Overview
We ask how the embryo works. Prior to morphogenesis the
embryo specifies each cell through transcriptional regulation
and signaling. Our research builds gene regulatory networks to
understand how that early specification works. We then ask how
this specification programs cells for their morphogenetic
movements at gastrulation, and how the cells deploy patterning
information.
Current projects examine 1) novel signal transduction
mechanisms that establish and maintain embryonic boundaries
mold the embryo at gastrulation; 2) specification of primary
mesenchyme cells in such a way that they are prepared to
execute an epithelial-mesenchymal transition, and then study
mechanistically the regulation of that transition; 3) the
specification of endoderm necessary for invagination of the
archenteron; 4) formation of the oral/aboral ectoderm and the
means by which patterning information is distributed three
dimensionally around the embryo. That information is necessary
for patterning and inducing skeletogenesis.
Other projects examine neural tube folding with the goal of
identifying genes associated with neural tube defects. Finally, a
large current effort in systems biology is being expended with
the goal of enlarging our knowledge of early networks and how
they interact.
Current Appointments & Affiliations
Arthur S. Pearse Distinguished Professor of Biology
·
2004 - Present
Biology,
Trinity College of Arts & Sciences
Professor Emeritus of Biology
·
2023 - Present
Biology,
Trinity College of Arts & Sciences
Professor of Neurobiology
·
2000 - Present
Neurobiology,
Basic Science Departments
Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Affiliate of the Duke Regeneration Center
·
2021 - Present
Regeneration Next Initiative,
Basic Science Departments
Education, Training & Certifications
University of North Carolina, Chapel Hill ·
1971
Ph.D.
University of Vermont ·
1965
M.S.
Pennsylvania State University ·
1963
B.S.