Kenneth Daniel Poss

Professor of Biology

307 Research Drive, Nanaline Bldg Room 466 A, Durham, NC 27710
Campus Box: 
Duke Box 3709, Durham, NC 27710
(919) 681-8457
Modeling disease in zebrafish
Genetic approaches to organ regeneration
Cardiac regeneration
Appendage regeneration
Developmental biology


  • Postdoctoral Fellow, Cardiology, Children's Hospital 2000 - 2003

  • Research Fellow, University of Utah 1998 - 2000

  • Ph.D., Massachusetts Institute of Technology 1998

Poss, K. D., and B. Kühn. Preface. Vol. 2158, 2021.

Major, R. J., and K. D. Poss. “III. Does heart regeneration occur?: B. Zebrafish heart regeneration.” In Heart Regeneration: Stem Cells and Beyond, 59–80, 2012. Full Text

Sun, Fei, Adam R. Shoffner, and Kenneth D. Poss. “A Genetic Cardiomyocyte Ablation Model for the Study of Heart Regeneration in Zebrafish.Methods Mol Biol 2158 (2021): 71–80. Full Text

Ramkumar, Nitya, Fei Sun, and Kenneth D. Poss. “Tissue Repair: A Tendon-see to Regenerate.Curr Biol 30, no. 17 (September 7, 2020): R1001–3. Full Text

Goldman, Joseph A., and Kenneth D. Poss. “Gene regulatory programmes of tissue regeneration.Nat Rev Genet 21, no. 9 (September 2020): 511–25. Full Text

Shoffner, Adam, Valentina Cigliola, Nutishia Lee, Jianhong Ou, and Kenneth D. Poss. “Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration.Cell Rep 32, no. 9 (September 1, 2020): 108089. Full Text

Thompson, John D., Jianhong Ou, Nutishia Lee, Kwangdeok Shin, Valentina Cigliola, Lingyun Song, Gregory E. Crawford, Junsu Kang, and Kenneth D. Poss. “Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration.Development 147, no. 14 (July 30, 2020). Full Text

Cigliola, Valentina, Clayton J. Becker, and Kenneth D. Poss. “Building bridges, not walls: spinal cord regeneration in zebrafish.Dis Model Mech 13, no. 5 (May 27, 2020). Full Text

Pronobis, Mira I., and Kenneth D. Poss. “Signals for cardiomyocyte proliferation during zebrafish heart regeneration.Current Opinion in Physiology 14 (April 2020): 78–85. Full Text

Wang, Zhaohui, Yang Li, Bing Hou, Mira I. Pronobis, Mingqiao Wang, Yuemeng Wang, Guangcun Cheng, et al. “An array of 60,000 antibodies for proteome-scale antibody generation and target discovery.Sci Adv 6, no. 11 (March 2020): eaax2271. Full Text

Honkoop, Hessel, Dennis Em de Bakker, Alla Aharonov, Fabian Kruse, Avraham Shakked, Phong D. Nguyen, Cecilia de Heus, et al. “Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.Elife 8 (December 23, 2019). Full Text

Wang, Ying-Ting, Tzu-Lun Tseng, Yu-Chia Kuo, Jr-Kai Yu, Yi-Hsien Su, Kenneth D. Poss, and Chen-Hui Chen. “Genetic Reprogramming of Positional Memory in a Regenerating Appendage.Curr Biol 29, no. 24 (December 16, 2019): 4193-4207.e4. Full Text


Merriman, A. F., C. Chen, and K. D. Poss. “Identification of new regeneration mutants in zebrafish by a forward genetic screen.” In Molecular Biology of the Cell, Vol. 26. AMER SOC CELL BIOLOGY, 2015.

Waxman, Joshua S., Brian R. Keegan, Richard W. Roberts, Kenneth D. Poss, and Deborah Yelon. “Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish.” In Developmental Biology, 319:482–482. Elsevier BV, 2008. Full Text

Kikuchi, Kazu, and Kenneth D. Poss. “Cardiac progenitors during zebrafish heart regeneration.” In Circulation Research, 101:E57–E57. LIPPINCOTT WILLIAMS & WILKINS, 2007.

Lee, Y., S. Grill, M. Murphy-Ryan, and K. D. Poss. “A proximodistal gradient of Fgf signaling defines position-dependent rates of zebrafish fin regeneration.” In Developmental Biology, 283:642–642. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005.

Selected Grants

Leveraging zebrafish models to dissect and enhance heart regeneration awarded by National Institutes of Health (Principal Investigator). 2020 to 2027

Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025

Genetic approaches to skin regeneration in zebrafish awarded by National Institutes of Health (Mentor). 2020 to 2025

LIVE IMAGING OF BONE REGENERATION IN ZEBRAFISH awarded by National Institutes of Health (Co-Principal Investigator). 2020 to 2025

Advanced Immunobiology Traning Program for Surgeons awarded by National Institutes of Health (Mentor). 2019 to 2024

Dissecting the dynamics of vertebrate brain regeneration awarded by National Institutes of Health (Principal Investigator). 2020 to 2022

IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome awarded by National Science Foundation (Mentor). 2019 to 2022

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Eliciting heart regeneration through cardiomyocyte division awarded by Fondation Leducq (Principal Investigator). 2016 to 2021

Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health (Preceptor). 2009 to 2021