Paul Mitaari Magwene

Associate Professor of Biology

124 Science Drive, Room 4103 Ffsc, Duke Box 90338, Durham, NC 27708
Campus Box: 
(919) 613-8159

Lab Site:


  • Ph.D. 1999, University of Chicago

  • AB 1993, Harvard College

Papers Published

The quick and the dead: microbial demography at the yeast thermal limit., 3, 2017
Maxwell, CS; Magwene, PM, Molecular Ecology. 26 vol. (6); pp. 1631-1640

When sensing is gambling: An experimental system reveals how plasticity can generate tunable bet-hedging strategies., 2, 2017
Maxwell, CS; Magwene, PM, Evolution.

The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen., 5, 2015
Strope, PK; Skelly, DA; Kozmin, SG; Mahadevan, G; Stone, EA; Magwene, PM; Dietrich, FS; McCusker, JH, Genome research. 25 vol. (5); pp. 762-774

2μ plasmid in Saccharomyces species and in Saccharomyces cerevisiae., 12, 2015
Strope, PK; Kozmin, SG; Skelly, DA; Magwene, PM; Dietrich, FS; McCusker, JH, Fems Yeast Research. 15 vol. (8);

Revisiting mortimer's genome renewal hypothesis: Heterozygosity, homothallism, and the potential for adaptation in yeast, 1, 2014
Magwene, PM, Adv Exp Med Biol. 781 pp. 37-48

Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway., May, 2013
K Gonzales, O Kayıkçı, DG Schaeffer, PM Magwene, BMC Syst Biol. (May, 2013) 7 pp. 40

The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae., 2013
Granek, JA; Murray, D; Kayrkçi, Ö; Magwene, PM, Genetics. (2013) 193 vol. (2); pp. 587-600

Biomechanics of turtle shells: how whole shells fail in compression., 2013
Magwene, PM; Socha, JJ, J Exp Zool A Ecol Genet Physiol. (2013) 319 vol. (2); pp. 86-98

Natural variation in CDC28 underlies morphological phenotypes in an environmental yeast isolate., 7, 2011
Lee, HN; Magwene, PM; Brem, RB, Genetics. 188 vol. (3); pp. 723-730

Outcrossing, mitotic recombination, and life-history trade-offs shape genome evolution in Saccharomyces cerevisiae., 2, 2011
Magwene, PM; Kayıkçı, Ö; Granek, JA; Reininga, JM; Scholl, Z; Murray, D, Proceedings of the National Academy of Sciences of USA. 108 vol. (5); pp. 1987-1992

Pleiotropic signaling pathways orchestrate yeast development., 12, 2011
Granek, JA; Kayıkçı, Ö; Magwene, PM, Current Opinion in Microbiology. 14 vol. (6); pp. 676-681

The statistics of bulk segregant analysis using next generation sequencing., 11, 2011
Magwene, PM; Willis, JH; Kelly, JK, PLoS computational biology. 7 vol. (11); pp. e1002255

Modeling mutant phenotypes and oscillatory dynamics in the \emph{Saccharomyces cerevisiae} cAMP-PKA pathway, 12, 2010
Gonzales, K; Kayikci, O; Schaeffer, DG; Magwene, P, PLoS Computational Biology.

Environmental and genetic determinants of colony morphology in yeast., 1, 2010
Granek, JA; Magwene, PM, PLoS genetics. 6 vol. (1); pp. e1000823

Statistical methods for studying modularity: a reply to Mitteroecker and Bookstein., 2009
Magwene, PM, Systematic Biology (OUP). (2009) 58 vol. (1); pp. 146-149

Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal., 11, 2009
Munger, SC; Aylor, DL; Syed, HA; Magwene, PM; Threadgill, DW; Capel, B, Genes & development. 23 vol. (21); pp. 2521-2536

Using correlation proximity graphs to study phenotypic integration, 0, 2008
Magwene, PM, Evolutionary Biology. 35 vol. (3); pp. 191-198

Integration and modularity in biological systems: A review, 2006
Magwene, PM, Acta Zoologica Sinica. (2006) 52 pp. 490-493

Estimating genomic coexpression networks using first-order conditional independence., 0, 2004
Magwene, PM; Kim, J, Genome Biology. 5 vol. (12); pp. R100

Computational challenges for integrative genomics, 0, 2004
Kim, J; Magwene, PM, Genomics and Informatics. 2 vol. (1); pp. 7-18

Reconstructing the temporal ordering of biological samples using microarray data., 2003
Magwene, PM; Lizardi, P; Kim, J, Bioinformatics. (2003) 19 vol. (7); pp. 842-850

The naturalist in a world of genomics, 2003
Stearns, SC; Magwene, P, American Naturalist. (2003) 161 vol. (2); pp. 171-180

Comparing ontogenetic trajectories using growth process data., 2001
Magwene, PM, Systematic Biology (OUP). (2001) 50 vol. (5); pp. 640-656

New tools for studying integration and modularity., 2001
Magwene, PM, Evolution. (2001) 55 vol. (9); pp. 1734-1745

Morphological Integration: Forty Years Later, 1999
B. Chernoff and P. M. Magwene, (1999)

Predatory Dinosaurs from the Sahara and Late Cretaceous Faunal Differentiation, 5, 1996
Sereno, PC; Dutheil, DB; Iarochene, M; Larsson, HCE; Lyon, GH; Magwene, PM; Sidor, CA; Varricchio, DJ; Wilson, JA, Science. 272 vol. (5264); pp. 986-991

Predatory dinosaurs from the Sahara and late Cretaceious faunal differntiation, 1996
Sereno, PC; Dutheil, DB; Iarochene, M; Larsson, H; Lyon, G; Magwene, P; Sidor, C; Varricchio, D; Wilson, J, Science. (1996) 272 vol. (17); pp. 986-991


  • 1998 Ford Foundation Fellowships/ Dissertaton, National Academies, The