Steven B. Haase

Associate Professor of Biology

Office: 
4316 French, Durham, NC 27708
Campus Box: 
Box 90338, Durham, NC 27708-1000
Phone: 
(919) 613-8205
Our group is broadly interested in understanding the biological clock mechanisms that control the timing of events during the cell division cycle. In 2008, the Haase group proposed a new model in which a complex network of sequentially activated transcription factors regulates the precise timing of gene expression during the cell-cycle, and functions as a robust time-keeping oscillator. Greater than a thousand genes are expressed at distinct phases of the cycle, and the control network itself consists of ~20 components, so this dynamical system is far too complex to understand simply by biological intuition. We rely heavily on the expertise of the Harer group (Dept. of Mathematics, Duke University) for the analysis of complex data, and their understanding of dynamical systems.  Using a collection of tools, including molecular genetics, genomics, mathematical models, and statistical inference, our groups aim to understand how the cell division clock works, how it might be perturbed in proliferative diseases such as cancer, and how the clock components might be targeted for new anti-tumor therapies.  Qualitatively, the clock networks that control the yeast cell cycle look much like the networks controlling circadian rhythms in a variety of organisms. More recently, we have been using our experimental and quantitative approaches to investigate the function of circadian clocks, as well as clocks that control the division and development of pathogenic organisms such as P. falciparum and P. vivax, the causative agents of malaria.

Education

  • Ph.D., Stanford University 1993

  • B.S., Colorado State University at Fort Collins 1985

Bristow, SL, Leman, AR, and Haase, SB. Cell cycle-regulated transcription: Effectively using a genomics toolbox. January 1, 2014. Full Text

Bristow, SL, Leman, AR, and Haase, SB. Cell cycle-regulated transcription: Effectively using a genomics toolbox. Humana Press Inc., 2014. Full Text

Kelliher, CM, Leman, AR, Sierra, CS, and Haase, SB. "Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans." PLoS genetics 12, no. 12 (December 5, 2016): e1006453-. Full Text

McGoff, KA, Guo, X, Deckard, A, Kelliher, CM, Leman, AR, Francey, LJ, Hogenesch, JB, Haase, SB, and Harer, JL. "The Local Edge Machine: inference of dynamic models of gene regulation." Genome biology 17, no. 1 (October 19, 2016): 214-.

Perea, JA, Deckard, A, Haase, SB, and Harer, J. "SW1PerS: Sliding windows and 1-persistence scoring; discovering periodicity in gene expression time series data." BMC bioinformatics 16 (August 16, 2015): 257-. Full Text

Bristow, SL, Leman, AR, Simmons Kovacs, LA, Deckard, A, Harer, J, and Haase, SB. "Checkpoints couple transcription network oscillator dynamics to cell-cycle progression." Genome biology 15, no. 9 (September 5, 2014): 446-. Full Text

Leman, AR, Bristow, SL, and Haase, SB. "Analyzing transcription dynamics during the budding yeast cell cycle." Methods in Molecular Biology 1170 (January 1, 2014): 295-312. Full Text

Haase, SB, and Wittenberg, C. "Topology and control of the cell-cycle-regulated transcriptional circuitry." Genetics 196, no. 1 (January 2014): 65-90. (Review) Full Text

Bristow, SL, Leman, AR, and Haase, SB. "Cell cycle-regulated transcription: effectively using a genomics toolbox." Methods in molecular biology (Clifton, N.J.) 1170 (January 2014): 3-27. Full Text

Leman, AR, Bristow, SL, and Haase, SB. "Analyzing transcription dynamics during the budding yeast cell cycle." Methods in molecular biology (Clifton, N.J.) 1170 (January 2014): 295-312. Full Text

Leman, AR, Bristow, SL, and Haase, SB. "Analyzing transcription dynamics during the budding yeast cell cycle." Methods in Molecular Biology 1170 (2014): 295-312. Full Text

Pages

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020

Molecular Mycology and Pathogenesis Training Program awarded by National Institutes of Health (Mentor). 2015 to 2019

Impact of Sickle-Trait on Transcriptional Regulation in P. Falciparum Parasites awarded by National Institutes of Health (Co Investigator). 2017 to 2018

Cyclin/Cdk and Kinesin-5 Control of Spindle Assembly in Budding Yeast awarded by National Science Foundation (Principal Investigator). 2007 to 2011