Katharina V. Koelle

Associate Professor in the Department of Biology

Office: 
130 Science Drive, Room 137, Duke Box 90338, Durham, NC 27708
Campus Box: 
Duke Box 90338, Durham, NC 27708-4129
Phone: 
(919) 660-9457
My research focuses on the ecology and evolution of infectious diseases. I use a combination of mathematical and statistical approaches to understand the processes driving the disease dynamics of pathogens. My interests include developing models to improve our understanding of how immune escape and other viral phenotypes impact the ecological dynamics of RNA viruses, and, in turn, how these ecological dynamics create selection pressures on viral pathogens. Additional interests include developing within-host models of viral dynamics and evolution and fitting these models to empirical data. Current research projects focus primarily on influenza and dengue.

Education

  • Ph.D., University of Michigan at Ann Arbor 2005

Sobel Leonard, A, McClain, MT, Smith, GJD, Wentworth, DE, Halpin, RA, Lin, X, Ransier, A, Stockwell, TB, Das, SR, Gilbert, AS, Lambkin-Williams, R, Ginsburg, GS, Woods, CW, Koelle, K, and Illingworth, CJR. "The effective rate of influenza reassortment is limited during human infection." PLoS pathogens 13, no. 2 (February 7, 2017): e1006203-. Full Text

Sobel Leonard, A, McClain, MT, Smith, GJD, Wentworth, DE, Halpin, RA, Lin, X, Ransier, A, Stockwell, TB, Das, SR, Gilbert, AS, Lambkin-Williams, R, Ginsburg, GS, Woods, CW, and Koelle, K. "Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification." Journal of virology 90, no. 24 (December 2016): 11247-11258. Full Text

Flasche, S, Jit, M, Rodríguez-Barraquer, I, Coudeville, L, Recker, M, Koelle, K, Milne, G, Hladish, TJ, Perkins, TA, Cummings, DAT, Dorigatti, I, Laydon, DJ, España, G, Kelso, J, Longini, I, Lourenco, J, Pearson, CAB, Reiner, RC, Mier-y-Terán-Romero, L, Vannice, K, and Ferguson, N. "The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): A Model Comparison Study." Edited by L von Seidlein. PLOS Medicine 13, no. 11 (November 29, 2016): e1002181-e1002181. Full Text

Ben-Shachar, R, Schmidler, S, and Koelle, K. "Drivers of Inter-individual Variation in Dengue Viral Load Dynamics." Edited by NM Ferguson. PLOS Computational Biology 12, no. 11 (November 17, 2016): e1005194-e1005194. Full Text

Rasmussen, DA, Volz, EM, and Koelle, K. "Phylodynamic inference for structured epidemiological models." PLoS computational biology 10, no. 4 (April 17, 2014): e1003570-. Full Text Open Access Copy

Koelle, K, and Rasmussen, DA. "Influenza: Prediction is worth a shot." Nature 507, no. 7490 (March 2014): 47-48. Full Text

Rasmussen, DA, Boni, MF, and Koelle, K. "Reconciling phylodynamics with epidemiology: the case of dengue virus in southern Vietnam." Molecular biology and evolution 31, no. 2 (February 2014): 258-271. Full Text Open Access Copy

Pages

Genetics Training Grant awarded by National Institutes of Health (Mentor). 1979 to 2020

Antibody and viral determinants of protection against CMV infection following gB/MF59 vaccination awarded by National Institutes of Health (Preceptor). 2017 to 2020

One Health Innovation Fellowships for Zoonotic Disease Research in Mongolia awarded by National Institutes of Health (Mentor). 2013 to 2018

Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health (Mentor). 2001 to 2017

Center for Statistics and Quantitative Infectious Diseases awarded by Fred Hutchinson Cancer Research Center (Principal Investigator). 2016 to 2017

Medical Scientist Training Program awarded by National Institutes of Health (Mentor). 1997 to 2017

Center for Statistics and Quantitative Infectious Diseases awarded by Fred Hutchinson Cancer Research Center (Principal Investigator). 2014 to 2016

Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health (Mentor). 2005 to 2016

Implementation Science to Optimize Malaria Vector Control and Disease Management awarded by National Institutes of Health (Co Investigator). 2010 to 2015

Combining ecological and molecular models to understand the evolutionary dynamics of influenza awarded by National Science Foundation (Principal Investigator). 2008 to 2013