Kenneth Daniel Poss

James B. Duke Professor of Cell Biology

307 Research Drive, Nanaline Bldg Room 466 A, Durham, NC 27710
Campus Box: 
Duke Box 3709, Durham, NC 27710
(919) 681-8457
Modeling disease in zebrafish
Genetic approaches to organ regeneration
Cardiac regeneration
Appendage regeneration
Developmental biology


  • Postdoctoral Fellow, Cardiology, Children's Hospital 2000 - 2003

  • Research Fellow, University of Utah 1998 - 2000

  • Ph.D., Massachusetts Institute of Technology 1998

Major, RJ, and Poss, KD. "III. Does heart regeneration occur?: B. Zebrafish heart regeneration." In Heart Regeneration: Stem Cells and Beyond, 59-80. January 1, 2012. Full Text

Wopat, S, Bagwell, J, Sumigray, KD, Dickson, AL, Huitema, LFA, Poss, KD, Schulte-Merker, S, and Bagnat, M. "Spine Patterning Is Guided by Segmentation of the Notochord Sheath." Cell reports 22, no. 8 (February 2018): 2026-2038. Full Text

Yang, XH, Nadadur, RD, Hilvering, CR, Bianchi, V, Werner, M, Mazurek, SR, Gadek, M, Shen, KM, Goldman, JA, Tyan, L, Bekeny, J, Hall, JM, Lee, N, Perez-Cervantes, C, Burnicka-Turek, O, Poss, KD, Weber, CR, de Laat, W, Ruthenburg, AJ, and Moskowitz, IP. "Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm." eLife 6 (December 27, 2017). Full Text

Chen, C-H, and Poss, KD. "Regeneration Genetics." Annual review of genetics 51 (November 2017): 63-82. Full Text

Cao, J, Wang, J, Jackman, CP, Cox, AH, Trembley, MA, Balowski, JJ, Cox, BD, De Simone, A, Dickson, AL, Di Talia, S, Small, EM, Kiehart, DP, Bursac, N, and Poss, KD. "Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue." Developmental cell 42, no. 6 (September 2017): 600-615.e4. Full Text

Tornini, VA, Thompson, JD, Allen, RL, and Poss, KD. "Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration." Development (Cambridge, England) 144, no. 16 (August 2017): 2889-2895. Full Text

Tzahor, E, and Poss, KD. "Cardiac regeneration strategies: Staying young at heart." Science (New York, N.Y.) 356, no. 6342 (June 8, 2017): 1035-1039. (Review) Full Text

Karra, R, and Poss, KD. "Redirecting cardiac growth mechanisms for therapeutic regeneration." The Journal of clinical investigation 127, no. 2 (February 2017): 427-436. (Review) Full Text

Goldman, JA, Kuzu, G, Lee, N, Karasik, J, Gemberling, M, Foglia, MJ, Karra, R, Dickson, AL, Sun, F, Tolstorukov, MY, and Poss, KD. "Resolving Heart Regeneration by Replacement Histone Profiling." Developmental cell 40, no. 4 (February 2017): 392-404.e5. Full Text

Nichols, JT, Blanco-Sánchez, B, Brooks, EP, Parthasarathy, R, Dowd, J, Subramanian, A, Nachtrab, G, Poss, KD, Schilling, TF, and Kimmel, CB. "Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca." Development (Cambridge, England) 143, no. 23 (December 2016): 4430-4440. Full Text

Tornini, VA, Puliafito, A, Slota, LA, Thompson, JD, Nachtrab, G, Kaushik, A-L, Kapsimali, M, Primo, L, Di Talia, S, and Poss, KD. "Live Monitoring of Blastemal Cell Contributions during Appendage Regeneration." Current biology : CB 26, no. 22 (November 3, 2016): 2981-2991. Full Text


Selected Grants

Medical Scientist Training Program awarded by National Institutes of Health (Mentor). 1997 to 2022

Regulation of Myocardial Regeneration in Zebrafish awarded by National Institutes of Health (Principal Investigator). 2005 to 2022

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2022

Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health (Mentor). 1975 to 2021

Polyploidy in Cardiac Development and Tissue Repair in Drosophila awarded by National Institutes of Health (Co-Sponsor). 2018 to 2020

Eliciting heart regeneration through cardiomyocyte division awarded by Fondation Leducq (Principal Investigator). 2016 to 2020

Identification and application of regulatory elements for heart regeneration awarded by National Institutes of Health (Principal Investigator). 2016 to 2020

Pronobis - 2017: Bioactive peptides as modulators of tissue regeneration awarded by Life Sciences Research Foundation (Principal Investigator). 2017 to 2020

Identifying a transcription factor collective that specifies cardiomyocyte regeneration awarded by American Heart Association (Principal Investigator). 2017 to 2020

Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020