Steven B. Haase

Associate Professor of Biology

Office: 
4316 French, Durham, NC 27708
Campus Box: 
Box 90338, Durham, NC 27708-1000
Phone: 
(919) 613-8205
Our group is broadly interested in understanding the biological clock mechanisms that control the timing of events during the cell division cycle. In 2008, the Haase group proposed a new model in which a complex network of sequentially activated transcription factors regulates the precise timing of gene expression during the cell-cycle, and functions as a robust time-keeping oscillator. Greater than a thousand genes are expressed at distinct phases of the cycle, and the control network itself consists of ~20 components, so this dynamical system is far too complex to understand simply by biological intuition. We rely heavily on the expertise of the Harer group (Dept. of Mathematics, Duke University) for the analysis of complex data, and their understanding of dynamical systems.  Using a collection of tools, including molecular genetics, genomics, mathematical models, and statistical inference, our groups aim to understand how the cell division clock works, how it might be perturbed in proliferative diseases such as cancer, and how the clock components might be targeted for new anti-tumor therapies.  Qualitatively, the clock networks that control the yeast cell cycle look much like the networks controlling circadian rhythms in a variety of organisms. More recently, we have been using our experimental and quantitative approaches to investigate the function of circadian clocks, as well as clocks that control the division and development of pathogenic organisms such as P. falciparum and P. vivax, the causative agents of malaria.

Education

  • Ph.D., Stanford University 1993

  • B.S., Colorado State University 1985

Smith, Lauren M., Francis C. Motta, Garima Chopra, J Kathleen Moch, Robert R. Nerem, Bree Cummins, Kimberly E. Roche, et al. “An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum.Science (New York, N.Y.) 368, no. 6492 (May 2020): 754–59. https://doi.org/10.1126/science.aba4357. Full Text

Cho, Chun-Yi, Christina M. Kelliher, and Steven B. Haase. “The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle.Cell Cycle (Georgetown, Tex.) 18, no. 4 (February 5, 2019): 363–78. https://doi.org/10.1080/15384101.2019.1570655. Full Text

Kelliher, Christina M., Matthew W. Foster, Francis C. Motta, Anastasia Deckard, Erik J. Soderblom, M Arthur Moseley, and Steven B. Haase. “Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae.Mol Biol Cell 29, no. 22 (November 1, 2018): 2644–55. https://doi.org/10.1091/mbc.E18-04-0255. Full Text

Moseley, Robert C., Ritesh Mewalal, Francis Motta, Gerald A. Tuskan, Steve Haase, and Xiaohan Yang. “Conservation and Diversification of Circadian Rhythmicity Between a Model Crassulacean Acid Metabolism Plant Kalanchoë fedtschenkoi and a Model C3 Photosynthesis Plant Arabidopsis thaliana.Frontiers in Plant Science 9 (January 2018): 1757. https://doi.org/10.3389/fpls.2018.01757. Full Text

Kelliher, Christina M., and Steven B. Haase. “Connecting virulence pathways to cell-cycle progression in the fungal pathogen Cryptococcus neoformans.Current Genetics 63, no. 5 (October 2017): 803–11. https://doi.org/10.1007/s00294-017-0688-5. Full Text

Cho, Chun-Yi, Francis C. Motta, Christina M. Kelliher, Anastasia Deckard, and Steven B. Haase. “Reconciling conflicting models for global control of cell-cycle transcription.Cell Cycle (Georgetown, Tex.) 16, no. 20 (October 2017): 1965–78. https://doi.org/10.1080/15384101.2017.1367073. Full Text

Kelliher, Christina M., Adam R. Leman, Crystal S. Sierra, and Steven B. Haase. “Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans.Plos Genetics 12, no. 12 (December 5, 2016): e1006453. https://doi.org/10.1371/journal.pgen.1006453. Full Text

McGoff, Kevin A., Xin Guo, Anastasia Deckard, Christina M. Kelliher, Adam R. Leman, Lauren J. Francey, John B. Hogenesch, Steven B. Haase, and John L. Harer. “The Local Edge Machine: inference of dynamic models of gene regulation.Genome Biology 17, no. 1 (October 19, 2016): 214. https://doi.org/10.1186/s13059-016-1076-z. Full Text

Perea, Jose A., Anastasia Deckard, Steve B. Haase, and John Harer. “SW1PerS: Sliding windows and 1-persistence scoring; discovering periodicity in gene expression time series data.Bmc Bioinformatics 16 (August 16, 2015): 257. https://doi.org/10.1186/s12859-015-0645-6. Full Text

Bristow, Sara L., Adam R. Leman, Laura A. Simmons Kovacs, Anastasia Deckard, John Harer, and Steven B. Haase. “Checkpoints couple transcription network oscillator dynamics to cell-cycle progression.Genome Biology 15, no. 9 (September 5, 2014): 446. https://doi.org/10.1186/s13059-014-0446-7. Full Text

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Selected Grants

Genetic and Genomics Training Grant awarded by National Institutes of Health (Principal Investigator). 2020 to 2025

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Needle in a Haystack: Effective Search for Dynamics in the Space of Networks awarded by (Principal Investigator). 2017 to 2022

Tripods+X:Res:Collaborative Research: Identification of Gene Regulatory Network Function from Data awarded by National Science Foundation (Principal Investigator). 2018 to 2021

Molecular Mycology and Pathogenesis Training Program awarded by National Institutes of Health (Mentor). 2019 to 2021

Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021

An Adaptive Pipeline from Scientific Data to Models awarded by Defense Advanced Research Projects Agency (Principal Investigator). 2017 to 2020

Genetics Training Grant awarded by National Institutes of Health (Principal Investigator). 1979 to 2020

Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020

Impact of Sickle-Trait on Transcriptional Regulation in P. Falciparum Parasites awarded by National Institutes of Health (Co Investigator). 2017 to 2020

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