Nicholas W. Gillham

James B. Duke Professor Emeritus of Zoology

Office: 
038 Bio Sci, Durham, NC 27708
Campus Box: 
Box 0338, Durham, NC 27708-1000
Phone: 
(919) 613-8160
The objective of my collaborative research with Dr. John Boynton in the Department of Botany is to understand how nuclear and organelle genomes interact in controlling the biogenesis of chloroplasts and mitochondria. For many years we have used the unicellular green alga Chlamydomonas reinhardtii as a model experimental system. This alga has well developed chloroplast genetics. Mutations affecting either chloroplast or mitochondrial functions are viable under appropriate growth conditions. Our recent success in transforming the chloroplast genome of Chlamydomonas now allows us to determine the consequences in vivo of manipulating the chloroplast genes in vitro. Ongoing projects in our laboratory presently include: 1.Mutational analysis of the chloroplast psbA gene encoding the D-1 reaction center protein of photosystem II to examine the relationship between photoinhibition and photosynthetic performance. 2.Characterization of the interaction of proteins and rRNA domains of the small subunit of the chloroplast ribosome involved in translational efficiency and fidelity. 3.Translational regulation of chloroplast genes encoding photosynthetic and ribosomal proteins. 4.Molecular analysis of chloroplast recombination. 5.Genetic dissection of mechanisms responsible for the inheritance of chloroplast and mitochondrial genomes from opposite parents in crosses.

Education

  • Ph.D., Harvard University 1962

  • M.A., Harvard University 1955

  • B.A., Harvard University 1954

Gillham, NW. "Sir Francis Galton and the birth of eugenics." Annual review of genetics 35 (January 2001): 83-101. Full Text

(98-0861) The Chlamydomonas Genetics Center awarded by National Science Foundation (Co-Principal Investigator). 1994 to 2000

(97-0452) Molecular, Genetic, and Physiological Analysis of Photoinhibition and Photosynthetic Performance awarded by Department of Energy (Co-Principal Investigator). 1989 to 2000

(95-0655) Hereditary Control of Organelle Structure and Function awarded by National Institutes of Health (Co-Principal Investigator). 1975 to 1999

(95-0770) The Chlamydomonas Genetics Center awarded by National Science Foundation (Co-Principal Investigator). 1994 to 1999

(96-0390) Molecular, Genetic and Physiological Analysis of Photoinhibition and Photosynthetic Performance awarded by Office of Energy Research (Co-Principal Investigator). 1989 to 1999

(94-0024) The Chlamydomonas Genetics Center awarded by National Science Foundation (Co-Principal Investigator). 1994 to 1998

(97-0827) The Chlamydomonas Genetics Center awarded by National Science Foundation (Co-Principal Investigator). 1994 to 1998

(95-0065) Molecular, Genetic and Physiological Analysis of Photoinhibition and Photosynthetic Performance awarded by Department of Energy (Co-Principal Investigator). 1989 to 1998

(96-0766) The Chlamydomonas Genetics Center awarded by National Science Foundation (Co-Principal Investigator). 1994 to 1997

(94-1025) Hereditary Control of Organelle Structure and Function awarded by National Institutes of Health (Co-Principal Investigator). 1975 to 1996

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