Gustavo M. Silva

Assistant Professor of Biology

Office: 
130 Science Drive, 3103 French, Durham, NC 27708
Campus Box: 
130 Science Drive, Box 90338, Durham, NC 27708
My main research goal is to understand and be able to control how cells respond to stressful and harmful conditions, which are the underlying causes of many human diseases. To achieve this goal, I study cellular response to stress at the protein level and aim to characterize the different regulatory functions mediated by the ubiquitin-proteasome system (UPS), essential machinery involved in modulating protein dynamics. Ultimately, regulating specific UPS roles will provide new tools to increase cellular tolerance to a variety of environmental stresses, which is highly relevant for a variety of degenerative diseases. The main focus of my lab is to investigate the unprecedented regulation of translation mediated by ubiquitin. I laid the groundwork for this research investigating the ubiquitination response in the budding yeast Saccharomyces cerevisiae and we will explore the evolutionary conservation of this pathway and its function in neuronal cells. Our lab is excited to keep pushing the field forward and to use a combination of proteomics, genomics, and molecular methods to understand the mechanisms by which ubiquitin regulates translation, and ultimately, cellular response to stress.

Education

  • Associate Research Scientist, Center For Genomics And Systems Biology, Department Of Biology, New York University 2011 - 2017

  • Ph.D., University of Sao Paulo (Brazil) 2010

  • Lic., University of Sao Paulo (Brazil) 2007

  • B.Sc., University of Sao Paulo (Brazil) 2004

Wiechecki, Keira, Sandhya Manohar, Gustavo Silva, Konstantine Tchourine, Samson Jacob, Angelo Valleriani, and Christine Vogel. “Integrative Meta-Analysis Reveals That Most Yeast Proteins Are Very Stable.” Ssrn Electronic Journal, n.d. https://doi.org/10.2139/ssrn.3155916. Full Text

Dougherty, Shannon E., Austin O. Maduka, Toshifumi Inada, and Gustavo M. Silva. “Expanding Role of Ubiquitin in Translational Control.” International Journal of Molecular Sciences 21, no. 3 (n.d.): 1151–1151. https://doi.org/10.3390/ijms21031151. Full Text

Pages

Fellowships, Supported Research, & Other Grants