Zhen-Ming Pei

Associate Professor of Biology

Office: 
3102 Ffsc, Duke University, Durham, NC 27708-1000
Campus Box: 
90338
Phone: 
(919) 613-8152
Fax: 
919-613-8177

Research Interests: 

My laboratory is interested in the early signaling events by which plants sense environmental signals and decode to give the appropriate responses. Upon perception of external signals, cell surface receptors trigger an increase in cytosolic free calcium concentration, which is mediated by ion channels. Our long-term goals are to identify these receptors and ion channels, isolate their interacting components, and assign molecular functions to them. Currently, we are using multidisciplinary approaches of biophysics, biochemistry, cell biology, molecular genetics, and function genomics to dissect the signaling cascades of external calcium as well as nitric oxide in the model plant Arabidopsis.

My laboratory is interested in the early signaling events by which plants sense environmental signals and decode to give the appropriate responses. Upon perception of external signals, cell surface receptors trigger an increase in cytosolic free calcium concentration, which is mediated by ion channels. Our long-term goals are to identify these receptors and ion channels, isolate their interacting components, and assign molecular functions to them. Currently, we are using multidisciplinary approaches of biophysics, biochemistry, cell biology, molecular genetics, and function genomics to dissect the signaling cascades of external calcium as well as nitric oxide in the model plant Arabidopsis.

Education

  • Ph.D. 1993, Shanghai Institute of Plant Physiology

  • M.S. 1990, Fudan University (China)

  • B.S. 1985, Lanzhou University (China)

Papers Published

Biotic and Abiotic Stresses Activate Different Ca(2+) Permeable Channels in Arabidopsis., 1, 2017
Cao, X-Q; Jiang, Z-H; Yi, Y-Y; Yang, Y; Ke, L-P; Pei, Z-M; Zhu, S, Frontiers in Plant Science. 8 pp. 83

L-Met Activates Arabidopsis GLR Ca(2+) Channels Upstream of ROS Production and Regulates Stomatal Movement., 12, 2016
Kong, D; Hu, H-C; Okuma, E; Lee, Y; Lee, HS; Munemasa, S; Cho, D; Ju, C; Pedoeim, L; Rodriguez, B; Wang, J; Im, W; Murata, Y; Pei, Z-M; Kwak, JM, Cell Reports. 17 vol. (10); pp. 2553-2561

Corrigendum: OSCA1 mediates osmotic-stress-evoked Ca(2+) increases vital for osmosensing in Arabidopsis., 2, 2015
Yuan, F; Yang, H; Xue, Y; Kong, D; Ye, R; Li, C; Zhang, J; Theprungsirikul, L; Shrift, T; Krichilsky, B; Johnson, DM; Swift, GB; He, Y; Siedow, JN; Pei, ZM, Nature.

Genome-wide survey and expression analysis of the OSCA gene family in rice., 1, 2015
Li, Y; Yuan, F; Wen, Z; Li, Y; Wang, F; Zhu, T; Zhuo, W; Jin, X; Wang, Y; Zhao, H; Pei, Z-M; Han, S, BMC Plant Biology. 15 pp. 261

Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING., 7, 2014
Wu, X; Wu, F-H; Wang, X; Wang, L; Siedow, JN; Zhang, W; Pei, Z-M, Nucleic Acids Research. 42 vol. (13); pp. 8243-8257

Proteome and calcium-related gene expression in Pinus massoniana needles in response to acid rain under different calcium levels, 7, 2014
Hu, W-J; Chen, J; Liu, T-W; Wu, Q; Wang, W-H; Liu, X; Shen, Z-J; Simon, M; Chen, J; Wu, F-H; Pei, Z-M; Zheng, H-L, Plant and Soil. 380 vol. (1-2); pp. 285-303

OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis., 10, 2014
Yuan, F; Yang, H; Xue, Y; Kong, D; Ye, R; Li, C; Zhang, J; Theprungsirikul, L; Shrift, T; Krichilsky, B; Johnson, DM; Swift, GB; He, Y; Siedow, JN; Pei, Z-M, Nature. 514 vol. (7522); pp. 367-371

Proteome and calcium-related gene expression in Pinus massoniana needles in response to acid rain under different calcium levels, 1, 2014
Hu, WJ; Chen, J; Liu, TW; Wu, Q; Wang, WH; Liu, X; Shen, ZJ; Simon, M; Chen, J; Wu, FH; Pei, ZM; Zheng, HL, Plant and Soil. 380 vol. (1); pp. 285-303

Cytokinins can act as suppressors of nitric oxide in Arabidopsis, 0, 2013
Liu, W-Z; Kong, D-D; Gu, X-X; Gao, H-B; Wang, J-Z; Xia, M; Gao, Q; Tian, L-L; Xu, Z-H; Bao, F; Hu, Y; Ye, N-S; Pei, Z-M; He, Y-K, Proc Natl Acad Sci U S A. 110 vol. (4); pp. 1548-1553

Improving the Measurement of Semantic Similarity between Gene Ontology Terms and Gene Products: Insights from an Edge- and IC-Based Hybrid Method, March, 2013
Wu, X; Pang, E; Lin, K; Pei, Z-M, PLoS One. (March, 2013) 8 vol. (5); pp. e66745

Relationship between NaCl- and H<sub>2</sub>O<sub>2</sub>-Induced Cytosolic Ca<sup>2+</sup> Increases in Response to Stress in Arabidopsis, 0, 2013
Jiang, Z; Zhu, S; Ye, R; Xue, Y; Chen, A; An, L; Pei, Z-M, PloS one. 8 vol. (10);

Calcium and calcium receptor CAS promote Arabidopsis thaliana de-etiolation, 0, 2012
Huang, S-S; Chen, J; Dong, X-J; Patton, J; Pei, Z-M; Zheng, H-L, Physiologia Plantarum. 144 vol. (1); pp. 73-82

Calcium-sensing receptor regulates stomatal closure through hydrogen peroxide and nitric oxide in response to extracellular calcium in Arabidopsis, 0, 2012
Wang, W-H; Yi, X-Q; Han, A-D; Liu, T-W; Chen, J; Wu, F-H; Dong, X-J; He, J-X; Pei, Z-M; Zheng, H-L, Journal of Experimental Botany. 63 vol. (1); pp. 177-190

RETRACTED ARTICLE: A 2-D DIGE analysis of simulated acid rain-responsive proteins in Pinus massoniana needles, 0, 2012
Liu, T-W; Hu, W-J; Wang, X-Q; Niu, L; Fu, B; Wu, F-H; Pei, Z-M; Zheng, H-L, Trees. 26 vol. (5); pp. 1677-

Emissions of nitric oxide from 79 plant species in response to simulated nitrogen deposition, 0, 2012
Chen, J; Wu, F-H; Liu, T-W; Chen, L; Xiao, Q; Dong, X-J; He, J-X; Pei, Z-M; Zheng, H-L, Environmental Pollution. 160 vol. (1); pp. 192-200

Comparative proteomic analysis of differentially expressed proteins in β-aminobutyric acid enhanced Arabidopsis thaliana tolerance to simulated acid rain., 5, 2011
Liu, T; Jiang, X; Shi, W; Chen, J; Pei, Z; Zheng, H, Proteomics. 11 vol. (10); pp. 2079-2094

Effects of calcium on seed germination, seedling growth and photosynthesis of six forest tree species under simulated acid rain, 0, 2011
Liu, T-W; Wu, F-H; Wang, W-H; Chen, J; Li, Z-J; Dong, X-J; Patton, J; Pei, Z-M; Zheng, H-L, Tree Physiology. 31 vol. (4); pp. 402-413

Effect of salinity on osmotic adjustment characteristics of Kandelia candel, 0, 2011
Zhu, Z; Pei, ZM; Zheng, HL, Russian Journal of Plant Physiology. 58 vol. (2); pp. 226-232

Comparative proteomic analysis of proteins in response to simulated acid rain in Arabidopsis, 0, 2011
Liu, T-W; Fu, B; Niu, L; Chen, J; Wang, W-H; He, J-X; Pei, Z-M; Zheng, H-L, Journal of Proteome Research. 10 vol. (5); pp. 2579-2589

The changes of nitric oxide production during the growth of Microcystis aerugrinosa, 0, 2011
Tang, X; Chen, J; Wang, W-H; Liu, T-W; Zhang, J; Gao, Y-H; Pei, Z-M; Zheng, H-L, Environmental Pollution. 159 vol. (12); pp. 3784-3792

Hydrogen sulphide enhances photosynthesis through promoting chloroplast biogenesis, photosynthetic enzyme expression, and thiol redox modification in Spinacia oleracea seedlings, 0, 2011
Chen, J; Wu, F-H; Wang, W-H; Zheng, C-J; Lin, G-H; Dong, X-J; He, J-X; Pei, Z-M; Zheng, H-L, Journal of Experimental Botany. 62 vol. (13); pp. 4481-4493

Nitric oxide enhances salt secretion and Na(+) sequestration in a mangrove plant, Avicennia marina, through increasing the expression of H(+)-ATPase and Na(+)/H(+) antiporter under high salinity., 12, 2010
Chen, J; Xiao, Q; Wu, F; Dong, X; He, J; Pei, Z; Zheng, H, Tree Physiology. 30 vol. (12); pp. 1570-1585

Calcuim depletion in forest ecosystem induced by acid rain: A review, 0, 2010
Wu, F; Liu, T; Pei, Z; Zheng, H, Acta Ecologica Sinica. 30 vol. (4); pp. 1081-1088

Nitric oxide emission from barley seedlings and detached leaves and roots treated with nitrate and nitrite, 0, 2010
Chen, J; Xiao, Q; Wu, E; Pei, ZM; Wang, J; Wu, YG; Zheng, HL, Plant, soil and environment / Czech Academy of Agricultural Sciences. 56 vol. (5); pp. 201-208

Soil acidity reconstruction based on tree ring information of a dominant species Abies fabri in the subalpine forest ecosystems in southwest China, 0, 2010
Chen, L; Wu, F-H; Liu, T-W; Chen, J; Li, Z-J; Pei, Z-M; Zheng, H-L, Environmental Pollution. 158 vol. (10); pp. 3219-3224

Diurnal variation of nitric oxide emission flux from a mangrove wetland in Zhangjiang River Estuary, China, 0, 2010
Chen, J; Wu, F-H; Xiao, Q; Yang, Z-H; Huang, S-K; Wang, J; Wu, Y-G; Dong, X-J; Pei, Z-M; Zheng, H-L, Estuarine, Coastal and Shelf Science. 90 vol. (4); pp. 212-220

Eco-physiological effect of calcium imbalance caused by environmental acidification; A review, 0, 2009
Wu, F-H; Pei, Z-M; Zheng, H-L, Chinese Journal of Ecology. 28 vol. (7); pp. 1373-1380

Effects of environmental stress on nitric oxide emission from Hordeum vulgare seedlings, 0, 2009
Chen, J; Xiao, Q; Wu, FH; Pei, ZM; Zheng, HL, Chinese Journal of Ecology. 28 vol. (10); pp. 1971-1976

Short- and long-term effects of NaCl on physiological and biochemical characteristics in leaves of a true mangrove, Kandelia candel, 0, 2009
Ru, QM; Xiao, Q; Lin, P; Pei, ZM; Zheng, HL, Russian Journal of Plant Physiology. 56 vol. (3); pp. 363-369

Exploring the mechanism of Physcomitrella patens desiccation tolerance through a proteomic strategy <sup>1[W][OA]</sup>, 0, 2009
Wang, XQ; Yang, PF; Liu, Z; Liu, WZ; Hu, Y; Chen, H; Kuang, TY; Pei, ZM; Shen, SH; He, YK, Plant physiology. 149 vol. (4); pp. 1739-1750

Microwave-assisted extraction and identification of polysaccharide from Lycoris aurea, 0, 2009
Ru, QM; Zhang, LR; Chen, JD; Pei, ZM; Zheng, HL, Chemistry of Natural Compounds. 45 vol. (4); pp. 474-477

The signal transduction of nitric oxide in plants, 0, 2008
Liu, WZ; Zhang, RJ; Pei, ZM; He, YK, Prog Nat Sci. 18 vol. (1); pp. 10-24

Calcium signals and their regulation, 0, 2008
Pei, ZM; Gilroy, S, Annual Plant Reviews: Intracellular Signaling in Plants. 33 pp. 137-162

In vitro studies on antioxidant and antimicrobial activities of polysaccharide from Lycoris aurea, 0, 2008
Ru, Q-M; Pei, Z-M; Zheng, H-L, Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 31 vol. (10); pp. 1536-1540

Coupling diurnal cytosolic Ca2+ oscillations to the CAS-IP3 pathway in Arabidopsis., 3, 2007
Tang, R-H; Han, S; Zheng, H; Cook, CW; Choi, CS; Woerner, TE; Jackson, RB; Pei, Z-M, Science. 315 vol. (5817); pp. 1423-1426

Extracellular Ca2+ signaling: first messenger in animals and plants, 0, 2007
Zhao, X; Pei, Z-M; He, Y-K, Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji.. 29 vol. (3); pp. 269-275

Nitric Oxide Alleviates Oxidative Stress Caused by Lanthanum in Rice Leaves, 0, 2007
Qiang, X; Qiaomei, R; Feihua, W; Xuan, H; Zhenming, P; Hailei, Z, Journal of Rare Earths. 25 vol. (5); pp. 631-636

Early ABA signaling events in guard cells, 0, 2005
Pei, ZM; Kuchitsu, K, Journal of Plant Growth Regulation. 24 vol. (4); pp. 296-307

Nitric oxide represses the Arabidopsis floral transition., 9, 2004
He, Y; Tang, R-H; Hao, Y; Stevens, RD; Cook, CW; Ahn, SM; Jing, L; Yang, Z; Chen, L; Guo, F; Fiorani, F; Jackson, RB; Crawford, NM; Pei, Z-M, Science. 305 vol. (5692); pp. 1968-1971

A cell surface receptor mediates extracellular Ca(2+) sensing in guard cells., 2003
Han, S; Tang, R; Anderson, LK; Woerner, TE; Pei, Z-M, Nature. (2003) 425 vol. (6954); pp. 196-200

NADPH oxidase AtrbohD and AtrbohF genes function in ROS-dependent ABA signaling in arabidopsis, 0, 2003
Kwak, JM; Mori, IC; Pei, Z-M; Leonhard, N; Torres, MA; Dangl, JL; Bloom, RE; Bodde, S; Jones, JDG; Schroeder, JI, EMBO Journal. 22 vol. (11); pp. 2623-2633

Research at channel level on the effect of LaCl<sub>3</sub> on Radish (Raphanus satirus L.) vacuolar membrane, 0, 2002
Shang, Y; Yang, P; Pei, Z, Chinese Science Bulletin. 47 vol. (2); pp. 111-115

Erratum: Abscisic acid activation of plasma membrane ca<sup>2+</sup> channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosph..., 0, 2002
Murata, Y; Pei, Z-M; Mori, IC; Schroeder, J, Plant Cell. 14 vol. (1); pp. 287-

Action Mechanism Research of Lanthanons to Slow Vacuolar Ion Channels in Raphanus Satirus L. (Xinlimei) Radish by Patch-Clamp, 0, 2001
Yang, P; Shang, YF; Pei, ZM, Chinese Chemical Letters. 12 vol. (9); pp. 813-814

Abscisic acid activation of plasma membrane Ca<sup>2+</sup> channels in guard cells requires cytosolic NAD(P)H and is differentially disrupted upstream and downstream of reactive oxygen species production in abi1-1 and abi2-1 protein phosphatase 2C ..., 0, 2001
Murata, Y; Pei, Z-M; Mori, IC; Schroeder, J, Plant Cell. 13 vol. (11); pp. 2513-2523

Calcium channels activated by hydrogen peroxide mediate abscisic acid signaling in guard cells, 2000
PEI, ZM, Nature. (2000) 406 pp. 731-734

Magnesium sensitizes slow vacuolar channels to physiological cytosolic calcium and inhibits fast vacuolar channels in fava bean guard cell vacuoles, 1999
Pei, Z-M; Ward, JM; Schroeder, JI, Plant Physiology. (1999) 121 vol. (3); pp. 977-986

Background ion channel activities in Arabidopsis guard cells and review of ion channel regulation by protein phosphorylation events, 1998
Pei, ZM; Schroeder, JI; Schwarz, M, Journal of Experimental Botany. (1998) 49 vol. (SPEC. ISS.); pp. 319-328

Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss, 1998
Pei, Z-M; Ghassemian, M; Kwak, CM; McCourt, P; Schroeder, JI, Science. (1998) 282 vol. (5387); pp. 287-290

A transient outward-rectifying K<sup>+</sup> channel current down-regulated by cytosolic Ca<sup>2+</sup> in Arabidopsis thaliana guard cells, 1998
Pei, Z-M; Baizabal-Aguirre, VM; Allen, GJ; Schroeder, JI, Proceedings of the National Academy of Sciences of USA. (1998) 95 vol. (11); pp. 6548-6553

Differential abscisic acid regulation of guard cell slow anion channels in arabidopsis wild-type and abi1 and abi2 mutants, 1997
Pei, Z-M; Kuchitsu, K; Ward, JM; Schwarz, M; Schroeder, JI, The Plant cell. (1997) 9 vol. (3); pp. 409-423

Expression of a Cs<sup>+</sup>-resistant guard cell K<sup>+</sup> channel confers Cs<sup>+</sup>-resistant, light-induced stomatal opening in transgenic Arabidopsis, October, 1997
Ichida, AM; Pei, Z-M; Baizabal-Aguirre, VM; Turner, KJ; Schroeder, JI, The Plant cell. (October, 1997) 9 vol. (10); pp. 1843-1857

Effect of salt stress on photosystem II heterogeneity in wheat leaves, 0, 1996
Pei, Z; Fu, W; Guo, L; Tang, Z, Science in China, Series C: Life Sciences. 39 vol. (5); pp. 501-510

A novel chloride channel in Vicia faba guard cell vacuoles activated by the serine/threonine kinase, CDPK, 1996
Pei, Z-M; Ward, JM; Harper, JF; Schroeder, JI, EMBO Journal. (1996) 15 vol. (23); pp. 6564-6574

Roles of ion channels in initiation of signal transduction in higher plants, 1995
Ward, JM; Pei, Z-M; Schroeder, JI, Plant Cell. (1995) 7 pp. 833-844

Book Chapters:

Calcium signals and their regulation in Intracellular Signalling in Plants, July 28, 2008
Pei ZM and Gilroy S