L. Ryan Baugh

Associate Professor of Biology

4314 French Family Science Center, Duke Box 90338, Durham, NC 27708
Campus Box: 
Duke Box 90338, Durham, NC 27708-4129
(919) 613-8179
We use the roundworm Caenorhabditis elegans as model to investigate how animals cope with fluctuations in food availability. We are interested in the signaling pathways and gene regulatory mechanisms that enable this worm to reversibly arrest development and endure starvation. We are interested in adaptation to nutrient stress over different time scalse, including nongenetic inheritance and multigenerational phenotypic plasticity.


  • Ph.D., Harvard University 2004

  • B.S., University of Georgia, Athens 1997

Noble, Luke M., John Yuen, Lewis Stevens, Nicolas Moya, Riaad Persaud, Marc Moscatelli, Jacqueline L. Jackson, et al. “Selfing is the safest sex for Caenorhabditis tropicalis.Elife 10 (January 11, 2021). https://doi.org/10.7554/elife.62587. Full Text

Baugh, L Ryan, and Patrick J. Hu. “Starvation Responses Throughout the Caenorhabditis elegans Life Cycle.Genetics 216, no. 4 (December 2020): 837–78. https://doi.org/10.1534/genetics.120.303565. Full Text

Webster, Amy K., Anthony Hung, Brad T. Moore, Ryan Guzman, James M. Jordan, Rebecca E. W. Kaplan, Jonathan D. Hibshman, et al. “Population Selection and Sequencing of Caenorhabditis elegans Wild Isolates Identifies a Region on Chromosome III Affecting Starvation Resistance.G3 (Bethesda, Md.) 9, no. 10 (October 7, 2019): 3477–88. https://doi.org/10.1534/g3.119.400617. Full Text

Jordan, James M., Jonathan D. Hibshman, Amy K. Webster, Rebecca E. W. Kaplan, Abigail Leinroth, Ryan Guzman, Colin S. Maxwell, et al. “Insulin/IGF Signaling and Vitellogenin Provisioning Mediate Intergenerational Adaptation to Nutrient Stress.Current Biology : Cb 29, no. 14 (July 4, 2019): 2380-2388.e5. https://doi.org/10.1016/j.cub.2019.05.062. Full Text

Kaplan, Rebecca E. W., Colin S. Maxwell, Nicole Kurhanewicz Codd, and L Ryan Baugh. “Pervasive Positive and Negative Feedback Regulation of Insulin-Like Signaling in Caenorhabditis elegans.Genetics 211, no. 1 (January 2019): 349–61. https://doi.org/10.1534/genetics.118.301702. Full Text

Burton, Nicholas O., Vivek K. Dwivedi, Kirk B. Burkhart, Rebecca E. W. Kaplan, L Ryan Baugh, and H Robert Horvitz. “Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.Nature Communications 9, no. 1 (December 4, 2018): 5152. https://doi.org/10.1038/s41467-018-07640-w. Full Text

Hibshman, Jonathan D., Tess C. Leuthner, Chelsea Shoben, Danielle F. Mello, David R. Sherwood, Joel N. Meyer, and L Ryan Baugh. “Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans.American Journal of Physiology. Cell Physiology 315, no. 6 (December 2018): C781–92. https://doi.org/10.1152/ajpcell.00109.2018. Full Text

Kaplan, Rebecca E. W., Amy K. Webster, Rojin Chitrakar, Joseph A. Dent, and L Ryan Baugh. “Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans.Bmc Biology 16, no. 1 (October 8, 2018): 112. https://doi.org/10.1186/s12915-018-0579-3. Full Text


Schindler, A. J., L. R. Baugh, and D. R. Sherwood. “Identification of two novel insulin- and hormone-regulated nutritional checkpoints in C. elegans development.” In Integrative and Comparative Biology, 54:E185–E185. OXFORD UNIV PRESS INC, 2014.

Roehrig, Casey J., L Ryan Baugh, Julia M. Claggett, Shai Shen-Orr, Jessica J. Smith, Itai Yanai, and P. Hunter. “Caution, regulatory network assembly in progress.” In Developmental Biology, 295:450–450. Elsevier BV, 2006. https://doi.org/10.1016/j.ydbio.2006.04.387. Full Text

Baugh, L. R., K. Hill-Harfe, A. A. Hill, J. C. Wen, D. K. Slonim, E. L. Brown, and C. P. Hunter. “Characterization of the C-elegans embryonic regulatory network specified by PAL-1.” In Developmental Biology, 259:527–28. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2003.

Selected Grants

Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025

Systemic, maternal and transgenerational effects of nutrient stress awarded by National Institutes of Health (Principal Investigator). 2015 to 2023

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021

Discovery of conserved molecular mechanisms underlying population-wide variation in toxin responses awarded by Northwestern University (Principal Investigator). 2019 to 2021

Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020

Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020

Dissection on an Insulin-Like Signaling Network Controlling C. elegans Development awarded by National Science Foundation (Principal Investigator). 2011 to 2017

Genome-wide quantitative genetic analysis of growth and starvation survival awarded by National Institutes of Health (Principal Investigator). 2014 to 2017