How do diverse biological sensory and regulatory mechanisms integrate dynamic environmental signals for adaptation
and survival in fluctuating environments?
- Our working hypothesis is that transcription factors and posttranscriptional effectors work in concert via a
complex network to manifest emergent properties which bring about the appropriate response to changing conditions
to enable survival.
- To test this, we study archaeal extremophiles using systems approaches to characterize the regulation of
cellular physiology in response to varying environmental stressors encountered at the limits of sustainable life.
- Ultimately, we aim to develop transcriptional and posttranscriptional regulatory network models for the
quantitative prediction of induced phenotypic changes at these extremes.
- Research toward these goals will lay the foundation for rational re-engineering of cellular physiology for desired
outcomes such as targeted industrial, environmental and medical purposes.