L. Ryan Baugh

Associate Professor of Biology

Office:

4314 French Family Science Center, Duke Box 90338, Durham, NC 27708

Campus Box:

Duke Box 90338, Durham, NC 27708-4129

Phone:

(919) 613-8179

Email:

ryan.baugh@duke.edu

http://www.biology.duke.edu/baughlab

We study nutritional control of development in the roundworm Caenorhabditis elegans. We are interested in the signaling pathways and gene regulatory mechanisms that enable the worm to reversibly arrest development and resist stress in response to starvation. We are also interested in epigenetic mechanisms that mediate transgenerational effects of starvation.

Education

Ph.D., Harvard University 2004
B.S., University of Georgia at Athens 1997

Kaplan, REW, Maxwell, CS, Codd, NK, and Baugh, LR. "Pervasive Positive and Negative Feedback Regulation of Insulin-Like Signaling in Caenorhabditis elegans." Genetics (November 13, 2018). Full Text

Kaplan, REW, Webster, AK, Chitrakar, R, Dent, JA, and Baugh, LR. "Food perception without ingestion leads to metabolic changes and irreversible developmental arrest in C. elegans." Bmc Biology 16, no. 1 (October 8, 2018): 112-null. Full Text

Webster, AK, Jordan, JM, Hibshman, JD, Chitrakar, R, and Baugh, LR. "Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in Caenorhabditis elegans." Genetics 210, no. 1 (September 2018): 263-274. Full Text

Hibshman, JD, Hung, A, and Baugh, LR. "Correction: Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance." Plos Genetics 14, no. 8 (August 30, 2018): e1007639-null. Full Text

Webster, A, Jordan, J, Hibshman, J, Chitrakar, R, and Baugh, R. "Dauer diapause has transgenerational effects on starvation survival and gene expression plasticity." (June 8, 2018). Full Text

Maxwell, C, Kaplan, R, Codd, NK, and Baugh, R. "Pervasive positive and negative feedback regulation of insulin like signaling in Caenorhabditis elegans." (June 7, 2018). Full Text

Kaplan, R, Webster, A, Chitrakar, R, Dent, J, and Baugh, R. "Perception of environmental polypeptides in C. elegans activates insulin/IGF signaling and alters lipid metabolism." (June 7, 2018). Full Text

Burton, N, Dwivedi, V, Burkhart, K, Kaplan, R, Baugh, R, and Horvitz, R. "Neurohormonal signalling controls insulin sensitivity and specificity in C. elegans." (December 5, 2017). Full Text

Hibshman, JD, Doan, AE, Moore, BT, Kaplan, RE, Hung, A, Webster, AK, Bhatt, DP, Chitrakar, R, Hirschey, MD, and Baugh, LR. "daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival." eLife 6 (October 24, 2017). Full Text

Fradin, H, Kiontke, K, Zegar, C, Gutwein, M, Lucas, J, Kovtun, M, Corcoran, DL, Baugh, LR, Fitch, DHA, Piano, F, and Gunsalus, KC. "Genome Architecture and Evolution of a Unichromosomal Asexual Nematode." Current Biology : Cb 27, no. 19 (October 2017): 2928-2939.e6. Full Text

Pages

Schindler, AJ, Baugh, LR, and Sherwood, DR. "Identification of two novel insulin- and hormone-regulated nutritional checkpoints in C. elegans development." 2014.

Roehrig, CJ, Baugh, LR, Claggett, JM, Shen-Orr, S, Smith, JJ, Yanai, I, and Hunter, P. "Caution, regulatory network assembly in progress." July 2006. Full Text

Baugh, LR, Hill-Harfe, K, Hill, AA, Wen, JC, Slonim, DK, Brown, EL, and Hunter, CP. "Characterization of the C-elegans embryonic regulatory network specified by PAL-1." July 15, 2003.

New Scholar in Aging Award. Ellison Medical Foundation. 2010