Overview of the genetic changes associated with cancer and the molecular events that transform normal cellular processes into tumor-promoting conditions. Topics include: tumor viruses, oncogenes, growth factors, signal transduction pathways, tumor suppressors, cell cycle control, apoptosis, genome instability, stem cells, metastasis, and current therapeutic approaches. Prerequisites: Biology 201L and either Biology 219 or Biology 202L. One course.
Readings by and about Darwin and his contemporaries, especially Wallace. Darwin's "Autobiography" and Janet Browne's biography as context for readings of some of his major works and works of his contemporaries. Consent of instructor required. One course. 3 graduate units.
Formulation of environmental models and applications to data using R. Distribution theory, algorithms, and implementation. Topics include physiology, population growth, species interactions, disturbance, and ecosystem dynamics. Discussions focus on classical and current primary literature. Instructor: J. Clark. One course. 3 graduate units.
Key questions in population ecology from a theoretical perspective. Topics include demography and dynamics of structured populations, population regulation, stochastic and spatial population dynamics, life history characteristics, species interactions, and conservation of threatened populations. Computer labs will emphasize fitting models to data. Prerequisites: One course in Ecology. One course. 3 graduate units.
Computer programming using C within a UNIX environment applied to ecological and evolutionary problems. The relationship between simulation and analytic modeling. Knowledge of programming or work within the UNIX computer environment not expected. Consent of instructor required. One course. 3 graduate units.
One course. 3 graduate units.
Lectures, seminars, and discussion of current topics in developmental biology. Prerequisites: Biology 201L or 202L and/or 220 or equivalent. One course.
Experimental approaches in devel- opment and genetics using animal and plant models. Laboratory training in molecular genetics, immunochemistry, microscopy, protein chemistry, and genetic screening. Experiments include immunochemical localization, in situ hybridization, polymerase chain reaction, genetic screening, embryo micromanipulation, microscopic imaging, and mutant analysis. Prerequisite: Biology 201L or 202L; recommended, prior or concurrent registration in Biology 220. One course.
Recent progress in sensory signal transduction mediated by calcium channels and receptors. Topics include history and techniques in the study of ion channels, such as electrophysiology, calcium imaging, and cell and molecular biology; cell surface perception for external signals, including light receptors, olfactory receptors, taste receptors, hot and cold receptors, and mechanical receptors; heart and brain pacemakers; sensory channel receptor-related human diseases; and plan sensory signaling network. One course.