Quantitative understanding of biological systems through the application of physical principles. Course will emphasize topics that span multiple length and time scales, and different levels of biological organization. Two to four topics per semester, including possibly organismal motion from molecular processes to whole organisms, nervous systems from membrane channels to neuronal networks, noise in biology, novel biophysical technologies, etc. Prerequisite: Biology 201L, Mathematics 212 and 216 or equivalent, and calculus based introductory physics or permission of the instructors.
The biology, ecology, and evolution of tropical diseases and how emerging diseases are expanding their range and virulence. Environmental changes in the tropics such as climate change and land conversion impacting ecosystem and human health including: diseases, cultural medicinal practices, and changes in ecosystem functions. Based at the three OTS biological field stations in Costa Rica and surrounding landscapes. Intact and altered ecosystems impacts on human health, including assessments of insect and water-borne disease vectors.
Gain skills necessary to conduct neuroscience research and integrate findings from multiple levels of analysis (molecular, cellular and behavioral). Team-based learning format and collaboration with neuroscience lab to generate, analyze, and communicate novel scientific findings. Experimentation will occur in a model organism and may include PCR, live cell imaging and/or behavioral conditioning experiments. Prerequisite: Neuroscience 101.
How theory and experimental techniques from physics can be used to analyze and understand biological structure and function, including chemical, mechanical, electrical, collective, and information-processing aspects. Prerequisites: Biology 201L and knowledge of statistical physics by taking either Physics 363 or Chemistry 311.
From sleep/wake cycles to flower opening to cell division and malaria infections; all organisms and cells display rhythmic behaviors. Course will focus on genetic and molecular networks that comprise clocks regulating cell division and circadian rhythms. Quantitative aspects clock networks will be examined from the perspective of data analysis and dynamical models. Class will include lectures, primary literature readings, and in-class projects. Prerequisites: Math 112L or equivalent, and Biology 20 or Biology 201L. Instructor: Haase and Harer
Ecology/biodiversity and conservation in Alaska: identification and natural history of native plants and animals including both terrestrial and marine species, biogeographic history and patterns, native American cultures, conservation issues surrounding Alaskan natural resources. Regional, national, and geopolitical issues surrounding development and conservation in Alaska and elsewhere in the arctic.
An exploration of how we have come to understand the relationships between genes and traits, with a focus on traits of biomedical importance. We explore how physiological systems biology can be used to understand the causal pathways by which genes affect traits. Examples will be taken largely from the biomedical literature with a focus on genetic diseases and the roles of genetic background and environment in determining how (and why) genes affect traits. Readings and class participation, short papers and oral presentations on research projects. Nijhout