Kenneth Daniel Poss

Professor of Biology

307 Research Drive, Nanaline Bldg Room 466 A, Durham, NC 27710
Campus Box: 
Duke Box 3709, Durham, NC 27710
(919) 681-8457
Modeling disease in zebrafish
Genetic approaches to organ regeneration
Cardiac regeneration
Appendage regeneration
Developmental biology


  • Postdoctoral Fellow, Cardiology, Children's Hospital 2000 - 2003

  • Research Fellow, University of Utah 1998 - 2000

  • Ph.D., Massachusetts Institute of Technology 1998

Major, R. J., and K. D. Poss. “III. Does heart regeneration occur?: B. Zebrafish heart regeneration.” In Heart Regeneration: Stem Cells and Beyond, 59–80, 2012. Full Text

Honkoop, Hessel, Dennis Em de Bakker, Alla Aharonov, Fabian Kruse, Avraham Shakked, Phong D. Nguyen, Cecilia de Heus, et al. “Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.Elife 8 (December 23, 2019). Full Text

Wang, Ying-Ting, Tzu-Lun Tseng, Yu-Chia Kuo, Jr-Kai Yu, Yi-Hsien Su, Kenneth D. Poss, and Chen-Hui Chen. “Genetic Reprogramming of Positional Memory in a Regenerating Appendage.Curr Biol 29, no. 24 (December 16, 2019): 4193-4207.e4. Full Text

Marín-Juez, Rubén, Hadil El-Sammak, Christian S. M. Helker, Aosa Kamezaki, Sri Teja Mullapuli, Sofia-Iris Bibli, Matthew J. Foglia, Ingrid Fleming, Kenneth D. Poss, and Didier Y. R. Stainier. “Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.Dev Cell 51, no. 4 (November 18, 2019): 503-515.e4. Full Text

Gancz, Dana, Brian C. Raftrey, Gal Perlmoter, Rubén Marín-Juez, Jonathan Semo, Ryota L. Matsuoka, Ravi Karra, et al. “Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.Elife 8 (November 8, 2019). Full Text

Cox, Ben D., Maximina H. Yun, and Kenneth D. Poss. “Can laboratory model systems instruct human limb regeneration?Development 146, no. 20 (October 2, 2019). Full Text

Han, Yanchao, Anzhi Chen, Kfir-Baruch Umansky, Kelsey A. Oonk, Wen-Yee Choi, Amy L. Dickson, Jianhong Ou, et al. “Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish.Dev Cell 48, no. 6 (March 25, 2019): 853-863.e5. Full Text

Cox, Ben D., Alessandro De Simone, Valerie A. Tornini, Sumeet P. Singh, Stefano Di Talia, and Kenneth D. Poss. “In Toto Imaging of Dynamic Osteoblast Behaviors in Regenerating Skeletal Bone.Curr Biol 28, no. 24 (December 17, 2018): 3937-3947.e4. Full Text

Mokalled, Mayssa H., and Kenneth D. Poss. “A Regeneration Toolkit.Dev Cell 47, no. 3 (November 5, 2018): 267–80. Full Text

Walton, Eric M., Mark R. Cronan, C. J. Cambier, Andrea Rossi, Michele Marass, Matthew D. Foglia, W Jared Brewer, et al. “Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling.Cell Host Microbe 24, no. 4 (October 10, 2018): 514-525.e6. Full Text

Cao, Jingli, and Kenneth D. Poss. “The epicardium as a hub for heart regeneration.Nat Rev Cardiol 15, no. 10 (October 2018): 631–47. Full Text


Merriman, A. F., C. Chen, and K. D. Poss. “Identification of new regeneration mutants in zebrafish by a forward genetic screen.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.

Waxman, Joshua S., Brian R. Keegan, Richard W. Roberts, Kenneth D. Poss, and Deborah Yelon. “Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish.” In Developmental Biology, 319:482–482. Elsevier BV, 2008. Full Text

Kikuchi, Kazu, and Kenneth D. Poss. “Cardiac progenitors during zebrafish heart regeneration.” In Circulation Research, 101:E57–E57. LIPPINCOTT WILLIAMS & WILKINS, 2007.

Lee, Y., S. Grill, M. Murphy-Ryan, and K. D. Poss. “A proximodistal gradient of Fgf signaling defines position-dependent rates of zebrafish fin regeneration.” In Developmental Biology, 283:642–642. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005.

Selected Grants

LIVE IMAGING OF BONE REGENERATION IN ZEBRAFISH awarded by National Institutes of Health (Co-Principal Investigator). 2020 to 2025

Advanced Immunobiology Traning Program for Surgeons awarded by National Institutes of Health (Mentor). 2019 to 2024

Medical Scientist Training Program awarded by National Institutes of Health (Mentor). 1997 to 2022

IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome awarded by National Science Foundation (Mentor). 2019 to 2022

Regulation of Myocardial Regeneration in Zebrafish awarded by National Institutes of Health (Principal Investigator). 2005 to 2022

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health (Mentor). 1975 to 2021

Polyploidy in Cardiac Development and Tissue Repair in Drosophila awarded by National Institutes of Health (Co-Sponsor). 2018 to 2020

Eliciting heart regeneration through cardiomyocyte division awarded by (Principal Investigator). 2016 to 2020

Identification and application of regulatory elements for heart regeneration awarded by National Institutes of Health (Principal Investigator). 2016 to 2020