The unification of genomic data, bioinformatic analysis, and evolutionary theory has transformed our understanding of human history, our place within the Tree of Life, and the impact that our species is having on those with whom we share the planet. This course will draw from the primary literature to familiarize students with the multifaceted power of genomics, with a slant towards examining human history and disease from an evolutionary perspective. Readings will be drawn from a wide variety of sources, from some published more than a century ago, up through the contemporary popular press. Recommended prerequisite: Biology 202L.