Kenneth Daniel Poss

Professor of Biology

307 Research Drive, Nanaline Bldg Room 466 A, Durham, NC 27710
Campus Box: 
Duke Box 3709, Durham, NC 27710
(919) 681-8457
Modeling disease in zebrafish
Genetic approaches to organ regeneration
Cardiac regeneration
Appendage regeneration
Developmental biology


  • Postdoctoral Fellow, Cardiology, Children's Hospital 2000 - 2003

  • Research Fellow, University of Utah 1998 - 2000

  • Ph.D., Massachusetts Institute of Technology 1998

Poss, K. D., and B. Kühn. Preface. Vol. 2158, 2021.

Major, R. J., and K. D. Poss. “III. Does heart regeneration occur?: B. Zebrafish heart regeneration.” In Heart Regeneration: Stem Cells and Beyond, 59–80, 2012. Full Text

Poss, Kenneth D., and Elly M. Tanaka. “A new society for regenerative biologists.Development 148, no. 3 (February 12, 2021). Full Text

Ye, Lihua, Munhyung Bae, Chelsi D. Cassilly, Sairam V. Jabba, Daniel W. Thorpe, Alyce M. Martin, Hsiu-Yi Lu, et al. “Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.Cell Host Microbe 29, no. 2 (February 10, 2021): 179-196.e9. Full Text

De Simone, Alessandro, Maya N. Evanitsky, Luke Hayden, Ben D. Cox, Julia Wang, Valerie A. Tornini, Jianhong Ou, Anna Chao, Kenneth D. Poss, and Stefano Di Talia. “Control of osteoblast regeneration by a train of Erk activity waves.Nature 590, no. 7844 (February 2021): 129–33. Full Text

Mukherjee, Debanjan, Ganesh Wagh, Mayssa H. Mokalled, Zacharias Kontarakis, Amy L. Dickson, Amey Rayrikar, Stefan Günther, Kenneth D. Poss, Didier Y. R. Stainier, and Chinmoy Patra. “Ccn2a is an injury-induced matricellular factor that promotes cardiac regeneration in zebrafish.Development 148, no. 2 (January 18, 2021). Full Text

Sun, Fei, Adam R. Shoffner, and Kenneth D. Poss. “A Genetic Cardiomyocyte Ablation Model for the Study of Heart Regeneration in Zebrafish.Methods Mol Biol 2158 (2021): 71–80. Full Text

Chen, Anzhi, Yanchao Han, and Kenneth D. Poss. “Regulation of zebrafish fin regeneration by vitamin D signaling.Dev Dyn, October 16, 2020. Full Text

Ramkumar, Nitya, Fei Sun, and Kenneth D. Poss. “Tissue Repair: A Tendon-see to Regenerate.Curr Biol 30, no. 17 (September 7, 2020): R1001–3. Full Text

Shoffner, Adam, Valentina Cigliola, Nutishia Lee, Jianhong Ou, and Kenneth D. Poss. “Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration.Cell Rep 32, no. 9 (September 1, 2020): 108089. Full Text

Goldman, Joseph A., and Kenneth D. Poss. “Gene regulatory programmes of tissue regeneration.Nat Rev Genet 21, no. 9 (September 2020): 511–25. Full Text

Thompson, John D., Jianhong Ou, Nutishia Lee, Kwangdeok Shin, Valentina Cigliola, Lingyun Song, Gregory E. Crawford, Junsu Kang, and Kenneth D. Poss. “Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration.Development 147, no. 14 (July 30, 2020). Full Text


Merriman, A. F., C. Chen, and K. D. Poss. “Identification of new regeneration mutants in zebrafish by a forward genetic screen.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.

Waxman, Joshua S., Brian R. Keegan, Richard W. Roberts, Kenneth D. Poss, and Deborah Yelon. “Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish.” In Developmental Biology, 319:482–482. Elsevier BV, 2008. Full Text

Kikuchi, Kazu, and Kenneth D. Poss. “Cardiac progenitors during zebrafish heart regeneration.” In Circulation Research, 101:E57–E57. LIPPINCOTT WILLIAMS & WILKINS, 2007.

Lee, Y., S. Grill, M. Murphy-Ryan, and K. D. Poss. “A proximodistal gradient of Fgf signaling defines position-dependent rates of zebrafish fin regeneration.” In Developmental Biology, 283:642–642. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005.

Selected Grants

Leveraging zebrafish models to dissect and enhance heart regeneration awarded by National Institutes of Health (Principal Investigator). 2020 to 2027

Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025

Genetic approaches to skin regeneration in zebrafish awarded by National Institutes of Health (Mentor). 2020 to 2025

LIVE IMAGING OF BONE REGENERATION IN ZEBRAFISH awarded by National Institutes of Health (Co-Principal Investigator). 2020 to 2025

Advanced Immunobiology Traning Program for Surgeons awarded by National Institutes of Health (Mentor). 2019 to 2024

An integrative cellular blueprint of vertebrate tissue development awarded by University of California - San Diego (Co-Principal Investigator). 2018 to 2023

Dissecting the dynamics of vertebrate brain regeneration awarded by National Institutes of Health (Principal Investigator). 2020 to 2022

IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome awarded by National Science Foundation (Mentor). 2019 to 2022

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health (Mentor). 1975 to 2022