Marcy K. Uyenoyama

Professor of Biology

Office: 
130 Science Drive, Room 137, Duke Box 90338, Durham, NC 27708
Campus Box: 
90338
Phone: 
(919) 660-7350
Fax: 
(919) 660-7293

Lab Site: http://www.biology.duke.edu/marcylab/

Research Interests: 

Marcy Uyenoyama studies mechanisms of evolutionary change at the molecular and population levels. Among the questions under study include the prediction and detection of the effects of natural selection on genomic structure. A major area of research addresses the development of maximum-likelihood and Bayesian methods for inferring evolutionary processes from the pattern of molecular variation. Evolutionary processes currently under study include characterization of population structure across genomes.

Marcy Uyenoyama studies mechanisms of evolutionary change at the molecular and population levels. Among the questions under study include the prediction and detection of the effects of natural selection on genomic structure. A major area of research addresses the development of maximum-likelihood and Bayesian methods for inferring evolutionary processes from the pattern of molecular variation. Evolutionary processes currently under study include characterization of population structure across genomes.

Education

  • National Science Foundation National Needs Fellow 1978, Harvard University

  • Biological Sciences, PhD, 1978, Stanford University

  • Ph.D. 1978, Stanford University

  • Mathematics, BS 1974, Stanford University

  • B.S. 1974, Stanford University

Papers Published

Genealogical histories in structured populations., 6, 2015
Kumagai, S; Uyenoyama, MK, Theoretical Population Biology. 102 pp. 3-15

Editor's Report for Volume 28 (2011)., 1, 2013
Uyenoyama, MK, Molecular Biology and Evolution. 30 vol. (1); pp. 236-237

Editor's report for volume 27 (2010), 0, 2012
Uyenoyama, MK, Molecular Biology and Evolution. 29 vol. (5); pp. 1493-1494

SMBE proposal to the government of Japan, January, 2012
Wolfe, K; Wayne, ML; Makova, K; Steen, TY; Uyenoyama, M; Takahata, N, Molecular Biology and Evolution. (January, 2012) 29 vol. (1); pp. 441-

Effects of polymorphism for locally adapted genes on rates of neutral introgression in structured populations., 2011
Fusco, D; Uyenoyama, MK, Theor Popul Biol. (2011) 80 vol. (2); pp. 121-131

Sex-specific incompatibility generates locus-specific rates of introgression between species., 2011
Fusco, D; Uyenoyama, MK, Genetics. (2011) 189 vol. (1); pp. 267-288

Editorial: MBE Editor's Report, 0, 2010
Uyenoyama, MK, Molecular Biology and Evolution. 27 vol. (3); pp. 742-743

Molecular Biology and Evolution: Editor's report, 0, 2010
Uyenoyama, MK, Molecular Biology and Evolution. 27 vol. (12); pp. 2890-2891

Ancestral population genomics: the coalescent hidden Markov model approach., 9, 2009
Dutheil, JY; Ganapathy, G; Hobolth, A; Mailund, T; Uyenoyama, MK; Schierup, MH, Genetics. 183 vol. (1); pp. 259-274

Site frequency spectra from genomic SNP surveys., 6, 2009
Ganapathy, G; Uyenoyama, MK, Theoretical Population Biology. 75 vol. (4); pp. 346-354

Importance sampling for the infinite sites model., 0, 2008
Hobolth, A; Uyenoyama, MK; Wiuf, C, Statistical Applications in Genetics and Molecular Biology. 7 vol. (1); pp. Article32

Importance sampling for the infinite sites model., 0, 2008
A Hobolth, MK Uyenoyama, C Wiuf, Stat Appl Genet Mol Biol. 7 vol. (1); pp. Article32

Importance sampling for the infinite sites model., 0, 2008
A Hobolth, MK Uyenoyama, C Wiuf, Stat Appl Genet Mol Biol. 7 vol. (1); pp. Article32

The evolutionary forest algorithm., 8, 2007
Leman, SC; Uyenoyama, MK; Lavine, M; Chen, Y, Bioinformatics. 23 vol. (15); pp. 1962-1968

The evolutionary dynamics of self-incompatibility systems., 9, 2005
Newbigin, E; Uyenoyama, MK, Trends in Genetics. 21 vol. (9); pp. 500-505

Likelihoods from summary statistics: recent divergence between species., 2005
Leman, SC; Chen, Y; Stajich, JE; Noor, MAF; Uyenoyama, MK, Genetics. (2005) 171 vol. (3); pp. 1419-1436

Evolution under tight linkage to mating type., 2005
Uyenoyama, MK, New Phytologist. (2005) 165 vol. (1); pp. 63-70

Likelihoods from summary statistics: Recent divergence between species, 0, 2005
S. C. Leman, and Y. Chen, and J. E. Stajich, and M. A. F. Noor, and M.K. Uyenoyama, Genetics. 171 pp. 1419-1436

On the evolutionary costs of self-incompatibility: incomplete reproductive compensation due to pollen limitation., 2004
Vallejo-Marín, M; Uyenoyama, MK, Evolution. (2004) 58 vol. (9); pp. 1924-1935

Maximum-likelihood estimation of rates of recombination within mating-type regions., 2004
Takebayashi, N; Newbigin, E; Uyenoyama, MK, Genetics. (2004) 167 vol. (4); pp. 2097-2109

A simple method for computing exact probabilities of mutation numbers., 5, 2004
Uyenoyama, MK; Takebayashi, N, Theoretical Population Biology. 65 vol. (3); pp. 271-284

Genus-specific diversification of mating types, 2004
M.K. Uyenoyama and N. Takebayashi, (2004) pp. 254-271

Genealogy-dependent variation in viability among self-incompatibility genotypes., 6, 2003
Uyenoyama, MK, Theoretical Population Biology. 63 vol. (4); pp. 281-293

Patterns of variation within self-incompatibility loci., 11, 2003
Takebayashi, N; Brewer, PB; Newbigin, E; Uyenoyama, MK, Molecular Biology and Evolution. 20 vol. (11); pp. 1778-1794

On the origin of self-incompatibility haplotypes: transition through self-compatible intermediates., 4, 2001
Uyenoyama, MK; Zhang, Y; Newbigin, E, Genetics. 157 vol. (4); pp. 1805-1817

Outbreeding, 0, 2001
M.K. Uyenoyama,

Evolutionary dynamics of self-incompatibility alleles in Brassica., 9, 2000
Uyenoyama, MK, Genetics. 156 vol. (1); pp. 351-359

Evolutionary dynamics of dual-specificity self-incompatibility alleles., 3, 2000
Uyenoyama, MK; Newbigin, E, The Plant cell. 12 vol. (3); pp. 310-312

Mutational origin of new mating type specificities in flowering plants., 12, 2000
Uyenoyama, MK, Genes & genetic systems. 75 vol. (6); pp. 305-311

The evolution of breeding systems, 0, 2000
M.K. Uyenoyama,

Evolutionary dynamics of self-incompatibility systems in flowering plants, 0, 2000
Uyenoyama, MK, J. Reprod. Dev.. 46 pp. 35-36

A prospectus for new developments in the evolutionary theory of self-incompatibility, 0, 2000
Uyenoyama, MK, Annals of Botany (Elsevier). 85 vol. (SUPPL. A); pp. 247-252

Genealogical structure among alleles regulating self-incompatibility in natural populations of flowering plants., 1997
Uyenoyama, MK, Genetics. (1997) 147 vol. (3); pp. 1389-1400

Allelic diversity and gene genealogy at the self-incompatibility locus in the Solanaceae., 1996
Richman, AD; Uyenoyama, MK; Kohn, JR, Science. (1996) 273 vol. (5279); pp. 1212-1216

S-allele diversity in a natural population of Physalis crassifolia (Solanaceae) (ground cherry) assessed by RT-PCR., 5, 1996
Richman, AD; Uyenoyama, MK; Kohn, JR, Heredity. 76 ( Pt 5) pp. 497-505

S-allele diversity in a natural population of Physalis crassifolia (Solanaceae) (ground cherry) assessed by RT-PCR., 1996
Richman, AD; Uyenoyama, MK; Kohn, JR, Heredity. (1996) 76 pp. Pt 5/-

A generalized least-squares estimate for the origin of sporophytic self-incompatibility., 1995
Uyenoyama, MK, Genetics. (1995) 139 vol. (2); pp. 975-992

S-allele sequence diversity in natural populations of Solanum carolinense (Horsenettle)., 10, 1995
Richman, AD; Kao, TH; Schaeffer, SW; Uyenoyama, MK, Heredity. 75 ( Pt 4) pp. 405-415

Frequency-dependent disease transmission and the dynamics of the Silene-ustilago host-pathogen system, 1995
Thrall, PH; Biere, A; Uyenoyama, MK, American Naturalist. (1995) 145 vol. (1); pp. 43-62

Coevolution of self-fertilization and inbreeding depression. II. Symmetric overdominance in viability., 1991
Uyenoyama, MK; Waller, DM, Theoretical Population Biology. (1991) 40 vol. (1); pp. 47-77

Coevolution of self-fertilization and inbreeding depression. I. Mutation-selection balance at one and two loci., 1991
Uyenoyama, MK; Waller, DM, Theoretical Population Biology. (1991) 40 vol. (1); pp. 14-46

On the evolution of genetic incompatibility systems. VI. A three-locus modifier model for the origin of gametophytic self-incompatibility., 1991
Uyenoyama, MK, Genetics. (1991) 128 vol. (2); pp. 453-469

Coevolution of self-fertilization and inbreeding depression. III. Homozygous lethal mutations at multiple loci., 1991
Uyenoyama, MK; Waller, DM, Theoretical Population Biology. (1991) 40 vol. (2); pp. 173-210

Evolution of the segregation ratio: modification of gene conversion and meiotic drive., 1990
Bengtsson, BO; Uyenoyama, MK, Theoretical Population Biology. (1990) 38 vol. (2); pp. 192-218

On the evolution of genetic incompatibility systems. V. Origin of sporophytic self-incompatibility in response to overdominance in viability., 1989
Uyenoyama, MK, Theoretical Population Biology. (1989) 36 vol. (3); pp. 339-365

On the origin of meiotic reproduction: a genetic modifier model., 1989
Uyenoyama, MK; Bengtsson, BO, Genetics. (1989) 123 vol. (4); pp. 873-885

Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations., 1989
Uyenoyama, MK, Genetics. (1989) 121 vol. (1); pp. 139-151

Coevolution of the major histocompatibility complex and the t-complex in the mouse. II. Modification of response to sharing of histocompatibility antigens., 1989
Uyenoyama, MK, Genetics. (1989) 121 vol. (1); pp. 153-161

On the evolution of genetic incompatibility systems. III. Introduction of weak gametophytic self-incompatibility under partial inbreeding., 1988
Uyenoyama, MK, Theoretical Population Biology. (1988) 34 vol. (1); pp. 47-91

On the evolution of genetic incompatibility systems. IV. Modification of response to an existing antigen polymorphism under partial selfing., 1988
Uyenoyama, MK, Theoretical Population Biology. (1988) 34 vol. (3); pp. 347-377

On the evolution of genetic incompatibility systems. II. Initial increase of strong gametophytic self-incompatibility under partial selfing and half-sib mating, 1988
Uyenoyama, MK, American Naturalist. (1988) 131 vol. (5); pp. 700-722

Inbreeding and the cost of meiosis: the evolution of selfing in populations practising biparental inbreeding., 1986
Uyenoyama, MK, Evolution. (1986) 40 vol. (2); pp. 388-404

Quantitative models of hybrid dysgenesis: rapid evolution under transposition, extrachromosomal inheritance, and fertility selection., 1985
Uyenoyama, MK, Theoretical Population Biology. (1985) 27 vol. (2); pp. 176-201

On the evolution of parthenogenesis. II. Inbreeding and the cost of meiosis., 1985
Uyenoyama, MK, Evolution. (1985) 39 vol. (6); pp. 1194-1206

INBREEDING AND THE EVOLUTION OF ALTRUISM UNDER KIN SELECTION - EFFECTS ON RELATEDNESS AND GROUP-STRUCTURE, 1984
UYENOYAMA, MK, Evolution. (1984) 38 vol. (4); pp. 778-795

ON THE EVOLUTION OF PARTHENOGENESIS - A GENETIC REPRESENTATION OF THE COST OF MEIOSIS, 1984
UYENOYAMA, MK, Evolution. (1984) 38 vol. (1); pp. 87-102

Towards a genetic theory for the evolution of the sex ratio. III. Parental and sibling control of brood investment ratio under partial sib-mating., 1982
Uyenoyama, MK; Bengtsson, BO, Theoretical Population Biology. (1982) 22 vol. (1); pp. 43-68

THE GENETICS OF ALTRUISM - BOORMAN,SA, LEVITT,PR, 0, 1982
UYENOYAMA, MK, Ethology and Sociobiology. 3 vol. (1); pp. 47-48

Population genetic theory of kin selection. II. The multiplicative model., 1982
Uyenoyama, MK; Feldman, M, American Naturalist. (1982) 120 vol. (5); pp. 614-627

Population genetic theory of kin selection: Multiple alleles at one locus., 8, 1981
Uyenoyama, MK; Feldman, MW; Mueller, LD, Proceedings of the National Academy of Sciences of USA. 78 vol. (8); pp. 5036-5040

On relatedness and adaptive topography in kin selection, 1981
Uyenoyama, MK; Feldman, MW, Theoretical Population Biology. (1981) 19 vol. (1); pp. 87-123

Towards a genetic theory for the evolution of the sex ratio II. Haplodiploid and diploid models with sibling and parental control of the brood sex ratio and brood size, 1981
Uyenoyama, MK; Bengtsson, BO, Theoretical Population Biology. (1981) 20 vol. (1); pp. 57-79

Population genetic theory of kin selection: Multiple alleles at one locus, 1981
Uyenoyama, MK; Feldman, MW; Mueller, LD, Proceedings of the National Academy of Sciences of the United States of America. (1981) 78 vol. (8 I); pp. 5036-5040

Theories of kin and group selection: A population genetics perspective, 1980
Uyenoyama, M; Feldman, MW, Theoretical Population Biology. (1980) 17 vol. (3); pp. 380-414

Towards a genetic theory for the evolution of the sex ratio., 1979
Uyenoyama, MK; Bengtsson, BO, Genetics. (1979) 93 vol. (3); pp. 721-736

Evolution of altruism under group selection in large and small populations in fluctuating environments, 1979
Uyenoyama, MK, Theoretical Population Biology. (1979) 15 vol. (1); pp. 58-85

Evolutionary effects of contagious and familial transmission, 1979
Uyenoyama, M; Feldman, MW; Cavalli-Sforza, LL, Proceedings of the National Academy of Sciences of the United States of America. (1979) 76 vol. (1); pp. 420-424

The genetics of sex ratio distortion by cytoplasmic infection under maternal and contagious transmission: an epidemiological study., 1978
Uyenoyama, MK; Feldman, MW, Theoretical Population Biology. (1978) 14 vol. (3); pp. 471-497

Book Chapters:

Heterogeneity in neutral divergence across genomic regions induced by sex-specific hybrid incompatibility in Evolution in the fast lane: Rapidly evolving genes and genetic systems, 2012
Seiji Kumagai and Marcy K. Uyenoyama

On the evolutionary modification of self-incompatibility: Implications of partial clonality for allelic diversity and genealogical structure in Self-Incompatibility in Flowering Plants: Evolution, Diversity, and Mechanisms, 2008
Vallejo-Marín, M; Uyenoyama, MK

The Evolution of Population Biology in , 2004
R. S. Singh and M. K. Uyenoyama

Papers Submitted

A method for computing the exact distribution of the genealogical history of a sample derived from a structured population in Theoretical Population Biology 0, 2013
Seiji Kumagai and M.K. Uyenoyama

A method for computing the exact distribution of speciation times and internode lengths in genealogical histories in Theoretical Population Biology 2012
Kumagai, S; Uyenoyama, MK

Awards

  • 1996 Fellowship for Biomedical and Behavioral Research, Fogarty International Center (NIH) and Japan Society for the Promotion of Science

  • 1992 Sabbatical Award in Molecular Studies of Evolution, Alfred P. Sloan Foundation

  • 1991 Karlin Prize for Mathematical Evolutionary Theory, American Society of Naturalists

  • 1978 Frances Lou Kallman Award, Stanford University

  • 1978 National Needs Fellow, National Science Foundation

  • 1975 Graduate Fellow, National Science Foundation