L. Ryan Baugh

Associate Professor of Biology

4314 French Family Science Center, Duke Box 90338, Durham, NC 27708
Campus Box: 
Duke Box 90338, Durham, NC 27708-4129
(919) 613-8179
We study nutritional control of development in the roundworm Caenorhabditis elegans. We are interested in the signaling pathways and gene regulatory mechanisms that enable the worm to reversibly arrest development and resist stress in response to starvation. We are also interested in epigenetic mechanisms that mediate transgenerational effects of starvation.


  • Ph.D., Harvard University 2004

  • B.S., University of Georgia at Athens 1997

Kaplan, REW, Maxwell, CS, Codd, NK, and Baugh, LR. "Pervasive Positive and Negative Feedback Regulation of Insulin-Like Signaling in Caenorhabditis elegans." Genetics 211, no. 1 (January 2019): 349-361. Full Text

Burton, NO, Dwivedi, VK, Burkhart, KB, Kaplan, REW, Baugh, LR, and Horvitz, HR. "Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response." Nature Communications 9, no. 1 (December 4, 2018): 5152-null. Full Text

Hibshman, JD, Leuthner, TC, Shoben, C, Mello, DF, Sherwood, DR, Meyer, JN, and Baugh, LR. "Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans." American Journal of Physiology. Cell Physiology 315, no. 6 (December 2018): C781-C792. Full Text

Kaplan, REW, Webster, AK, Chitrakar, R, Dent, JA, and Baugh, LR. "Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans." Bmc Biology 16, no. 1 (October 8, 2018): 112-null. Full Text

Jordan, JM, Hibshman, JD, Kaplan, REW, Webster, AK, Leinroth, A, Maxwell, CS, Bowman, EA, Hubbard, EJA, and Baugh, LR. "Intergenerational Effects of Dietary Restriction and Insulin/IGF Signaling on Starvation Resistance and Reproductive Development." (October 2, 2018). Open Access Copy

Webster, AK, Jordan, JM, Hibshman, JD, Chitrakar, R, and Baugh, LR. "Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in Caenorhabditis elegans." Genetics 210, no. 1 (September 2018): 263-274. Full Text

Hibshman, JD, Hung, A, and Baugh, LR. "Correction: Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance." Plos Genetics 14, no. 8 (August 30, 2018): e1007639-null. Full Text

Webster, A, Jordan, J, Hibshman, J, Chitrakar, R, and Baugh, R. "Dauer diapause has transgenerational effects on starvation survival and gene expression plasticity." (June 8, 2018). Full Text


Roehrig, CJ, Baugh, LR, Claggett, JM, Shen-Orr, S, Smith, JJ, Yanai, I, and Hunter, P. "Caution, regulatory network assembly in progress.": Elsevier BV, July 2006. Full Text

Baugh, LR, Hill-Harfe, K, Hill, AA, Wen, JC, Slonim, DK, Brown, EL, and Hunter, CP. "Characterization of the C-elegans embryonic regulatory network specified by PAL-1." July 15, 2003.

Selected Grants

Discovery of conserved molecular mechanisms underlying population-wide variation in toxin responses awarded by Northwestern University (Principal Investigator). 2019 to 2024

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021

Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020

Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020

Systemic, maternal and transgenerational effects of nutrient stress awarded by National Institutes of Health (Principal Investigator). 2015 to 2019

Dissection on an Insulin-Like Signaling Network Controlling C. elegans Development awarded by National Science Foundation (Principal Investigator). 2011 to 2017

Genome-wide quantitative genetic analysis of growth and starvation survival awarded by National Institutes of Health (Principal Investigator). 2014 to 2017

COPAS BIOSORT Worm Sorter awarded by National Institutes of Health (Collaborator). 2009 to 2010