L. Ryan Baugh

Associate Professor of Biology

4314 French Family Science Center, Duke Box 90338, Durham, NC 27708
Campus Box: 
Duke Box 90338, Durham, NC 27708-4129
(919) 613-8179
We study nutritional control of development in the roundworm Caenorhabditis elegans. We are interested in the signaling pathways and gene regulatory mechanisms that enable the worm to reversibly arrest development and resist stress in response to starvation. We are also interested in epigenetic mechanisms that mediate transgenerational effects of starvation.


  • Ph.D., Harvard University 2004

  • B.S., University of Georgia at Athens 1997

Webster, AK, Jordan, JM, Hibshman, JD, Chitrakar, R, and Baugh, LR. "Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in Caenorhabditis elegans." Genetics (July 26, 2018). Full Text

Hibshman, JD, Doan, AE, Moore, BT, Kaplan, RE, Hung, A, Webster, AK, Bhatt, DP, Chitrakar, R, Hirschey, MD, and Baugh, LR. "daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival." eLife 6 (October 24, 2017). Full Text

Fradin, H, Kiontke, K, Zegar, C, Gutwein, M, Lucas, J, Kovtun, M, Corcoran, DL, Baugh, LR, Fitch, DHA, Piano, F, and Gunsalus, KC. "Genome Architecture and Evolution of a Unichromosomal Asexual Nematode." Current Biology : Cb 27, no. 19 (October 2017): 2928-2939.e6. Full Text

Burton, NO, Furuta, T, Webster, AK, Kaplan, REW, Baugh, LR, Arur, S, and Horvitz, HR. "Insulin-like signalling to the maternal germline controls progeny response to osmotic stress." Nature cell biology 19, no. 3 (March 2017): 252-257. Full Text

Hibshman, JD, Hung, A, and Baugh, LR. "Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance." Plos Genetics 12, no. 10 (October 26, 2016): e1006396-null. Full Text Open Access Copy

Kaplan, REW, and Baugh, LR. "L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development." Worm 5, no. 2 (April 6, 2016): e1175196-. Full Text Open Access Copy

Kaplan, REW, Chen, Y, Moore, BT, Jordan, JM, Maxwell, CS, Schindler, AJ, and Baugh, LR. "dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest." PLoS genetics 11, no. 12 (December 11, 2015): e1005731-. Full Text Open Access Copy

Jobson, MA, Jordan, JM, Sandrof, MA, Hibshman, JD, Lennox, AL, and Baugh, LR. "Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans." Genetics 201, no. 1 (September 2015): 201-212. Full Text Open Access Copy

Chen, Y, and Baugh, LR. "Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest." Developmental Biology 394, no. 2 (October 15, 2014): 314-326. Full Text


Baugh, LR, Hill-Harfe, K, Hill, AA, Wen, JC, Slonim, DK, Brown, EL, and Hunter, CP. "Characterization of the C-elegans embryonic regulatory network specified by PAL-1." July 15, 2003.

Selected Grants

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2021

Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020

Systemic, maternal and transgenerational effects of nutrient stress awarded by National Institutes of Health (Principal Investigator). 2015 to 2019

Dissection on an Insulin-Like Signaling Network Controlling C. elegans Development awarded by National Science Foundation (Principal Investigator). 2011 to 2017

Genome-wide quantitative genetic analysis of growth and starvation survival awarded by National Institutes of Health (Principal Investigator). 2014 to 2017

COPAS BIOSORT Worm Sorter awarded by National Institutes of Health (Collaborator). 2009 to 2010