Kenneth Daniel Poss

Professor of Biology

307 Research Drive, Nanaline Bldg Room 466 A, Durham, NC 27710
Campus Box: 
Duke Box 3709, Durham, NC 27710
(919) 681-8457
Modeling disease in zebrafish
Genetic approaches to organ regeneration
Cardiac regeneration
Appendage regeneration
Developmental biology


  • Postdoctoral Fellow, Cardiology, Children's Hospital 2000 - 2003

  • Research Fellow, University of Utah 1998 - 2000

  • Ph.D., Massachusetts Institute of Technology 1998

Major, R. J., and K. D. Poss. “III. Does heart regeneration occur?: B. Zebrafish heart regeneration.” In Heart Regeneration: Stem Cells and Beyond, 59–80, 2012. Full Text

Goldman, Joseph A., and Kenneth D. Poss. “Gene regulatory programmes of tissue regeneration.Nat Rev Genet, June 5, 2020. Full Text

Cigliola, Valentina, Clayton J. Becker, and Kenneth D. Poss. “Building bridges, not walls: spinal cord regeneration in zebrafish.Dis Model Mech 13, no. 5 (May 27, 2020). Full Text

Pronobis, Mira I., and Kenneth D. Poss. “Signals for cardiomyocyte proliferation during zebrafish heart regeneration.Curr Opin Physiol 14 (April 2020): 78–85. Full Text

Wang, Zhaohui, Yang Li, Bing Hou, Mira I. Pronobis, Mingqiao Wang, Yuemeng Wang, Guangcun Cheng, et al. “An array of 60,000 antibodies for proteome-scale antibody generation and target discovery.Sci Adv 6, no. 11 (March 2020): eaax2271. Full Text

Honkoop, Hessel, Dennis Em de Bakker, Alla Aharonov, Fabian Kruse, Avraham Shakked, Phong D. Nguyen, Cecilia de Heus, et al. “Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.Elife 8 (December 23, 2019). Full Text

Wang, Ying-Ting, Tzu-Lun Tseng, Yu-Chia Kuo, Jr-Kai Yu, Yi-Hsien Su, Kenneth D. Poss, and Chen-Hui Chen. “Genetic Reprogramming of Positional Memory in a Regenerating Appendage.Curr Biol 29, no. 24 (December 16, 2019): 4193-4207.e4. Full Text

Marín-Juez, Rubén, Hadil El-Sammak, Christian S. M. Helker, Aosa Kamezaki, Sri Teja Mullapuli, Sofia-Iris Bibli, Matthew J. Foglia, Ingrid Fleming, Kenneth D. Poss, and Didier Y. R. Stainier. “Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.Dev Cell 51, no. 4 (November 18, 2019): 503-515.e4. Full Text

Gancz, Dana, Brian C. Raftrey, Gal Perlmoter, Rubén Marín-Juez, Jonathan Semo, Ryota L. Matsuoka, Ravi Karra, et al. “Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.Elife 8 (November 8, 2019). Full Text

Cox, Ben D., Maximina H. Yun, and Kenneth D. Poss. “Can laboratory model systems instruct human limb regeneration?Development 146, no. 20 (October 2, 2019). Full Text

Han, Yanchao, Anzhi Chen, Kfir-Baruch Umansky, Kelsey A. Oonk, Wen-Yee Choi, Amy L. Dickson, Jianhong Ou, et al. “Vitamin D Stimulates Cardiomyocyte Proliferation and Controls Organ Size and Regeneration in Zebrafish.Dev Cell 48, no. 6 (March 25, 2019): 853-863.e5. Full Text


Merriman, A. F., C. Chen, and K. D. Poss. “Identification of new regeneration mutants in zebrafish by a forward genetic screen.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.

Waxman, Joshua S., Brian R. Keegan, Richard W. Roberts, Kenneth D. Poss, and Deborah Yelon. “Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish.” In Developmental Biology, 319:482–482. Elsevier BV, 2008. Full Text

Kikuchi, Kazu, and Kenneth D. Poss. “Cardiac progenitors during zebrafish heart regeneration.” In Circulation Research, 101:E57–E57. LIPPINCOTT WILLIAMS & WILKINS, 2007.

Lee, Y., S. Grill, M. Murphy-Ryan, and K. D. Poss. “A proximodistal gradient of Fgf signaling defines position-dependent rates of zebrafish fin regeneration.” In Developmental Biology, 283:642–642. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005.

Selected Grants

Leveraging zebrafish models to dissect and enhance heart regeneration awarded by National Institutes of Health (Principal Investigator). 2020 to 2027

Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025

Genetic approaches to skin regeneration in zebrafish awarded by National Institutes of Health (Mentor). 2020 to 2025

LIVE IMAGING OF BONE REGENERATION IN ZEBRAFISH awarded by National Institutes of Health (Co-Principal Investigator). 2020 to 2025

Advanced Immunobiology Traning Program for Surgeons awarded by National Institutes of Health (Mentor). 2019 to 2024

Medical Scientist Training Program awarded by National Institutes of Health (Mentor). 1997 to 2022

IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome awarded by National Science Foundation (Mentor). 2019 to 2022

Regulation of Myocardial Regeneration in Zebrafish awarded by National Institutes of Health (Principal Investigator). 2005 to 2022

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health (Mentor). 1975 to 2021