Zhen-Ming Pei

Associate Professor of Biology

3102 Ffsc, Duke University, Durham, NC 27708-1000
Campus Box: 
Box 90338, Duke University, Durham, NC 27708-1000
(919) 613-8152
My laboratory is interested in the early signaling events by which plants sense environmental signals and decode to give the appropriate responses. Upon perception of external signals, cell surface receptors trigger an increase in cytosolic free calcium concentration, which is mediated by ion channels. Our long-term goals are to identify these receptors and ion channels, isolate their interacting components, and assign molecular functions to them. Currently, we are using multidisciplinary approaches of biophysics, biochemistry, cell biology, molecular genetics, and function genomics to dissect the signaling cascades of external calcium as well as nitric oxide in the model plant Arabidopsis.


  • Ph.D., Shanghai Institute of Plant Physiology (China) 1993

  • M.S., Fudan University (China) 1990

  • B.S., Lanzhou University (China) 1985

Pei, Z. M., and S. Gilroy. “Calcium Signals and Their Regulation” 33 (February 9, 2009): 137–62. https://doi.org/10.1002/9781444302387.ch5. Full Text

Ru, Qiao-Mei, Zhen-Ming Pei, and Hai-Lei Zheng. “[In vitro studies on antioxidant and antimicrobial activities of polysaccharide from Lycoris aurea].Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials 31, no. 10 (October 2008): 1536–40.

Liu, W. Z., R. J. Zhang, Z. M. Pei, and Y. K. He. “The signal transduction of nitric oxide in plants.” Prog Nat Sci 18, no. 1 (2008): 10–24.

Tang, Ru-Hang, Shengcheng Han, Hailei Zheng, Charles W. Cook, Christopher S. Choi, Todd E. Woerner, Robert B. Jackson, and Zhen-Ming Pei. “Coupling diurnal cytosolic Ca2+ oscillations to the CAS-IP3 pathway in Arabidopsis.Science (New York, N.Y.) 315, no. 5817 (March 2007): 1423–26. https://doi.org/10.1126/science.1134457. Full Text

Zhao, Xin, Zhen-Ming Pei, and Yi-Kun He. “[Extracellular Ca2+ signaling: first messenger in animals and plants].Yi Chuan = Hereditas 29, no. 3 (March 2007): 269–75. https://doi.org/10.1360/yc-007-0269. Full Text

Qiang, X., R. Qiaomei, W. Feihua, H. Xuan, P. Zhenming, and Z. Hailei. “Nitric Oxide Alleviates Oxidative Stress Caused by Lanthanum in Rice Leaves.” Journal of Rare Earths 25, no. 5 (January 1, 2007): 631–36. https://doi.org/10.1016/S1002-0721(07)60576-6. Full Text

Pei, Z. M., and K. Kuchitsu. “Early ABA signaling events in guard cells.” Journal of Plant Growth Regulation 24, no. 4 (December 1, 2005): 296–307. https://doi.org/10.1007/s00344-005-0095-x. Full Text

He, Yikun, Ru-Hang Tang, Yi Hao, Robert D. Stevens, Charles W. Cook, Sun M. Ahn, Liufang Jing, et al. “Nitric oxide represses the Arabidopsis floral transition.Science 305, no. 5692 (September 24, 2004): 1968–71. https://doi.org/10.1126/science.1098837. Full Text

Han, Shengcheng, Ruhang Tang, Lisa K. Anderson, Todd E. Woerner, and Zhen-Ming Pei. “A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells.Nature 425, no. 6954 (September 2003): 196–200. https://doi.org/10.1038/nature01932. Full Text

Kwak, June M., Izumi C. Mori, Zhen-Ming Pei, Nathalie Leonhardt, Miguel Angel Torres, Jeffery L. Dangl, Rachel E. Bloom, Sara Bodde, Jonathan D. G. Jones, and Julian I. Schroeder. “NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in Arabidopsis.The Embo Journal 22, no. 11 (June 2003): 2623–33. https://doi.org/10.1093/emboj/cdg277. Full Text