David R. McClay
Arthur S. Pearse Distinguished Professor of Biology
Education
Ph.D., University of North Carolina - Chapel Hill 1971
M.S., University of Vermont 1965
B.S., Pennsylvania State University 1963
McClay, David R., Jacob Warner, Megan Martik, Esther Miranda, and Leslie Slota. “Gastrulation in the sea urchin.,” 136:195–218, 2020. https://doi.org/10.1016/bs.ctdb.2019.08.004. Full Text
McClay, David. “Unlocking mechanisms of development through advances in tools.,” 151:37–41, 2019. https://doi.org/10.1016/bs.mcb.2019.03.005. Full Text
Massri, Abdull J., Geoffrey R. Schiebinger, Alejandro Berrio, Lingyu Wang, Gregory A. Wray, and David R. McClay. “Methodologies for Following EMT In Vivo at Single Cell Resolution.” Methods in Molecular Biology (Clifton, N.J.) 2179 (January 2021): 303–14. https://doi.org/10.1007/978-1-0716-0779-4_23. Full Text
McClay, David R. “Perspective on Epithelial-Mesenchymal Transitions in Embryos.” Methods in Molecular Biology (Clifton, N.J.) 2179 (January 2021): 7–12. https://doi.org/10.1007/978-1-0716-0779-4_2. Full Text
Massri, Abdull, Laura Greenstreet, Anton Afanassiev, Alejandro Berrio Escobar, Gregory Wray, Geoffrey Schiebinger, and David McClay. “Developmental Single-cell transcriptomics in the Lytechinus variegatus Sea Urchin Embryo,” November 13, 2020. https://doi.org/10.1101/2020.11.12.380675. Full Text Open Access Copy
Davidson, Phillip L., Haobing Guo, Lingyu Wang, Alejandro Berrio, He Zhang, Yue Chang, Andrew L. Soborowski, David R. McClay, Guangyi Fan, and Gregory A. Wray. “Chromosomal-Level Genome Assembly of the Sea Urchin Lytechinus variegatus Substantially Improves Functional Genomic Analyses.” Genome Biology and Evolution 12, no. 7 (July 2020): 1080–86. https://doi.org/10.1093/gbe/evaa101. Full Text
Yang, Jing, Parker Antin, Geert Berx, Cédric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, et al. “Guidelines and definitions for research on epithelial-mesenchymal transition.” Nature Reviews. Molecular Cell Biology 21, no. 6 (June 2020): 341–52. https://doi.org/10.1038/s41580-020-0237-9. Full Text
Slota, Leslie A., Esther Miranda, Brianna Peskin, and David R. McClay. “Developmental origin of peripheral ciliary band neurons in the sea urchin embryo.” Developmental Biology 459, no. 2 (March 2020): 72–78. https://doi.org/10.1016/j.ydbio.2019.12.011. Full Text
George, Andrew N., and David R. McClay. “Methods for transplantation of sea urchin blastomeres.” Methods in Cell Biology 150 (January 2019): 223–33. https://doi.org/10.1016/bs.mcb.2018.11.012. Full Text
Slota, Leslie A., Esther M. Miranda, and David R. McClay. “Spatial and temporal patterns of gene expression during neurogenesis in the sea urchin Lytechinus variegatus.” Evodevo 10 (January 2019): 2. https://doi.org/10.1186/s13227-019-0115-8. Full Text
McClay, David R., Esther Miranda, and Stacy L. Feinberg. “Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.” Development (Cambridge, England) 145, no. 21 (November 9, 2018). https://doi.org/10.1242/dev.167742. Full Text
Slota, Leslie A., and David R. McClay. “Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo.” Developmental Biology 435, no. 2 (March 2018): 138–49. https://doi.org/10.1016/j.ydbio.2017.12.015. Full Text
Pages
Lyons, Diedre, Dan McIntyre, and David R. McClay. “Ectodermal inputs into patterning skeletogenesis.” In Integrative and Comparative Biology, 54:E128–E128. OXFORD UNIV PRESS INC, 2014.
Lyons, Deirdre C., and David R. Mcclay. “Programmed cell fusion of PMCs during skeletal development in the sea urchin Lytechinus variegatus.” In Integrative and Comparative Biology, 52:E287–E287. OXFORD UNIV PRESS INC, 2012.
McIntyre, Daniel C., Winn Seay, and David R. McClay. “IrxA expression and function in establishing the sea urchin endoderm–ectoderm boundary.” In Developmental Biology, 344:469–469. Elsevier BV, 2010. https://doi.org/10.1016/j.ydbio.2010.05.226. Full Text
McClay, David R., Jenifer C. Croce, Shu-Yu Wu, Wendy S. Beane, and Katherine D. Walton. “Gene regulatory networks governing morphogenesis.” In Developmental Biology, 319:477–477. Elsevier BV, 2008. https://doi.org/10.1016/j.ydbio.2008.05.043. Full Text
Croce, Jenifer C., and David R. McClay. “A new role for an old gene: Brachyury and the subdivision of the endomesoderm.” In Developmental Biology, 306:294–294. Elsevier BV, 2007. https://doi.org/10.1016/j.ydbio.2007.03.065. Full Text
Beane, Wendy S., and David R. McClay. “Patterning the sea urchin skeleton: A role for calcium signaling.” In Developmental Biology, 306:400–400. Elsevier BV, 2007. https://doi.org/10.1016/j.ydbio.2007.03.599. Full Text
Wu, Shu-Yu, and David R. McClay. “Constructing the EMT regulatory network of PMCs in sea urchin embryos.” In Developmental Biology, 306:435–435. Elsevier BV, 2007. https://doi.org/10.1016/j.ydbio.2007.03.673. Full Text
Wu, Shu-Yu, and David R. McClay. “Epithelial–mesenchymal transition regulators Snail and Twist are required for PMC ingression in the sea urchin embryo.” In Developmental Biology, 295:411–411. Elsevier BV, 2006. https://doi.org/10.1016/j.ydbio.2006.04.263. Full Text
Beane, Wendy S., and David R. McClay. “Clearing the way: The small GTPase RhoA and endomesodermal specification.” In Developmental Biology, 295:411–12. Elsevier BV, 2006. https://doi.org/10.1016/j.ydbio.2006.04.264. Full Text
Bradham, Cynthia A., Albert J. Poustka, and David R. McClay. “Chordin is required for neural but not axial specification in sea urchin embryos.” In Developmental Biology, 295:331–331. Elsevier BV, 2006. https://doi.org/10.1016/j.ydbio.2006.04.035. Full Text
Selected Grants
Genetic and Genomics Training Grant awarded by National Institutes of Health (Mentor). 2020 to 2025
Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health (Principal Investigator). 1980 to 2023
Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022
Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021
How Gene Regulatory Networks Connect to Development awarded by California Institute of Technology (Principal Investigator). 2009 to 2021
Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020
Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020
Lightsheet Imaging System awarded by National Institutes of Health (Major User). 2016 to 2017
Illumina Hi-Seq 2000 Sequencing System awarded by National Institutes of Health (Major User). 2012 to 2013
Mechanism of a novel cause of spina bifida awarded by National Institutes of Health (Consultant). 2009 to 2012