Physiological Genetics of Disease

An exploration of how we have come to understand the relationships between genes and traits, with a focus on traits of biomedical importance. We explore how physiological systems biology can be used to understand the causal pathways by which genes affect traits. Examples will be taken largely from the biomedical literature with a focus on genetic diseases and the roles of genetic background and environment in determining how (and why) genes affect traits. Readings and class participation, short papers and oral presentations on research projects. Nijhout

Genomics of Adaptation: A Modern Look at Evolution

Contemporary studies of how populations and species evolved adaptations to their ecological habitats. Focus on modern methods of genome mapping and sequence data and analysis in wild populations that can identify genetic changes that contributed to ecological adaptations. Emphasis on case studies of genomics of adaptation in plant and animal systems, including humans and our adaptations to environments that our ancestors encountered as they colonized diverse habitats throughout the world.

Microbial Ecology and Evolution

Survey of new advances in the field of environmental and evolu- tionary microbiology, based on current literature, discussion, and laboratory exercises. Topics to include bacterial phylogeny, molecular ecology, emerging infectious diseases, bacterial symbiosis, experimental evolution, evolution of drug resistance, and microbial genomics. Prerequisite: Biology 20 or 212L or 201L or 202L. One course. 4 graduate units.

Systematic Biology

Laboratory version of Biology 556. Theory and practice of identification, species discovery, phylogeny reconstruction, classification, and nomenclature. Prerequisite: Biology 202L or equivalent. One course. 4 graduate units.