L. Ryan Baugh

Associate Professor of Biology

Office: 
4314 French Family Science Center, Duke Box 90338, Durham, NC 27708
Campus Box: 
Duke Box 90338, Durham, NC 27708-4129
Phone: 
(919) 613-8179
Email: 
ryan.baugh@duke.edu
We study nutritional control of development in the roundworm Caenorhabditis elegans. We are interested in the signaling pathways and gene regulatory mechanisms that enable the worm to reversibly arrest development and resist stress in response to starvation. We are also interested in epigenetic mechanisms that mediate transgenerational effects of starvation.

Education

  • Ph.D., Harvard University 2004

  • B.S., University of Georgia at Athens 1997

Burton, NO, Furuta, T, Webster, AK, Kaplan, REW, Baugh, LR, Arur, S, and Horvitz, HR. "Insulin-like signalling to the maternal germline controls progeny response to osmotic stress." Nature cell biology 19, no. 3 (March 2017): 252-257. Full Text

Hibshman, JD, Hung, A, and Baugh, LR. "Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance." PLoS Genetics 12, no. 10 (October 26, 2016): e1006396-. Full Text Open Access Copy

Kaplan, REW, and Baugh, LR. "L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development." Worm 5, no. 2 (April 6, 2016): e1175196-. Full Text Open Access Copy

Kaplan, REW, Chen, Y, Moore, BT, Jordan, JM, Maxwell, CS, Schindler, AJ, and Baugh, LR. "dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest." PLoS genetics 11, no. 12 (December 11, 2015): e1005731-. Full Text Open Access Copy

Jobson, MA, Jordan, JM, Sandrof, MA, Hibshman, JD, Lennox, AL, and Baugh, LR. "Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans." Genetics 201, no. 1 (September 2015): 201-212. Full Text Open Access Copy

Schindler, AJ, Baugh, LR, and Sherwood, DR. "Identification of late larval stage developmental checkpoints in Caenorhabditis elegans regulated by insulin/IGF and steroid hormone signaling pathways." PLoS genetics 10, no. 6 (June 19, 2014): e1004426-. Full Text Open Access Copy

Maxwell, CS, Kruesi, WS, Core, LJ, Kurhanewicz, N, Waters, CT, Lewarch, CL, Antoshechkin, I, Lis, JT, Meyer, BJ, and Baugh, LR. "Pol II docking and pausing at growth and stress genes in C. elegans." Cell reports 6, no. 3 (February 2014): 455-466. Full Text Open Access Copy

Chen, Y, and Baugh, LR. "Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest." Developmental Biology 394, no. 2 (January 1, 2014): 314-326. Full Text Open Access Copy

Baugh, LR. "To grow or not to grow: nutritional control of development during Caenorhabditis elegans L1 arrest." Genetics 194, no. 3 (July 2013): 539-555. (Review) Full Text Open Access Copy

Moore, BT, Jordan, JM, and Baugh, LR. "WormSizer: high-throughput analysis of nematode size and shape." PLoS One 8, no. 2 (2013): e57142-. Full Text Open Access Copy

Pages

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020

Dissection on an Insulin-Like Signaling Network Controlling C. elegans Development awarded by National Science Foundation (Principal Investigator). 2011 to 2017

Genome-wide quantitative genetic analysis of growth and starvation survival awarded by National Institutes of Health (Principal Investigator). 2014 to 2017

COPAS BIOSORT Worm Sorter awarded by National Institutes of Health (Collaborator). 2009 to 2010

Due to sponsor publicity restrictions, some awards may not be displayed.