L. Ryan Baugh

Associate Professor of Biology

4314 French Family Science Center, Duke Box 90338, Durham, NC 27708
Campus Box: 
Duke Box 90338, Durham, NC 27708-4129
(919) 613-8179
We study nutritional control of development in the roundworm Caenorhabditis elegans. We are interested in the signaling pathways and gene regulatory mechanisms that enable the worm to reversibly arrest development and resist stress in response to starvation. We are also interested in epigenetic mechanisms that mediate transgenerational effects of starvation.


  • Ph.D., Harvard University 2004

  • B.S., University of Georgia at Athens 1997

Heng, X, Cui, X, Erickson, D, Baugh, LR, Sternberg, PW, Psaltis, D, and Yang, C. "A compact optofluidic microscope." Proceedings of SPIE - The International Society for Optical Engineering 6329 (2006). Full Text

Baugh, LR, Hill, AA, Claggett, JM, Hill-Harfe, K, Wen, JC, Slonim, DK, Brown, EL, and Hunter, CP. "The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo." Development 132, no. 8 (April 2005): 1843-1854. Full Text

Baugh, LR, Wen, JC, Hill, AA, Slonim, DK, Brown, EL, and Hunter, CP. "Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions." Genome Biol 6, no. 5 (2005): R45-. Full Text Open Access Copy

Baugh, LR, Hill, AA, Slonim, DK, Brown, EL, and Hunter, CP. "Composition and dynamics of the Caenorhabditis elegans early embryonic transcriptome." Development 130, no. 5 (2003): 889-900. Full Text

Huet, F, Lu, JT, Myrick, KV, Baugh, LR, Crosby, MA, and Gelbart, WM. "A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation." Proceedings of the National Academy of Sciences of the United States of America 99, no. 15 (2002): 9948-9953. Full Text

Harvey, AJ, Speksnijder, G, Baugh, LR, Morris, JA, and Ivarie, R. "Expression of exogenous protein in the egg white of transgenic chickens." Nature Biotechnology 20, no. 4 (2002): 396-399. Full Text

Harvey, AJ, Speksnijder, G, Baugh, LR, Morris, JA, and Ivarie, R. "Consistent production of transgenic chickens using replication-deficient retroviral vectors and high-throughput screening procedures." Poultry Science 81, no. 2 (2002): 202-212.

Baugh, LR, Hill, AA, Brown, EL, and Hunter, CP. "Quantitative analysis of mRNA amplification by in vitro transcription." Nucleic acids research 29, no. 5 (2001): E29-.

Zhang, G, Deng, E, Baugh, L, and Kushner, SR. "Identification and characterization of Escherichia coli DNA helicase II mutants that exhibit increased unwinding efficiency." Journal of Bacteriology 180, no. 2 (1998): 377-387.

Zhang, G, Deng, E, Baugh, LR, Hamilton, CM, Maples, VF, and Kushner, SR. "Conserved motifs II to VI of DNA helicase II from Escherichia coli are all required for biological activity." Journal of Bacteriology 179, no. 23 (1997): 7544-7550.