L. Ryan Baugh

Associate Professor of Biology

4314 French Family Science Center, Duke Box 90338, Durham, NC 27708
Campus Box: 
Duke Box 90338, Durham, NC 27708-4129
(919) 613-8179
We study nutritional control of development in the roundworm Caenorhabditis elegans. We are interested in the signaling pathways and gene regulatory mechanisms that enable the worm to reversibly arrest development and resist stress in response to starvation. We are also interested in epigenetic mechanisms that mediate transgenerational effects of starvation.


  • Ph.D., Harvard University 2004

  • B.S., University of Georgia at Athens 1997

Burton, NO, Furuta, T, Webster, AK, Kaplan, REW, Baugh, LR, Arur, S, and Horvitz, HR. "Insulin-like signalling to the maternal germline controls progeny response to osmotic stress." Nature cell biology 19, no. 3 (March 2017): 252-257. Full Text

Kaplan, REW, and Baugh, LR. "L1 arrest, daf-16/FoxO and nonautonomous control of post-embryonic development." Worm 5, no. 2 (April 6, 2016): e1175196-. Full Text Open Access Copy

Kaplan, REW, Chen, Y, Moore, BT, Jordan, JM, Maxwell, CS, Schindler, AJ, and Baugh, LR. "dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest." PLoS genetics 11, no. 12 (December 11, 2015): e1005731-. Full Text Open Access Copy

Jobson, MA, Jordan, JM, Sandrof, MA, Hibshman, JD, Lennox, AL, and Baugh, LR. "Transgenerational Effects of Early Life Starvation on Growth, Reproduction, and Stress Resistance in Caenorhabditis elegans." Genetics 201, no. 1 (September 2015): 201-212. Full Text Open Access Copy

Maxwell, CS, Kruesi, WS, Core, LJ, Kurhanewicz, N, Waters, CT, Lewarch, CL, Antoshechkin, I, Lis, JT, Meyer, BJ, and Baugh, LR. "Pol II docking and pausing at growth and stress genes in C. elegans." Cell reports 6, no. 3 (February 2014): 455-466. Full Text Open Access Copy

Chen, Y, and Baugh, LR. "Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest." Developmental Biology 394, no. 2 (January 1, 2014): 314-326. Full Text Open Access Copy

Moore, BT, Jordan, JM, and Baugh, LR. "WormSizer: high-throughput analysis of nematode size and shape." PLoS One 8, no. 2 (2013): e57142-. Full Text Open Access Copy


Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Organization and Function of Cellular Structure awarded by National Institutes of Health (Mentor). 1975 to 2020

Dissection on an Insulin-Like Signaling Network Controlling C. elegans Development awarded by National Science Foundation (Principal Investigator). 2011 to 2017

Genome-wide quantitative genetic analysis of growth and starvation survival awarded by National Institutes of Health (Principal Investigator). 2014 to 2017

COPAS BIOSORT Worm Sorter awarded by National Institutes of Health (Collaborator). 2009 to 2010