This course will bring students into a basic research setting to directly contribute to our understanding of the molecular and cellular underpinnings of neurodegenerative disease. Classic experimental approaches in the lab (fruit fly genetics, molecular techniques, dissection, immunocytochemistry, microscopy) will be paired with short lectures, literature-based discussions, and data presentations.
Genetic perspectives on primate evolution. Interpretation of molecular data in understanding primate origins, historical and present-day distributions, and natural selection. Topics include: the genetic signature of pathogen pressure; population differentiation and local adaptation to ecological differences; genetic signatures of admixture, including in the human lineage; molecular marker-based tests of kin-biased behavior and paternal care; primate behavioral genetics and genomics; phylogenetic methods to investigate the evolution of primate social structures; conservation genetics.
Explores ecosystems in the deep sea, including fundamental aspects of geology, chemistry, and biodiversity;behavioral, physiological, and biochemical adaptations of organisms (primarily invertebrate, but may include microbial and vertebrate components) to deep-sea benthic and bentho-paelagic environments will be introduced. Students will gain an understanding of the ecosystem services of the deep sea; issues in deep-sea environmental management arising from exploitation of deep-sea resources will be discussed. For undergraduates only.
Symbiotic interactions are integral to the biology of multicellular eukaryotes. The discovery of the roles of the human microbiome in the development, physiology, ecology and evolution of humans is currently transforming medicine. This course is a multidisciplinary study, at the intersection of evolutionary biology, ecology and genomics, of symbiotic systems such as plant-animal, microbe-plant, and microbe-animal symbioses spanning the entire tree of life, including the human microbiome.
Gain skills necessary to conduct neuroscience research and integrate findings from multiple levels of analysis (molecular, cellular and behavioral). Team-based learning format and collaboration with neuroscience lab to generate, analyze, and communicate novel scientific findings. Experimentation will occur in a model organism and may include PCR, live cell imaging and/or behavioral conditioning experiments. Prerequisite: Neuroscience 101.
An exploration of how we have come to understand the relationships between genes and traits, with a focus on traits of biomedical importance. We explore how physiological systems biology can be used to understand the causal pathways by which genes affect traits. Examples will be taken largely from the biomedical literature with a focus on genetic diseases and the roles of genetic background and environment in determining how (and why) genes affect traits. Readings and class participation, short papers and oral presentations on research projects. Nijhout
Survey of new advances in the field of environmental and evolu- tionary microbiology, based on current literature, discussion, and laboratory exercises. Topics to include bacterial phylogeny, molecular ecology, emerging infectious diseases, bacterial symbiosis, experimental evolution, evolution of drug resistance, and microbial genomics. Prerequisite: Biology 20 or 212L or 201L or 202L. One course. 4 graduate units.
One course. 3 graduate units.
Processes responsible for natural biodiversity from popula- tions to the globe. Topics include species interactions (e.g., competition, predation, parasitism), natural and human disturbance, climate change, and implications for management and conservation. Lab section involving observation and data from large-scale manipulations, such as experimental hurricanes, fire, and herbivore exclosures. One course. 3 graduate units.
Distribution and density of marine and semi-terrestrial tropical invertebrate populations; behavioral and mechanical adaptations to physical stress, competition, and predation using rapid empirical approaches and hypothesis testing. Offered only at Beaufort, with preparation for fieldwork before and analysis and presentation of projects after required one week intensive field experience on the coast of Panama. Consent of instructor required. Half course. 2 graduate units.