L. Ryan Baugh
Associate Professor of Biology
Education
Ph.D., Harvard University 2004
B.S., University of Georgia, Athens 1997
Baugh, L Ryan, and Troy Day. “Nongenetic inheritance and multigenerational plasticity in the nematode C. elegans.” Elife 9 (August 25, 2020). https://doi.org/10.7554/elife.58498. Full Text
Webster, Amy K., Anthony Hung, Brad T. Moore, Ryan Guzman, James M. Jordan, Rebecca E. W. Kaplan, Jonathan D. Hibshman, et al. “Population Selection and Sequencing of Caenorhabditis elegans Wild Isolates Identifies a Region on Chromosome III Affecting Starvation Resistance.” G3 (Bethesda, Md.) 9, no. 10 (October 7, 2019): 3477–88. https://doi.org/10.1534/g3.119.400617. Full Text
Jordan, James M., Jonathan D. Hibshman, Amy K. Webster, Rebecca E. W. Kaplan, Abigail Leinroth, Ryan Guzman, Colin S. Maxwell, et al. “Insulin/IGF Signaling and Vitellogenin Provisioning Mediate Intergenerational Adaptation to Nutrient Stress.” Current Biology : Cb 29, no. 14 (July 4, 2019): 2380-2388.e5. https://doi.org/10.1016/j.cub.2019.05.062. Full Text
Kaplan, Rebecca E. W., Colin S. Maxwell, Nicole Kurhanewicz Codd, and L Ryan Baugh. “Pervasive Positive and Negative Feedback Regulation of Insulin-Like Signaling in Caenorhabditis elegans.” Genetics 211, no. 1 (January 2019): 349–61. https://doi.org/10.1534/genetics.118.301702. Full Text
Burton, Nicholas O., Vivek K. Dwivedi, Kirk B. Burkhart, Rebecca E. W. Kaplan, L Ryan Baugh, and H Robert Horvitz. “Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.” Nature Communications 9, no. 1 (December 4, 2018): 5152. https://doi.org/10.1038/s41467-018-07640-w. Full Text
Hibshman, Jonathan D., Tess C. Leuthner, Chelsea Shoben, Danielle F. Mello, David R. Sherwood, Joel N. Meyer, and L Ryan Baugh. “Nonselective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans.” American Journal of Physiology. Cell Physiology 315, no. 6 (December 2018): C781–92. https://doi.org/10.1152/ajpcell.00109.2018. Full Text
Kaplan, Rebecca E. W., Amy K. Webster, Rojin Chitrakar, Joseph A. Dent, and L Ryan Baugh. “Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans.” Bmc Biology 16, no. 1 (October 8, 2018): 112. https://doi.org/10.1186/s12915-018-0579-3. Full Text
Jordan, James M., Jonathan D. Hibshman, Rebecca E. W. Kaplan, Amy K. Webster, Abigail Leinroth, Colin S. Maxwell, Elizabeth Anne Bowman, E Jane Albert Hubbard, and L Ryan Baugh. “Intergenerational Effects of Dietary Restriction and Insulin/IGF Signaling on Starvation Resistance and Reproductive Development,” October 2, 2018. Open Access Copy
Webster, Amy K., James M. Jordan, Jonathan D. Hibshman, Rojin Chitrakar, and L Ryan Baugh. “Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in Caenorhabditis elegans.” Genetics 210, no. 1 (September 2018): 263–74. https://doi.org/10.1534/genetics.118.301250. Full Text
Hibshman, Jonathan D., Anthony Hung, and L Ryan Baugh. “Correction: Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance.” Plos Genetics 14, no. 8 (August 30, 2018): e1007639. https://doi.org/10.1371/journal.pgen.1007639. Full Text
Pages
Schindler, A. J., L. R. Baugh, and D. R. Sherwood. “Identification of two novel insulin- and hormone-regulated nutritional checkpoints in C. elegans development.” In Integrative and Comparative Biology, 54:E185–E185. OXFORD UNIV PRESS INC, 2014.
Roehrig, Casey J., L Ryan Baugh, Julia M. Claggett, Shai Shen-Orr, Jessica J. Smith, Itai Yanai, and P. Hunter. “Caution, regulatory network assembly in progress.” In Developmental Biology, 295:450–450. Elsevier BV, 2006. https://doi.org/10.1016/j.ydbio.2006.04.387. Full Text
Baugh, L. R., K. Hill-Harfe, A. A. Hill, J. C. Wen, D. K. Slonim, E. L. Brown, and C. P. Hunter. “Characterization of the C-elegans embryonic regulatory network specified by PAL-1.” In Developmental Biology, 259:527–28. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2003.
Selected Grants
Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025
Systemic, maternal and transgenerational effects of nutrient stress awarded by National Institutes of Health (Principal Investigator). 2015 to 2023
Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes? awarded by National Institutes of Health (Co Investigator). 2017 to 2022
Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022
Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021
Discovery of conserved molecular mechanisms underlying population-wide variation in toxin responses awarded by Northwestern University (Principal Investigator). 2019 to 2021
Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020
Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020
Dissection on an Insulin-Like Signaling Network Controlling C. elegans Development awarded by National Science Foundation (Principal Investigator). 2011 to 2017
Genome-wide quantitative genetic analysis of growth and starvation survival awarded by National Institutes of Health (Principal Investigator). 2014 to 2017