Tai-ping Sun

Professor of Biology

Office: 
3104 French Family Science Center, Durham, NC 27708
Campus Box: 
Box 90338, Durham, NC 27708-0338
Phone: 
(919) 613-8166
The diterpenoid phytohormone gibberellin (GA) plays pivotal roles in regulating growth and development throughout the life cycle of higher plants.  Mutations affecting GA biosynthesis or GA response were the key to control plant stature in wheat and rice that led to dramatically increased grain yield and contributed greatly to the success of the ‘Green Revolution’ in the 1960s.  By multi-faceted approaches using the reference plant Arabidopsis, my lab has made major breakthroughs in elucidating the sites and regulatory mechanisms of GA biosynthesis, and the conserved molecular events of GA perception and the early GA signaling pathway.  We identified the nuclear transcriptional regulators DELLA proteins, which function as master growth repressors by inhibiting all aspects of GA responses.  Binding of GA to its nuclear receptor GID1 enhances the GID1-DELLA interaction, which in turn leads to the rapid proteolysis of DELLA through the ubiquitin-proteasome pathway, and allows transcriptional reprogramming of GA-responsive genes.  We and other researchers further showed that GA-GID1-DELLA is a key regulatory module that controls plant growth by integrating internal developmental cues, and external biotic and abiotic signals (light, cold, salt and pathogen stresses).  DELLA proteins play a central role in these processes via direct protein-protein interactions with key transcription factors.  Our recent studies using genetic and physiological analyses together with chemical biology methods indicate that DELLA’s binding affinity to interacting proteins are oppositely regulated by two novel O-linked glycosylations on specific Ser/Thr residues: O-linked N-acetylglucosamine (O-GlcNAc) modification reduces DELLA activity, whereas O-fucosylation enhances DELLA activity.  We are investigating the global functions of O-GlcNAcylation and O-fucosylation in regulating plant development.

Education

  • Ph.D., Duke University 1987

  • B.S., National Tsing Hua University (Taiwan) 1980

Sun, T. P. “Gibberellin signal transduction in stem elongation & leaf growth.” In Plant Hormones: Biosynthesis, Signal Transduction, Action!, 308–28, 2010. https://doi.org/10.1007/978-1-4020-2686-7_15. Full Text

Crawford, B. M., H. N. Wang, P. Strobbia, R. Zentella, Z. M. Pei, T. P. Sun, and T. Vo-Dinh. “Plasmonic Nanobiosensing: From in situ plant monitoring to cancer diagnostics at the point of care.” Jphys Photonics 2, no. 3 (July 7, 2020). https://doi.org/10.1088/2515-7647/ab9714. Full Text

Wang, Yan, Yuqing He, Chen Su, Rodolfo Zentella, Tai-Ping Sun, and Lei Wang. “Nuclear Localized O-Fucosyltransferase SPY Facilitates PRR5 Proteolysis to Fine-Tune the Pace of Arabidopsis Circadian Clock.Molecular Plant 13, no. 3 (March 2020): 446–58. https://doi.org/10.1016/j.molp.2019.12.013. Full Text

Yang, Emily J., Chan Yul Yoo, Jiangxin Liu, He Wang, Jun Cao, Fay-Wei Li, Kathleen M. Pryer, et al. “NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches.Nat Commun 10, no. 1 (June 14, 2019): 2630. https://doi.org/10.1038/s41467-019-10517-1. Full Text Open Access Copy

Strobbia, Pietro, Yang Ran, Bridget M. Crawford, Vanessa Cupil-Garcia, Rodolfo Zentella, Hsin-Neng Wang, Tai-Ping Sun, and Tuan Vo-Dinh. “Inverse Molecular Sentinel-Integrated Fiberoptic Sensor for Direct and in Situ Detection of miRNA Targets.Analytical Chemistry 91, no. 9 (May 2019): 6345–52. https://doi.org/10.1021/acs.analchem.9b01350. Full Text

Crawford, Bridget M., Pietro Strobbia, Hsin-Neng Wang, Rodolfo Zentella, Maxim I. Boyanov, Zhen-Ming Pei, Tai-Ping Sun, Kenneth M. Kemner, and Tuan Vo-Dinh. “Plasmonic Nanoprobes for in Vivo Multimodal Sensing and Bioimaging of MicroRNA within Plants.Acs Applied Materials & Interfaces 11, no. 8 (February 12, 2019): 7743–54. https://doi.org/10.1021/acsami.8b19977. Full Text

Yang, E. J., C. Y. Yoo, J. Liu, H. Wang, J. Cao, F. Li, K. M. Pryer, T. Sun, D. Weigel, and P. Zhou. “NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches.” Nature Communications 10, no. 1 (2019): 1–13. Open Access Copy

Shinozaki, Yoshihito, Kentaro Ezura, Jianhong Hu, Yoshihiro Okabe, Camille Bénard, Duyen Prodhomme, Yves Gibon, Tai-Ping Sun, Hiroshi Ezura, and Tohru Ariizumi. “Identification and functional study of a mild allele of SlDELLA gene conferring the potential for improved yield in tomato.Scientific Reports 8, no. 1 (August 13, 2018): 12043. https://doi.org/10.1038/s41598-018-30502-w. Full Text

Zentella, Rodolfo, Ning Sui, Benjamin Barnhill, Wen-Ping Hsieh, Jianhong Hu, Jeffrey Shabanowitz, Michael Boyce, et al. “The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA.Nat Chem Biol 13, no. 5 (May 2017): 479–85. https://doi.org/10.1038/nchembio.2320. Full Text Open Access Copy

Pages

Cupil-Garcia, V., P. Strobbia, B. M. Crawford, H. N. Wang, R. Zentella, T. P. Sun, and T. Vo-Dinh. “Applications of plasmonic nanoparticles for in vivo biosensing of plants.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 11257, 2020. https://doi.org/10.1117/12.2553020. Full Text

Cupil-Garcia, V., P. Strobbia, Y. Ran, B. M. Crawford, H. N. Wang, R. Zentella, T. P. Sun, and T. Vo-Dinh. “Fiberoptics SERS sensors using plasmonic nanostar probes for detection of molecular biotargets.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 11257, 2020. https://doi.org/10.1117/12.2552993. Full Text

Strobbia, P., B. M. Crawford, H. N. Wang, R. Zentella, M. I. Boyanov, Z. M. Pei, T. P. Sun, K. M. Kemner, and T. Vo-Dinh. “Application of plasmonic nanoprobes for SERS sensing and imaging of biotargets in plant systems.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 10894, 2019. https://doi.org/10.1117/12.2512010. Full Text

Crawford, B. M., P. Strobbia, H. N. Wang, R. Zentella, M. I. Boyanov, R. Odion, Z. M. Pei, T. P. Sun, K. M. Kemner, and T. Vo-Dinh. “In vivo nucleic acid detection and imaging within whole plants using plasmonic nanosensors.” In Proceedings of Spie  the International Society for Optical Engineering, Vol. 11007, 2019. https://doi.org/10.1117/12.2524840. Full Text

Crawford, B. M., P. Strobbia, H. N. Wang, R. Zentella, M. I. Boyanov, Z. M. Pei, T. P. Sun, K. M. Kemner, and T. Vo-Dinh. “In vivo detection of microRNA within plants using plasmonic nanosensors.” In Proceedings of Spie  the International Society for Optical Engineering, Vol. 11082, 2019. https://doi.org/10.1117/12.2529818. Full Text

Strobbia, P., Y. Ran, B. M. Crawford, V. Cupil-Garcia, R. Zentella, H. N. Wang, T. P. Sun, and T. Vo-Dinh. “Inverse molecular sentinel-integrated fiber sensor for direct detection of miRNA targets.” In Proceedings of Spie  the International Society for Optical Engineering, Vol. 11082, 2019. https://doi.org/10.1117/12.2529844. Full Text

Selected Grants

Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025

Molecular Mechanism of Master Growth Repressor DELLA Signaling in Arabidopsis awarded by National Science Foundation (Principal Investigator). 2018 to 2022

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Plasmonics-Enhanced Optical Imaging Systems for Bioenergy Research awarded by Department of Energy (Co Investigator). 2018 to 2021

Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020

Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020

Multi-functional Plasmonics Nanoprobes for Cellular Sensing and Imaging awarded by Department of Energy (Co Investigator). 2015 to 2019

Acquisition of a MALDI-TOF Mass Spectrometer System at Duke University awarded by North Carolina Biotechnology Center (Major User). 2017 to 2018

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