Tai-ping Sun

Professor of Biology

Office: 
3104 French Family Science Center, Durham, NC 27708
Campus Box: 
Box 90338, Durham, NC 27708-0338
Phone: 
(919) 613-8166
The diterpenoid phytohormone gibberellin (GA) plays pivotal roles in regulating growth and development throughout the life cycle of higher plants. Mutations affecting GA biosynthesis or GA response were the key to control plant stature in wheat and rice that led to dramatically increased grain yield and contributed greatly to the success of the ‘Green Revolution’ in the 1960s. Although the GA biosynthetic pathway had been characterized biochemically, little was known about the sites of GA production and the mode of GA action. By multi-faceted approaches using the model system Arabidopsis, my lab has made major breakthroughs in revealing the sites and regulatory mechanisms of GA biosynthesis. We also elucidated the conserved molecular events of GA perception and the early GA signaling pathway. We identified the nuclear transcriptional regulators DELLA proteins, which function as master growth repressors by inhibiting all aspects of GA responses. Binding of GA to its nuclear receptor GID1 enhances the GID1-DELLA interaction, which in turn leads to the rapid proteolysis of DELLA through the ubiquitin-proteasome pathway, and allows transcriptional reprogramming of GA-responsive genes. We and other researchers further showed that GA-GID1-DELLA is a key regulatory module that controls plant growth by integrating internal developmental cues, and external biotic and abiotic signals (light, cold, salt and pathogen stresses). Surprisingly, we recently found that DELLA directly interacts with multiple classes of key regulatory proteins in other signaling pathways. Our work is revealing the complex regulatory network between the GA pathway and other pathways to control plant growth and development.

Education

  • Ph.D., Duke University 1987

  • B.S., National Tsing Hua University (Taiwan) 1980

Dill, A., and T. Sun. “Synergistic derepression of gibberellin signaling by removing RGA and GAI function in Arabidopsis thaliana.Genetics 159, no. 2 (October 2001): 777–85.

Silverstone, A. L., H. S. Jung, A. Dill, H. Kawaide, Y. Kamiya, and T. P. Sun. “Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis.The Plant Cell 13, no. 7 (July 2001): 1555–66. https://doi.org/10.1105/tpc.010047. Full Text

Sun, T. “Gibberellin signal transduction.Current Opinion in Plant Biology 3, no. 5 (October 2000): 374–80. https://doi.org/10.1016/s1369-5266(00)00099-6. Full Text

Silverstone, A. L., and T. Sun. “Gibberellins and the Green Revolution.Trends in Plant Science 5, no. 1 (January 2000): 1–2. https://doi.org/10.1016/s1360-1385(99)01516-2. Full Text

Yamaguchi, S., M. W. Smith, R. G. Brown, Y. Kamiya, and T. Sun. “Phytochrome regulation and differential expression of gibberellin 3beta-hydroxylase genes in germinating Arabidopsis seeds.The Plant Cell 10, no. 12 (December 1998): 2115–26. https://doi.org/10.1105/tpc.10.12.2115. Full Text

Yamaguchi, S., T. P. Sun, H. Kawaide, and Y. Kamiya. “The GA2 locus of Arabidopsis thaliana encodes ent-kaurene synthase of gibberellin biosynthesis.Plant Physiology 116, no. 4 (April 1998): 1271–78. https://doi.org/10.1104/pp.116.4.1271. Full Text

Silverstone, A. L., C. N. Ciampaglio, and T. Sun. “The Arabidopsis RGA gene encodes a transcriptional regulator repressing the gibberellin signal transduction pathway.The Plant Cell 10, no. 2 (February 1998): 155–69. https://doi.org/10.1105/tpc.10.2.155. Full Text

Sun, T. P., and Y. Kamiya. “Regulation and cellular localization of ent-kaurene synthesis.” Physiologia Plantarum 101, no. 4 (December 1, 1997): 701–8. https://doi.org/10.1034/j.1399-3054.1997.1010405.x. Full Text

Silverstone, A. L., P. Y. Mak, E. C. Martínez, and T. P. Sun. “The new RGA locus encodes a negative regulator of gibberellin response in Arabidopsis thaliana.Genetics 146, no. 3 (July 1997): 1087–99.

Silverstone, A. L., C. Chang, E. Krol, and T. P. Sun. “Developmental regulation of the gibberellin biosynthetic gene GA1 in Arabidopsis thaliana.The Plant Journal : For Cell and Molecular Biology 12, no. 1 (July 1997): 9–19. https://doi.org/10.1046/j.1365-313x.1997.12010009.x. Full Text

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