Xinnian Dong

Arts and Sciences Professor of Biology in the Trinity College of Arts and Sciences

Office: 
4213 French Family Science Center, Durham, NC 27708
Campus Box: 
Box 90338, Durham, NC 27708-1000
Phone: 
(919) 613-8176
Using Arabidopsis thaliana as a model system, my laboratory studies the mechanisms of plant defense against microbial pathogens. We focus on a specific response known as systemic acquired resistance (SAR). SAR, which can be induced by a local infection, provides the plants with long lasting, systemic resistance against a broad spectrum of pathogens. Salicylic acid (SA; an active ingredient of aspirin) has been found to be the endogenous signal of SAR. Using a genetic approach, our laboratory identified genes involved in the regulation of SAR. Molecular and genetic analyses are being carried out to understand the gene function and to elucidate the SAR signaling pathway. These SAR-regulating genes are also favorite targets for molecular engineering of disease-resistance crops.

Education

  • Ph.D., Northwestern University 1988

  • B.S., National Wuhan University 1982

Zebell, SG, and Dong, X. "Cell-Cycle Regulators and Cell Death in Immunity." Cell host & microbe 18, no. 4 (October 2015): 402-407. (Review) Full Text

Yang, L, Li, B, Zheng, X-Y, Li, J, Yang, M, Dong, X, He, G, An, C, and Deng, XW. "Corrigendum: Salicylic acid biosynthesis is enhanced and contributes to increased biotrophic pathogen resistance in Arabidopsis hybrids." Nature Communications 6 (August 12, 2015): 8145-8145. Full Text

Saleh, A, Withers, J, Mohan, R, Marqués, J, Gu, Y, Yan, S, Zavaliev, R, Nomoto, M, Tada, Y, and Dong, X. "Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses." Cell host & microbe 18, no. 2 (August 2015): 169-182. Full Text

Zheng, X-Y, Zhou, M, Yoo, H, Pruneda-Paz, JL, Spivey, NW, Kay, SA, and Dong, X. "Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid." Proceedings of the National Academy of Sciences of the United States of America 112, no. 30 (July 2, 2015): 9166-9173. Full Text

Zhou, M, Wang, W, Karapetyan, S, Mwimba, M, Marqués, J, Buchler, NE, and Dong, X. "Redox rhythm reinforces the circadian clock to gate immune response." Nature 523, no. 7561 (July 2015): 472-476. Full Text Open Access Copy

Gu, Y, and Dong, X. "Stromules: Signal Conduits for Plant Immunity." Developmental cell 34, no. 1 (July 2015): 3-4. Full Text

Yang, L, Li, B, Zheng, X-Y, Li, J, Yang, M, Dong, X, He, G, An, C, and Deng, XW. "Salicylic acid biosynthesis is enhanced and contributes to increased biotrophic pathogen resistance in Arabidopsis hybrids." Nature Communications 6 (June 12, 2015): 7309-. Full Text Open Access Copy

Mammarella, ND, Cheng, Z, Fu, ZQ, Daudi, A, Bolwell, GP, Dong, X, and Ausubel, FM. "Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae." Phytochemistry 112 (April 2015): 110-121. Full Text

Mammarella, ND, Cheng, Z, Fu, ZQ, Daudi, A, Bolwell, GP, Dong, X, and Ausubel, FM. "Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae." Phytochemistry 112, no. 1 (2015): 110-121. Full Text

Wang, S, Gu, Y, Zebell, SG, Anderson, LK, Wang, W, Mohan, R, and Dong, X. "A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity." Cell host & microbe 16, no. 6 (December 2014): 787-794. Full Text

Pages

Intercellular signal transport in plant immune response awarded by US-Israel Binational Agricultural R&D Fund (Principal Investigator). 2014 to 2016

Arabidopsis 2010: Global Analysis of Plant Disease Resistance Pathways awarded by National Science Foundation (Principal Investigator). 2001 to 2015

The 22nd International Conference on Arabidopsis Research awarded by National Science Foundation (Principal Investigator). 2011 to 2012

The Arabidopsis SNI1 complex regulate both gene transcription an awarded by National Science Foundation (Principal Investigator). 2008 to 2012

A Systems Approach to Broad-Spectrum Disease Resistance Using NPR1-Mediated Gene Expression awarded by Department of Agriculture (Principal Investigator). 2007 to 2010

Chromosome Modification and Transcription Repression in Regulation of Systemic Acquired Resistance awarded by National Science Foundation (Principal Investigator). 2005 to 2009

Characterization of the direct-target genes of NPR1 in systemic acquired resistance awarded by Department of Agriculture (Principal Investigator). 2003 to 2007

Characterization of Negative Regulators of NPR1-Mediated Systemic Acquired Resistance awarded by National Science Foundation (Principal Investigator). 1998 to 2006

Identification of Signaling Components in NPR1-independent Resistance awarded by Department of Agriculture (Principal Investigator). 2000 to 2004

(98-0421) Further Dissection of Signalling Pathways Leading To Disease Resistance awarded by Cooperative State Research Service (CSRS) (Principal Investigator). 1998 to 2001

Pages