David R. McClay

Arthur S. Pearse Professor of Biology in Trinity College of Arts and Sciences

Office: 
4102 French Science Center, Science Dr., Durham, NC 27708
Campus Box: 
90338
Phone: 
(919) 613-8188
Fax: 
(919) 660-7293

Research Interests: 

We ask how the embryo works. Prior to morphogenesis the embryo specifies each cell through transcriptional regulation and signaling. Our research builds gene regulatory networks to understand how that early specification works. We then ask how this specification programs cells for their morphogenetic movements at gastrulation, and how the cells deploy patterning information. Current projects examine 1) novel signal transduction mechanisms that establish and maintain embryonic boundaries mold the embryo at gastrulation; 2) specification of primary mesenchyme cells in such a way that they are prepared to execute an epithelial-mesenchymal transition, and then study mechanistically the regulation of that transition; 3) the specification of endoderm necessary for invagination of the archenteron; 4) formation of the oral/aboral ectoderm and the means by which patterning information is distributed three dimensionally around the embryo. That information is necessary for patterning and inducing skeletogenesis. Other projects examine neural tube folding with the goal of identifying genes associated with neural tube defects. Finally, a large current effort in systems biology is being expended with the goal of enlarging our knowledge of early networks and how they interact.

We ask how the embryo works. Prior to morphogenesis the
embryo specifies each cell through transcriptional regulation
and signaling. Our research builds gene regulatory networks to
understand how that early specification works. We then ask how
this specification programs cells for their morphogenetic
movements at gastrulation, and how the cells deploy patterning
information.
Current projects examine 1) novel signal transduction
mechanisms that establish and maintain embryonic boundaries
mold the embryo at gastrulation; 2) specification of primary
mesenchyme cells in such a way that they are prepared to
execute an epithelial-mesenchymal transition, and then study
mechanistically the regulation of that transition; 3) the
specification of endoderm necessary for invagination of the
archenteron; 4) formation of the oral/aboral ectoderm and the
means by which patterning information is distributed three
dimensionally around the embryo. That information is necessary
for patterning and inducing skeletogenesis.
Other projects examine neural tube folding with the goal of
identifying genes associated with neural tube defects. Finally, a
large current effort in systems biology is being expended with
the goal of enlarging our knowledge of early networks and how
they interact.

Education

  • Ph.D. 1971, University of North Carolina at Chapel Hill

  • M.S. 1965, University of Vermont

  • B.S. 1963, Pennsylvania State University

  • BS Zoology 1963, Penn State University

Papers Published

Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin., 3, 2016
Warner, JF; Miranda, EL; McClay, DR, Developmental Biology. 411 vol. (2); pp. 314-324

Comparative Developmental Transcriptomics Reveals Rewiring of a Highly Conserved Gene Regulatory Network during a Major Life History Switch in the Sea Urchin Genus Heliocidaris., 3, 2016
Israel, JW; Martik, ML; Byrne, M; Raff, EC; Raff, RA; McClay, DR; Wray, GA, PLoS biology. 14 vol. (3); pp. e1002391

Developmental gene regulatory networks in sea urchins and what we can learn from them., 1, 2016
Martik, ML; Lyons, DC; McClay, DR, F1000 Research. 5

Sea Urchin Morphogenesis., 1, 2016
McClay, DR, Current topics in developmental biology. 117 pp. 15-29

Left-right asymmetry in the sea urchin, 6, 2014
Warner, JF; McClay, DR, Genesis: the Journal of Genetics and Development. 52 vol. (6); pp. 481-487

Editorial-sea urchin special issue., 3, 2014
Angerer, LM, Genesis: the Journal of Genetics and Development. 52 vol. (3); pp. 157

Specification to biomineralization: following a single cell type as it constructs a skeleton., 10, 2014
Lyons, DC; Martik, ML; Saunders, LR; McClay, DR, Integrative and Comparative Biology (BioOne). 54 vol. (4); pp. 723-733

Branching out: Origins of the sea urchin larval skeleton in development and evolution, 1, 2014
Mcintyre, DC; Lyons, DC; Martik, M; Mcclay, DR, Genesis: the Journal of Genetics and Development. 52 vol. (3); pp. 173-185

Perturbations to the hedgehog pathway in sea urchin embryos., 1, 2014
Warner, JF; McClay, DR, Methods in molecular biology (Clifton, N.J.). 1128 pp. 211-221

Perturbations to the hedgehog pathway in sea urchin embryos, 0, 2014
Warner, JF; McClay, DR, Methods in molecular biology (Clifton, N.J.). 1128 pp. 211-221

Editorial-sea urchin special issue, 0, 2014
Ettensohn, CA; Burke, RD; Mcclay, DR, Genesis: the Journal of Genetics and Development. 52 vol. (3); pp. 157-157

Short-range Wnt5 signaling initiates specification of sea urchin posterior ectoderm, 12, 2013
Mcintyre, DC; Seay, NW; Croce, JC; McClay, DR, Development (Cambridge). 140 vol. (24); pp. 4881-4889

Perturbations to the Hh pathway in Sea Urchin Embryos, 2012
Warner, J., and D.R. McClay, Methods in Molecular Biology. (2012)

Frizzled 1/2/7 signaling directs beta catenin nuclearization and initiates endoderm specification in macromeres during sea urchin morphogenesis, 0, 2012
Lhomond, GD; McClay, R; Gache, C; Croce, JC, Development. 138 pp. 2639-2648

Morphogenesis in sea urchin embryos: linking cellular events to gene regulatory states., 2012
Lyons, DC; Kaltenbach, SL; McClay, DR, Wires Dev Biol. (2012) 1 pp. 231-252

Left-right asymmetry in the sea urchin embryo: BMP and the asymmetrical origins of the adult., 0, 2012
Warner, JF; Lyons, DC; McClay, DR, PLoS biology. 10 vol. (10); pp. e1001404

Evolutionary crossroads in developmental biology: sea urchins., 7, 2011
McClay, DR, Development (Cambridge). 138 vol. (13); pp. 2639-2648

The control of foxN2/3 expression in sea urchin embryos and its function in the skeletogenic gene regulatory network., 3, 2011
Rho, HK; McClay, DR, Development (Cambridge). 138 vol. (5); pp. 937-945

Wnt6 activates endoderm in the sea urchin gene regulatory network, 0, 2011
Croce, J; Range, R; Wu, S-Y; Miranda, E; Lhomond, G; Peng, JC-F; Lepage, T; McClay, DR, Development (Cambridge). 138 vol. (15); pp. 3297-3306

Cleavage and Gastrulation in the Sea Urchin., 0, 2011
McClay, DR, Encyclopedia of Life Sciences..

Dynamics of Delta/Notch signaling on endomesoderm segregation in the sea urchin embryo, 0, 2010
Croce, JC; McClay, DR, Development (Cambridge). 137 vol. (1); pp. 83-91

Hedgehog signaling patterns mesoderm in the sea urchin., 7, 2009
Walton, KD; Warner, J; Hertzler, PH; McClay, DR, Developmental Biology. 331 vol. (1); pp. 26-37

Roles of Dsh in the regulation of sea urchin gastrulation., 12, 2009
Byrum, CA; Bince, JM; Xu, RH; Illies, MH; McClay, DR; Ettensohn, C; Wikramanayake, AH, Dev Dyn. 238 vol. (7); pp. 1649-1665

Blocking dishevelled signaling in the noncanonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation, 0, 2009
Byrum, CA; Xu, R; Bince, JM; McClay, DR; Wikramanayake, AH, Developmental Dynamics. 238 vol. (7); pp. 1649-1665

Chordin is required for neural but not axial development in sea urchin embryos, 2008
Bradham, CA; Oikonomou, C; Kühn, A; Core, AB; Modell, JW; McClay, DR; Poustka, AJ, Developmental Biology. (2008) 328 vol. (2); pp. 221-233

Cleavage and Gastrulation in the Sea Urchin., 0, 2009
D.R. McClay,

Dynamics of the Delta/Notch Signaling on Endomesoderm Segregation in the Sea Urchin Embryo, 0, 2009
Croce, J.C. and D.R. McClay, Development.

LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo., 8, 2008
Range, RC; Glenn, TD; Miranda, E; McClay, DR, Development (Cambridge). 135 vol. (14); pp. 2445-2454

Twist is an essential regulator of the skeletogenic gene regulatory network in the sea urchin embryo., 2008
Wu, S-Y; Yang, Y-P; McClay, DR, Developmental Biology. (2008) 319 vol. (2); pp. 406-415

Lv-Numb promotes Notch-mediated specification of secondary mesenchyme cells in the sea urchin embryo, 12, 2008
Range, R; Glenn, T; McClay, DR, Development. 135 vol. (14); pp. 2445-2454

Erratum: FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development (Development vol. 135 (353-365)), 0, 2008
Röttinger, E; Saudemont, A; Duboc, V; Besnardeau, L; McClay, D; Lepage, T, Development (Cambridge). 135 vol. (4); pp. 785-

Evolution of the Wnt pathways., 2008
Croce, JC; McClay, DR, Methods in molecular biology (Clifton, N.J.). (2008) 469 pp. 3-18

Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development, 2008
Voronina, E; Lopez, M; Juliano, CE; Gustafson, E; Song, JL; Extavour, C; George, S; Oliveri, P; McClay, D; Wessel, G, Developmental Biology. (2008) 314 vol. (2); pp. 276-286

FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development, December, 2008
Röttinger, E; Sadumenont, A; Duboc, V; Besnardeau, L; McClay, D; Lepage, T, Development. (December, 2008) 135 vol. (2); pp. 353-365

The Snail repressor is required for PMC ingression in the sea urchin embryo., 3, 2007
Wu, S-Y; McClay, DR, Development. 134 vol. (6); pp. 1061-1070

Ingression of primary mesenchyme cells of the sea urchin embryo: a precisely timed epithelial mesenchymal transition., 12, 2007
Wu, S-Y; Ferkowicz, M; McClay, DR, Birth Defects Research Part C: Embryo Today: Reviews. 81 vol. (4); pp. 241-252

Secondary axis specification in sea urchin embryos, 0, 2007
Bradham, CA; McClay, DR, Signal Transduction. 7 vol. (2); pp. 181-186

RhoA regulates initiation of invagination, but not convergent extension, during sea urchin gastrulation., 4, 2006
Beane, WS; Gross, JM; McClay, DR, Dev Biol. 292 vol. (1); pp. 213-225

p38 MAPK in development and cancer., 4, 2006
Bradham, C; McClay, DR, Cell Cycle. 5 vol. (8); pp. 824-828

The canonical Wnt pathway in embryonic axis polarity., 4, 2006
Croce, JC; McClay, DR, Semin Cell Dev Biol. 17 vol. (2); pp. 168-174

Lineage-specific expansions provide genomic complexity among sea urchin GTPases., 12, 2006
Beane, WS; Voronina, E; Wessel, GM; McClay, DR, Dev Biol. 300 vol. (1); pp. 165-179

The sea urchin kinome: a first look., 12, 2006
Bradham, CA; Foltz, KR; Beane, WS; Arnone, MI; Rizzo, F; Coffman, JA; Mushegian, A; Goel, M; Morales, J; Geneviere, A-M; Lapraz, F; Robertson, AJ; Kelkar, H; Loza-Coll, M; Townley, IK; Raisch, M; Roux, MM; Lepage, T; Gache, C; McClay, DR; Manning, G, Dev Biol. 300 vol. (1); pp. 180-193

Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development., 12, 2006
Walton, KD; Croce, JC; Glenn, TD; Wu, S-Y; McClay, DR, Dev Biol. 300 vol. (1); pp. 153-164

A genome-wide survey of the evolutionarily conserved Wnt pathways in the sea urchin Strongylocentrotus purpuratus., 12, 2006
Croce, JC; Wu, S-Y; Byrum, C; Xu, R; Duloquin, L; Wikramanayake, AH; Gache, C; McClay, DR, Dev Biol. 300 vol. (1); pp. 121-131

Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions., 12, 2006
Byrum, CA; Walton, KD; Robertson, AJ; Carbonneau, S; Thomason, RT; Coffman, JA; McClay, DR, Dev Biol. 300 vol. (1); pp. 194-218

The genome of the sea urchin Strongylocentrotus purpuratus., 11, 2006
Sea Urchin Genome Sequencing Consortium, ; Sodergren, E; Weinstock, GM; Davidson, EH; Cameron, RA; Gibbs, RA; Angerer, RC; Angerer, LM; Arnone, MI; Burgess, DR; Burke, RD; Coffman, JA; Dean, M; Elphick, MR; Ettensohn, CA; Foltz, KR; Hamdoun, A; Hynes, RO; Klein, WH; Marzluff, W; McClay, DR; Morris, RL; Mushegian, A; Rast, JP; Smith, LC; Thorndyke, MC; Vacquier, VD; Wessel, GM; Wray, G; Zhang, L; Elsik, CG; Ermolaeva, O; Hlavina, W; Hofmann, G; Kitts, P; Landrum, MJ; Mackey, AJ; Maglott, D et al., Science. 314 vol. (5801); pp. 941-952

p38 MAPK is essential for secondary axis specification and patterning in sea urchin embryos., 1, 2006
Bradham, CA; McClay, DR, Development. 133 vol. (1); pp. 21-32

The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus, 0, 2006
Robertson, AJ; Croce, J; Carbonneau, S; Voronina, E; Miranda, E; McClay, DR; Coffman, JA, Dev Biol. 300 vol. (1); pp. 321-334

RTK and TGF-β signaling pathways genes in the sea urchin genome, 0, 2006
Lapraz, F; Röttinger, E; Duboc, V; Range, R; Duloquin, L; Walton, K; Wu, S-Y; Bradham, C; Loza, MA; Hibino, T; Wilson, K; Poustka, A; McClay, D; Angerer, L; Gache, C; Lepage, T, Dev Biol. 300 vol. (1); pp. 132-152

Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development, 0, 2006
Croce, J; Duloquin, L; Lhomond, G; McClay, DR; Gache, C, Development. 133 vol. (3); pp. 547-557

Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo, 0, 2006
Oliveri, P; Walton, KD; Davidson, EH; McClay, DR, Development. 133 vol. (21); pp. 4173-4181

SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects., 7, 2005
Deak, KL; Boyles, AL; Etchevers, HC; Melvin, EC; Siegel, DG; Graham, FL; Slifer, SH; Enterline, DS; George, TM; Vekemans, M; McClay, D; Bassuk, AG; Kessler, JA; Linney, E; Gilbert, JR; Speer, MC, Hum Genet. 117 vol. (2-3); pp. 133-142

A Fringe-modified Notch signal affects specification of mesoderm and endoderm in the sea urchin embryo., 6, 2005
Peterson, RE; McClay, DR, Dev Biol. 282 vol. (1); pp. 126-137

LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo., 3, 2005
Range, RC; Venuti, JM; McClay, DR, Dev Biol. 279 vol. (1); pp. 252-267

PI3K inhibitors block skeletogenesis but not patterning in sea urchin embryos., 4, 2004
Bradham, CA; Miranda, EL; McClay, DR, Developmental Dynamics. 229 vol. (4); pp. 713-721

Nuclear β-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages, 0, 2004
Wikramanayake, AH; Peterson, R; Chen, J; Huang, L; Bince, JM; McClay, DR; Klein, WH, Genesis. 39 vol. (3); pp. 194-205

Blastomere Isolation and Transplantation, 2004
Sweet, H; Amemiya, S; Ransick, A; Minokawa, T; McClay, DR; Wikramanayake, A; Kuraishi, R; Kiyomoto, M; Nishida, H; Henry, J, Methods in cell biology. (2004) 74 pp. 243-271

Methods for embryo dissociation and analysis of cell adhesion., 0, 2004
McClay, DR, Methods Cell Biol. 74 pp. 311-329

Mechanism of gastrulation in the Sea urchin., 0, 2004
McClay, D.R., Gross, J., Peterson, R. and C. Bradham, pp. 123-138.

SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis, 0, 2004
Otim, O; Amore, G; Minokawa, T; McClay, DR; Davidson, EH, Developmental Biology. 273 vol. (2); pp. 226-243

The Notch pathway in gastrulation., 0, 2004
McClay, D.R, Range, R. and Sherwood, D.R, pp. . 539-548

Selective expression of Wnt8 in vegetal cells of the early sea urchin embryo mediates endomesoderm specification in a nuclear beta-catenin-dependent manner, 0, 2004
Wikramanayake, AH; Peterson, R; Chen, J; Huang, L; McClay, DR; Klein, WH, Genesis. 39 vol. (3); pp. 194-205

SNPs in NCAM1 may be associated with human neural tube defects, 0, 2004
KL Bastress, HC Etchevers, AL Boyles, EC Melvin, DG Siegel, FL Graham, S Slifer, DS Enterline, TM George, M Vekemans, D McClay, AG Bassuk, JA Kessler, E Linney, JR Gilbert, M C Speer, Submitted.

Methods for embryo dissociation and for studying cell associations using sea urchin material, 0, 2004
McClay, DR, Methods of Cell Biology. 74 pp. 311-329

PI3K Activity is Required for Skeletogenesis in Sea Urchin Embryos., 0, 2004
Bradham, CA; Miranda, E; McClay, DR, Dev Dyn. 229 vol. (4); pp. 713-721

LvTbx2/3: a T-box family transcription factor involved in formation of the oral/aboral axis of the sea urchin embryo., 5, 2003
Gross, JM; Peterson, RE; Wu, S-Y; McClay, DR, Development (Cambridge). 130 vol. (9); pp. 1989-1999

Primary mesenchyme cell patterning during the early stages following ingression., 2, 2003
Peterson, RE; McClay, DR, Developmental Biology. 254 vol. (1); pp. 68-78

Activation of pmar1 controls specification of micromeres in the sea urchin embryo, 0, 2003
Oliveri, P; Davidson, EH; McClay, DR, Developmental Biology. 258 vol. (1); pp. 32-43

Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks, 0, 2003
Amore, G; Yavrouian, RG; Peterson, KJ; Ransick, A; McClay, DR; Davidson, EH, Developmental Biology. 261 vol. (1); pp. 55-81

Activation of pmar1 controls specification of micromeres in the sea urchin embryo, 0, 2003
Oliveri, PE; Davidson, H; McClay, DR, Dev. Biol. 258 vol. (1); pp. 25-38

Regulatory gene networks and the properties of the developmental process, 0, 2003
Davidson, EH; McClay, DR; Hood, L, Proceedings of the National Academy of Sciences of the United States of America. 100 vol. (4); pp. 1475-1480

A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo, 0, 2002
Davidson, EH; Rast, JP; Oliveri, P; Ransick, A; Calestani, C; Yuh, C-H; Minokawa, T; Amore, G; Hinman, V; Arenas-Mena, C; Otim, O; Brown, CT; Livi, CB; Lee, PY; Revilla, R; Schilstra, MJ; Clarke, PJC; Rust, AG; Pan, Z; Arnone, MI; Rowen, L; Cameron, RA; McClay, DR; Hood, L; Bolouri, H, Developmental Biology. 246 vol. (1); pp. 162-190

A genomic regulatory network for development, 0, 2002
Davidson, EH; Rast, JP; Oliveri, P; Ransick, A; Calestani, C; Yuh, C-H; Minokawa, T; Amore, G; Hinman, V; Arenas-Mena, C; Otim, O; Brown, CT; Livi, CB; Lee, PY; Revilla, R; Rust, AG; Pan, ZJ; Schilstra, MJ; Clarke, PJC; Arnone, MI; Rowen, L; Cameron, RA; McClay, DR; Hood, L; Bolouri, H, Science. 295 vol. (5560); pp. 1669-1678

LvNotch signaling plays a dual role in regulating the position of the ectoderm-endoderm boundary in the sea urchin embryo., 2001
Sherwood, DR; McClay, DR, Development (Cambridge). (2001) 128 vol. (12); pp. 2221-2232

Quantitative measurement of cell adhesion using centrifugal force., 5, 2001
McClay, DR; Hertzler, PL, Current Protocols in Cell Biology. Chapter 9 pp. Unit-9.2

The Role of Brachyruy (T) During Gastrulations Movement in the Sea Urchin, Lytechinus variegatus, 0, 2001
Gross, JM; McClay, DR, Developmental Biology. 239 pp. 232-247

A micromere induction signal is activated by beta-catenin and acts through notch to initiate specification of secondary mesenchyme cells in the sea urchin embryo., 12, 2000
McClay, DR; Peterson, RE; Range, RC; Winter-Vann, AM; Ferkowicz, MJ, Development (Cambridge). 127 vol. (23); pp. 5113-5122

Specification of endoderm and mesoderm in the sea urchin., 0, 2000
McClay, DR, Zygote. 8 Suppl 1 pp. S41

A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis, 0, 2000
Angerer, LM; Oleksyn, DW; Logan, CY; McClay, DR; Dale, L; Angerer, RC, Development (Cambridge). 127 vol. (5); pp. 1105-1114

LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo., 1999
Sherwood, DR; McClay, DR, Development (Cambridge). (1999) 126 vol. (8); pp. 1703-1713

alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo., 1999
Hertzler, PL; McClay, DR, Developmental Biology. (1999) 207 vol. (1); pp. 1-13

The role of thin filopodia in motility and morphogenesis., 2000
McClay, DR, Experimental Cell Research. (2000) 253 vol. (2); pp. 296-301

Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo., 1999
Logan, CY; Miller, JR; Ferkowicz, MJ; McClay, DR, Development (Cambridge). (1999) 126 vol. (2); pp. 345-357

Cortical granule exocytosis is triggered by different thresholds of calcium during fertilisation in sea urchin eggs., 1998
Matese, JC; McClay, DR, Zygote. (1998) 6 vol. (1); pp. 55-65a

A molecular analysis of hyalin - A substrate for cell adhesion in the hyaline layer of the sea urchin embryo, 1998
Wessel, GM; Berg, L; Adelson, DL; Cannon, G; McClay, DR, Developmental Biology. (1998) 193 vol. (2); pp. 115-126

Ectoderm cell-ECM interaction is essential for sea urchin embryo skeletogenesis, 1997
Zito, F; Tesoro, V; McClay, DR; Nakano, E; Matranga, V, Developmental Biology. (1997) 196 vol. (2); pp. 184-192

Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation., 1997
Sherwood, DR; McClay, DR, Development (Cambridge). (1997) 124 vol. (17); pp. 3363-3374

Regulated exocytosis and sequential construction of the extracellular matrix surrounding the sea urchin zygote., 1997
Matese, JC; Black, S; McClay, DR, Developmental Biology. (1997) 186 vol. (1); pp. 16-26

The allocation of early blastomeres to the ectoderm and endoderm is variable in the sea urchin embryo., 1997
Logan, CY; McClay, DR, Development (Cambridge). (1997) 124 vol. (11); pp. 2213-2223

Characterization of the role of cadherin in regulating cell adhesion during sea urchin development., 1997
Miller, JR; McClay, DR, Developmental Biology. (1997) 192 vol. (2); pp. 323-339

Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo., 1997
Miller, JR; McClay, DR, Developmental Biology. (1997) 192 vol. (2); pp. 310-322

Cellular migration, 1997
McClay, DR; Damsky, CH; Bronner-Fraser, M; Wylie, C; Bernfield, M; Markwald, RR, Reproductive Toxicology. (1997) 11 vol. (2-3); pp. 321-329

Molecular cloning of the first metazoan beta-1,3 glucanase from eggs of the sea urchin Strongylocentrotus purpuratus., 6, 1996
Bachman, ES; McClay, DR, Proceedings of the National Academy of Sciences of USA. 93 vol. (13); pp. 6808-6813

Regulative capacity of the archenteron during gastrulation in the sea urchin., 1996
McClay, DR; Logan, CY, Development (Cambridge). (1996) 122 vol. (2); pp. 607-616

Characterization of moesin in the sea urchin Lytechinus variegatus: redistribution to the plasma membrane following fertilization is inhibited by cytochalasin B., 1, 1995
Bachman, ES; McClay, DR, Journal of cell science. 108 ( Pt 1) pp. 161-171

Dynamics of thin filopodia during sea urchin gastrulation, 1995
Miller, J; Fraser, SE; McClay, D, Development. (1995) 121 vol. (8); pp. 2501-2511

Cell adhesion and cell signaling at gastrulation in the sea urchin, 1995
McClay, DR; Miller, JR; Logan, CY; Hertzler, PL; Bachman, ES; Matese, JC; Sherwood, DR; Armstrong, NA, Theriogenology. (1995) 44 vol. (8); pp. 1145-1165

Skeletal pattern is specified autonomously by the primary mesenchyme cells in sea urchin embryos., 1994
Armstrong, N; McClay, DR, Developmental Biology. (1994) 162 vol. (2); pp. 329-338

Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid., 1994
Burdsal, CA; Lotz, MM; Miller, J; McClay, DR, Developmental Dynamics. (1994) 201 vol. (4); pp. 344-353

The establishment of bilateral asymmetry in sea urchin embryos, 1994
McCain, ER; McClay, DR, Development. (1994) 120 vol. (2); pp. 395-404

Cell-cell interactions regulate skeleton formation in the sea urchin embryo., 1993
Armstrong, N; Hardin, J; McClay, DR, Development (Cambridge). (1993) 119 vol. (3); pp. 833-840

Deployment of extracellular matrix proteins in sea urchin embryogenesis., 1992
Alliegro, MC; Black, SD; McClay, DR, Microscopy Research and Technique. (1992) 22 vol. (1); pp. 2-10

On the ultrastructure of hyalin, a cell adhesion protein of the sea urchin embryo extracellular matrix., 1992
Adelson, DL; Alliegro, MC; McClay, DR, The Journal of Cell Biology. (1992) 116 vol. (5); pp. 1283-1289

Commitment along the dorsoventral axis of the sea urchin embryo is altered in response to NiCl<sub>2</sub>, 1992
Hardin, J; Coffman, JA; Black, SD; McClay, DR, Development (Cambridge). (1992) 116 vol. (3); pp. 671-685

Pattern formation during gastrulation in the sea urchin embryo, 1992
McClay, DR; Armstrong, NA; Hardin, J, Development. (1992) 115 vol. (1 SUPPL.); pp. 33-41

Gastrulation., 1991
McClay, DR, Current Opinion in Genetics & Development. (1991) 1 vol. (2); pp. 191-195

Tissue-specific, temporal changes in cell adhesion to echinonectin in the sea urchin embryo., 1991
Burdsal, CA; Alliegro, MC; McClay, DR, Developmental Biology. (1991) 144 vol. (2); pp. 327-334

A hyaline layer protein that becomes localized to the oral ectoderm and foregut of sea urchin embryos., 1990
Coffman, JA; McClay, DR, Developmental Biology. (1990) 140 vol. (1); pp. 93-104

In vitro biological activities of echinonectin., 1990
Alliegro, MC; Burdsal, CA; McClay, DR, Biochemistry. (1990) 29 vol. (8); pp. 2135-2141

Target recognition by the archenteron during sea urchin gastrulation., 1990
Hardin, J; McClay, DR, Developmental Biology. (1990) 142 vol. (1); pp. 86-102

Neuronal-glial interactions: complexity of neurite outgrowth correlates with substrate adhesivity of serotonergic neurons., 1990
Lieth, E; McClay, DR; Lauder, JM, Glia. (1990) 3 vol. (3); pp. 169-179

Embryonic cellular organization: differential restriction of fates as revealed by cell aggregates and lineage markers., 1989
Bernacki, SH; McClay, DR, Journal of Experimental Zoology. (1989) 251 vol. (2); pp. 203-216

Cell adhesion to fibronectin and tenascin: Quantitative measurements of initial binding and subsequent strengthening response, 1989
Lotz, MM; Burdsal, CA; Erickson, HP; McClay, DR, Journal of Cell Biology. (1989) 109 vol. (4 I); pp. 1795-1805

The origin of spicule-forming cells in a 'primitive' sea urchin (Eucidaris tribuloides) which appears to lack primary mesenchyme cells., 1988
Wray, GA; McClay, DR, Development (Cambridge). (1988) 103 vol. (2); pp. 305-315

Cell polarity in sea urchin embryos: reorientation of cells occurs quickly in aggregates., 1988
Nelson, SH; McClay, DR, Developmental Biology. (1988) 127 vol. (2); pp. 235-247

Cell lineage conversion in the sea urchin embryo., 1988
Ettensohn, CA; McClay, DR, Developmental Biology. (1988) 125 vol. (2); pp. 396-409

Storage and mobilization of extracellular matrix proteins during sea urchin development., 1988
Alliegro, MC; McClay, DR, Developmental Biology. (1988) 125 vol. (1); pp. 208-216

Echinonectin: A new embryonic substrate adhesion protein, 1988
Alliegro, MC; Ettensohn, CA; Burdsal, CA; Erickson, HP; McClay, DR, Journal of Cell Biology. (1988) 107 vol. (6 I); pp. 2319-2327

A cortical granule-specific enzyme, B-1,3-glucanase, in sea urchin eggs., 1987
Wessel, GM; Truschel, MR; Chambers, SA; McClay, DR, Gamete Research. (1987) 18 vol. (4); pp. 339-348

Stage-specific expression of beta-1, 3-glucanase in sea urchin embryos and hybrids., 1987
Peeler, MT; Chambers, SA; Wang, CY; McClay, DR, Journal of Experimental Zoology. (1987) 244 vol. (2); pp. 215-222

A new method for isolating primary mesenchyme cells of the sea urchin embryo. Panning on wheat germ agglutinin-coated dishes, 1987
Ettensohn, CA; McClay, DR, Experimental Cell Research. (1987) 168 vol. (2); pp. 431-438

Gastrulation in the sea urchin embryo requires the deposition of crosslinked collagen within the extracellular matrix, 1987
Wessel, GM; McClay, DR, Developmental Biology. (1987) 121 vol. (1); pp. 149-165

Cell adhesion in morphogenesis., 1987
McClay, DR; Ettensohn, CA, Annual Review of Cell Biology. (1987) 3 pp. 319-345

Two embryonic, tissue-specific molecules identified by a double-label immunofluorescence technique for monoclonal antibodies, 0, 1986
Wessel, GM; McClay, DR, Journal of Histochemistry and Cytochemistry. 34 vol. (6); pp. 703-706

Embryo dissociation, cell isolation, and cell reassociation., 0, 1986
McClay, DR, Methods in cell biology. 27 pp. 309-323

Two antigenically distinct forms of β-1,3-glucanase in sea urchin embryonic development, 0, 1986
Truschel, MR; Chambers, SA; McClay, DR, Developmental Biology. 117 vol. (1); pp. 277-285

The regulation of primary mesenchyme cell migration in the sea urchin embryo: Transplantations of cells and latex beads, 1986
Ettensohn, CA; McClay, DR, Developmental Biology. (1986) 117 vol. (2); pp. 380-391

On the role of calcium in the adhesion of embryonic sea urchin cells, 0, 1986
McClay, DR; Matranga, V, Experimental Cell Research. 165 vol. (1); pp. 152-164

Sequential expression of germ-layer specific molecules in the sea urchin embryo, 1985
Wessel, GM; McClay, DR, Developmental Biology. (1985) 111 vol. (2); pp. 451-463

Three cell recognition changes accompany the ingression of sea urchin primary mesenchyme cells, 0, 1985
Fink, RD; McClay, DR, Developmental Biology. 107 vol. (1); pp. 66-74

The surface of the sea urchin embryo at gastrulation: a molecular mosaic, 0, 1985
McClay, DR; Wessel, GM, Trends in Genetics. 1 vol. (C); pp. 12-16

Cell recognition processes in the differentiation of embryonic sea urchins., 1984
Fink, RD; McClay, DR, Progress in clinical and biological research. (1984) 157 pp. 143-148

Ontogeny of the basal lamina in the sea urchin embryo, 1984
Wessel, GM; Marchase, RB; McClay, DR, Developmental Biology. (1984) 103 vol. (1); pp. 235-245

A molecularanalysis of hyalin, the major component of the cortical granules that is secreted at fertilization of the sea urchin egg., 12, 1983
Wessel, GM; Berg, L; Adelson, D; Cannon, G; McClay, DR, Dev. Biol. 193 pp. 115-126

Sea urchin hyalin: Appearance and function in development, 1982
McClay, DR; Fink, RD, Developmental Biology. (1982) 92 vol. (2); pp. 285-293

Calcium-dependent and calcium-independent adhesive mechanisms are present during initial binding events of neural retina cells, 1982
McClay, DR; Marchase, RB, Journal of Cellular Biochemistry. (1982) 18 vol. (4); pp. 469-478

Retinal ligatin recognizes glycoproteins bearing oligosaccharides terminating in phosphodiester-linked glucose, 1982
Marchase, RB; Koro, LA; Kelly, CM; McClay, DR, Cell. (1982) 28 vol. (4); pp. 813-820

Cell recognition during gastrulation in the sea urchin, 0, 1982
McClay, DR, Cell Differentiation. 11 vol. (5-6); pp. 341-344

A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion, 0, 1982
Marchase, RB; Koro, LA; Kelly, CM; McClay, DR, Journal of Cellular Biochemistry. 18 vol. (4); pp. 461-468

Intercellular recognition: Quantitation of initial binding events, 1981
McClay, DR; Wessel, GM; Marchase, RB, Proceedings of the National Academy of Sciences of the United States of America. (1981) 78 vol. (8 I); pp. 4975-4979

Cortical reorganization following fertilization of sea urchin eggs: Sensitivity to cytochalasin B, 1980
Banzhaf, WC; Warren, RH; McClay, DR, Developmental Biology. (1980) 80 vol. (2); pp. 506-515

Separation of ectoderm and endoderm from sea urchin pluteus larvae and demonstration of germ layer-specific antigens, 1979
McClay, DR; Marchase, RB, Developmental Biology. (1979) 71 vol. (2); pp. 289-296

Chapter 9 Surface Antigens Involved in Interactions of Embryonic Sea Urchin Cells, 0, 1979
McClay, DR, Current topics in developmental biology. 13 vol. (C); pp. 199-214

Identification of four classes of cell surface antigens appearing at gastrulation in sea urchin embryos, 1978
McClay, DR; Chambers, AF, Developmental Biology. (1978) 63 vol. (1); pp. 179-186

Involvement of histocompatibility antigens in embryonic cell recognition events, 1978
McClay, DR; Gooding, LR, Nature. (1978) 274 vol. (5669); pp. 367-368

Specificity of cell-cell interactions in sea urchin embryos. Appearance of new cell-surface determinants at gastrulation, 1977
McClay, DR; Chambers, AF; Warren, RH, Developmental Biology. (1977) 56 vol. (2); pp. 343-355

A requirement for trypsin-sensitive cell-surface components for cell-cell interactions of embryonic neural retina cells, 1977
McClay, DR; Gooding, LR; Fransen, ME, Journal of Cell Biology. (1977) 75 vol. (1); pp. 56-66

Specificity of cell adhesion: Differences between normal and hybrid sea urchin cells, 1975
McClay, DR; Hausman, RE, Developmental Biology. (1975) 47 vol. (2); pp. 454-460

A kinetic study of embryonic cell adhesion, 0, 1975
McClay, DR; Baker, SR, Developmental Biology. 43 vol. (1); pp. 109-122

Purification of the specific cell-aggregating factor from embryonic neural retina cells, 1974
McClay, DR; Moscona, AA, Experimental Cell Research. (1974) 87 vol. (2); pp. 438-443

Cell aggregation: properties of cell surface factors from five species of sponge, 1974
McClay, DR, Journal of Experimental Zoology. (1974) 188 vol. (1); pp. 89-102

Papers Submitted

Delayed transition to new cell fates during cellular reprogramming. in Developmental Biology 7, 2014
Cheng, X; Lyons, DC; Socolar, JES; McClay, DR

Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition. in Development (Cambridge) 4, 2014
Saunders, LR; McClay, DR

Awards

  • 2006 Viktor Hamburger Memorial Speaker Award, Washington University, St. Louis

  • 2005 NIH Career Development Award, NIH

  • 2005 NIH Postdoctoral Fellowship, NIH

  • 2005 NSF Continuing Student Stipend in Embryolog, NSF

  • 2005 NASA Predoctoral Fellowship, NASA

  • 2004 Arthur S. Pearse Professorship of Biology

  • 1991 Fellow, American Academy of Arts and Sciences

  • 1989 Duke University Undergraduate Outstanding Teaching Award, Duke University

  • 1968 NSF Scholarship, NSF