Xinnian Dong

Arts and Sciences Professor of Biology in the Trinity College of Arts and Sciences

Office: 
4213 French Family Science Center, Durham, NC 27708
Campus Box: 
Box 90338, Durham, NC 27708-1000
Phone: 
(919) 613-8176
Using Arabidopsis thaliana as a model system, my laboratory studies the mechanisms of plant defense against microbial pathogens. We focus on a specific response known as systemic acquired resistance (SAR). SAR, which can be induced by a local infection, provides the plants with long lasting, systemic resistance against a broad spectrum of pathogens. Salicylic acid (SA; an active ingredient of aspirin) has been found to be the endogenous signal of SAR. Using a genetic approach, our laboratory identified genes involved in the regulation of SAR. Molecular and genetic analyses are being carried out to understand the gene function and to elucidate the SAR signaling pathway. These SAR-regulating genes are also favorite targets for molecular engineering of disease-resistance crops.

Education

  • Ph.D., Northwestern University 1988

  • B.S., National Wuhan University 1982

Mammarella, ND, Cheng, Z, Fu, ZQ, Daudi, A, Bolwell, GP, Dong, X, and Ausubel, FM. "Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae." Phytochemistry 112, no. 1 (2015): 110-121. Full Text

Wang, S, Gu, Y, Zebell, SG, Anderson, LK, Wang, W, Mohan, R, and Dong, X. "A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity." Cell Host & Microbe 16, no. 6 (December 2014): 787-794. Full Text

Yan, S, and Dong, X. "Perception of the plant immune signal salicylic acid." Current Opinion in Plant Biology 20 (August 2014): 64-68. (Review) Full Text

Yan, S, Wang, W, Marqués, J, Mohan, R, Saleh, A, Durrant, WE, Song, J, and Dong, X. "Salicylic acid activates DNA damage responses to potentiate plant immunity." Molecular Cell 52, no. 4 (November 21, 2013): 602-610. Full Text

Fu, ZQ, and Dong, X. "Systemic acquired resistance: turning local infection into global defense." Annual Review of Plant Biology 64 (January 25, 2013): 839-863. (Review) Full Text

Chen, X, Barnaby, JY, Sreedharan, A, Huang, X, Orbović, V, Grosser, JW, Wang, N, Dong, X, and Song, W-Y. "Over-expression of the citrus gene CtNH1 confers resistance to bacterial canker disease." Physiological and Molecular Plant Pathology 84, no. 1 (2013): 115-122. Full Text

Yan, S, Wang, W, Marqués, J, Mohan, R, Saleh, A, Durrant, W, Song, J, and Dong, X. "Salicylic Acid Activates DNA Damage Responses to Potentiate Plant Immunity." Molecular Cell (2013).

Zheng, X-Y, Spivey, NW, Zeng, W, Liu, P-P, Fu, ZQ, Klessig, DF, He, SY, and Dong, X. "Coronatine promotes Pseudomonas syringae virulence in plants by activating a signaling cascade that inhibits salicylic acid accumulation." Cell Host & Microbe 11, no. 6 (June 2012): 587-596. Full Text

Fu, ZQ, Yan, S, Saleh, A, Wang, W, Ruble, J, Oka, N, Mohan, R, Spoel, SH, Tada, Y, Zheng, N, and Dong, X. "NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants." Nature 486, no. 7402 (May 16, 2012): 228-232. Full Text

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Selected Grants

Function of NPR1 in Plant Disease Resistance awarded by National Institutes of Health (Principal Investigator). 1998 to 2000

(97-0776) Molecular and Genetic Studies of Mutants Insensitive to SAR-inducing Signals awarded by Department of Agriculture (Principal Investigator). 1995 to 1998

(96-0762) Molecular and Genetic Studies of Mutants Insensitive to SAR-inducing Signals awarded by Department of Agriculture (Principal Investigator). 1995 to 1997

(95-0298) Molecular and Genetic Studies of Mutants Insensitive to SAR-inducing Signals awarded by Department of Agriculture (Principal Investigator). 1995 to 1996

(93-0420) Molecular Genetic Analysis of Systemic Acquired Resistance in A. thaliana awarded by Cooperative State Research Service (CSRS) (Principal Investigator). 1993 to 1995

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