Development awarded by National Institutes of Health (Principal Investigator). 2016 to 2018
Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health (Major User). 2016 to 2018
Elucidating Key Mechanisms Regulating Cell Invasion In Vivo awarded by National Institutes of Health (Principal Investigator). 2007 to 2017