Zhen-Ming Pei

Associate Professor of Biology

Office: 
3102 Ffsc, Duke University, Durham, NC 27708-1000
Campus Box: 
Box 90338, Duke University, Durham, NC 27708-1000
Phone: 
(919) 613-8152
My laboratory is interested in the early signaling events by which plants sense environmental signals and decode to give the appropriate responses. Upon perception of external signals, cell surface receptors trigger an increase in cytosolic free calcium concentration, which is mediated by ion channels. Our long-term goals are to identify these receptors and ion channels, isolate their interacting components, and assign molecular functions to them. Currently, we are using multidisciplinary approaches of biophysics, biochemistry, cell biology, molecular genetics, and function genomics to dissect the signaling cascades of external calcium as well as nitric oxide in the model plant Arabidopsis.

Education

  • Ph.D., Shanghai Institute of Plant Physiology 1993

  • M.S., Fudan University (China) 1990

  • B.S., Lanzhou University (China) 1985

Cao, X-Q, Jiang, Z-H, Yi, Y-Y, Yang, Y, Ke, L-P, Pei, Z-M, and Zhu, S. "Biotic and Abiotic Stresses Activate Different Ca2+ Permeable Channels in Arabidopsis." Frontiers in plant science 8 (January 31, 2017): 83-. Full Text

Kong, D, Hu, H-C, Okuma, E, Lee, Y, Lee, HS, Munemasa, S, Cho, D, Ju, C, Pedoeim, L, Rodriguez, B, Wang, J, Im, W, Murata, Y, Pei, Z-M, and Kwak, JM. "L-Met Activates Arabidopsis GLR Ca(2+) Channels Upstream of ROS Production and Regulates Stomatal Movement." Cell reports 17, no. 10 (December 2016): 2553-2561. Full Text

Yuan, F, Yang, H, Xue, Y, Kong, D, Ye, R, Li, C, Zhang, J, Theprungsirikul, L, Shrift, T, Krichilsky, B, Johnson, DM, Swift, GB, He, Y, Siedow, JN, and Pei, ZM. "Corrigendum: OSCA1 mediates osmotic-stress-evoked Ca(2+) increases vital for osmosensing in Arabidopsis." Nature (February 2015).

Li, Y, Yuan, F, Wen, Z, Li, Y, Wang, F, Zhu, T, Zhuo, W, Jin, X, Wang, Y, Zhao, H, Pei, Z-M, and Han, S. "Genome-wide survey and expression analysis of the OSCA gene family in rice." BMC plant biology 15 (January 2015): 261-. Full Text

Yuan, F, Yang, H, Xue, Y, Kong, D, Ye, R, Li, C, Zhang, J, Theprungsirikul, L, Shrift, T, Krichilsky, B, Johnson, DM, Swift, GB, He, Y, Siedow, JN, and Pei, Z-M. "OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis." Nature 514, no. 7522 (October 2014): 367-371. Full Text

Hu, W-J, Chen, J, Liu, T-W, Wu, Q, Wang, W-H, Liu, X, Shen, Z-J, Simon, M, Chen, J, Wu, F-H, Pei, Z-M, and Zheng, H-L. "Proteome and calcium-related gene expression in Pinus massoniana needles in response to acid rain under different calcium levels." Plant and Soil 380, no. 1-2 (July 2014): 285-303. Full Text

Wu, X, Wu, F-H, Wang, X, Wang, L, Siedow, JN, Zhang, W, and Pei, Z-M. "Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING." Nucleic acids research 42, no. 13 (July 2014): 8243-8257. Full Text

Hu, WJ, Chen, J, Liu, TW, Wu, Q, Wang, WH, Liu, X, Shen, ZJ, Simon, M, Chen, J, Wu, FH, Pei, ZM, and Zheng, HL. "Proteome and calcium-related gene expression in Pinus massoniana needles in response to acid rain under different calcium levels." Plant and Soil 380, no. 1 (January 1, 2014): 285-303. Full Text

Liu, W-Z, Kong, D-D, Gu, X-X, Gao, H-B, Wang, J-Z, Xia, M, Gao, Q, Tian, L-L, Xu, Z-H, Bao, F, Hu, Y, Ye, N-S, Pei, Z-M, and He, Y-K. "Cytokinins can act as suppressors of nitric oxide in Arabidopsis." Proceedings of the National Academy of Sciences of the United States of America 110, no. 4 (2013): 1548-1553. Full Text

Pages

Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020

Plant Osmosensors awarded by National Science Foundation (Principal Investigator). 2015 to 2018

Multi-functional Plasmonics Nanoprobes for Cellular Sensing and Imaging awarded by Department of Energy (Co Investigator). 2015 to 2018

Functional analysis of Arabidopsis NSC1/DMI1 Ca2+ permeable channels awarded by National Science Foundation (Principal Investigator). 2009 to 2013

Molecular Genetic Analysis of Ca2+Channel-Mediated Cold Sensing awarded by Department of Agriculture (Principal Investigator). 2006 to 2009

Nutrient Ca2 Sensed by CAS Regulates the Floral Transition in Arabidopsis and Rice awarded by Department of Agriculture (Principal Investigator). 2005 to 2009

External-calcium Signal Transduction in Arabidopsis Guard Cells awarded by National Science Foundation (Principal Investigator). 2005 to 2008

Calcium Channel Regulation in Arabidopsis Guard Cells awarded by National Science Foundation (Principal Investigator). 2002 to 2005