John H. Willis

Professor of Biology

Office: 
3314 French Science Center, Science Drive, Durham, NC 27708
Campus Box: 
90338
Phone: 
(919) 660-7340
Fax: 
(919) 660-7293

Lab Site: http://www.biology.duke.edu/willislab

Research Interests: 

We conduct research on broad issues in evolutionary genetics, and we are currently addressing questions relating to the evolution of adaptation, reproductive isolation, breeding systems, inbreeding depression, and floral traits in natural plant populations. Please see our lab web page for more information.

We conduct research on broad issues in
evolutionary genetics, and we
are currently addressing questions relating to
the evolution of adaptation, reproductive isolation,
breeding systems, inbreeding depression, and
floral traits in natural plant populations.
Please see our lab web page for more
information.

Education

  • Ph.D. 1991, University of Chicago

Papers Published

Metagenome-Assembled Draft Genome Sequence of a Novel Microbial Stenotrophomonas maltophilia Strain Isolated from Caenorhabditis remanei Tissue , 2, 2017
Fierst, JL; Murdock, DA; Thanthiriwatte, C; Willis, JH; Phillips, PC, Genome Announcements. 5 vol. (7); pp. e01646-16-e01646-16

The genetic architecture of local adaptation and reproductive isolation in sympatry within the Mimulus guttatus species complex., 1, 2017
Ferris, KG; Barnett, LL; Blackman, BK; Willis, JH, Molecular Ecology. 26 vol. (1); pp. 208-224

Population structure and local selection yield high genomic variation in Mimulus guttatus., 1, 2017
Puzey, JR; Willis, JH; Kelly, JK, Molecular Ecology. 26 vol. (2); pp. 519-535

A Segregating Inversion Generates Fitness Variation in Yellow Monkeyflower (Mimulus guttatus)., 4, 2016
Lee, YW; Fishman, L; Kelly, JK; Willis, JH, Genetics. 202 vol. (4); pp. 1473-1484

Correction: Reproductive Mode and the Evolution of Genome Size and Structure in Caenorhabditis Nematodes, 9, 2015
Fierst, JL; Willis, JH; Thomas, CG; Wang, W; Reynolds, RM; Ahearne, TE; Cutter, AD; Phillips, PC, PLoS genetics. 11 vol. (9); pp. e1005497-e1005497

Leaf shape evolution has a similar genetic architecture in three edaphic specialists within the Mimulus guttatus species complex., 8, 2015
Ferris, KG; Rushton, T; Greenlee, AB; Toll, K; Blackman, BK; Willis, JH, Annals of Botany (Elsevier). 116 vol. (2); pp. 213-223

Reproductive Mode and the Evolution of Genome Size and Structure in Caenorhabditis Nematodes, 6, 2015
Fierst, JL; Willis, JH; Thomas, CG; Wang, W; Reynolds, RM; Ahearne, TE; Cutter, AD; Phillips, PC, PLoS genetics. 11 vol. (6); pp. e1005323-e1005323

The extent and genetic basis of phenotypic divergence in life history traits in Mimulus guttatus., 1, 2015
Friedman, J; Twyford, AD; Willis, JH; Blackman, BK, Molecular Ecology. 24 vol. (1); pp. 111-122

Speciation on a local geographic scale: the evolution of a rare rock outcrop specialist in Mimulus., 8, 2014
Ferris, KG; Sexton, JP; Willis, JH, Philosophical Transactions B. 369 vol. (1648);

Divergent population structure and climate associations of a chromosomal inversion polymorphism across the Mimulus guttatus species complex., 6, 2014
Oneal, E; Lowry, DB; Wright, KM; Zhu, Z; Willis, JH, Molecular Ecology. 23 vol. (11); pp. 2844-2860

The standing pool of genomic structural variation in a natural population of Mimulus guttatus., 1, 2014
Flagel, LE; Willis, JH; Vision, TJ, Genome Biology and Evolution. 6 vol. (1); pp. 53-64

Comparative linkage maps suggest that fission, not polyploidy, underlies near-doubling of chromosome number within monkeyflowers (Mimulus; Phrymaceae), 1, 2014
Fishman, L; Willis, JH; Wu, CA; Lee, YW, Heredity. 112 vol. (5); pp. 562-568

Fine-scale variation in meiotic recombination in Mimulus inferred from population shotgun sequencing, 11, 2013
Hellsten, U; Wright, KM; Jenkins, J; Shu, S; Yuan, Y; Wessler, SR; Schmutz, J; Willis, JH; Rokhsar, DS, Proceedings of the National Academy of Sciences of USA. 110 vol. (48); pp. 19478-19482

Major QTLs for critical photoperiod and vernalization underlie extensive variation in flowering in the Mimulus guttatus species complex, 0, 2013
Friedman, J; Willis, JH, New Phytologist. 199 vol. (2); pp. 571-583

Indirect evolution of hybrid lethality due to linkage with selected locus in Mimulus guttatus., 0, 2013
Wright, KM; Lloyd, D; Lowry, DB; Macnair, MR; Willis, JH, PLoS biology. 11 vol. (2); pp. e1001497

Allotetraploid Mimulus sookensis are highly interfertile despite independent origins., 11, 2012
Modliszewski, JL; Willis, JH, Molecular Ecology. 21 vol. (21); pp. 5280-5298

Five anthocyanin polymorphisms are associated with an R2R3-MYB cluster in Mimulus guttatus (Phrymaceae)., 1, 2012
Lowry, DB; Sheng, CC; Lasky, JR; Willis, JH, American journal of botany. 99 vol. (1); pp. 82-91

Major QTLs for critical photoperiod and vernalization underlie extensive variation in flowering time in the Mimulus guttatus species complex., 0, 2012
Friedman, J; Willis, JH, New Phytologist.

Molecular evolution and genetics of postzygotic reproductive isolation in plants., 0, 2012
Sweigart, AL; Willis, JH, F1000 Biology Reports. 4 pp. 23

Evidence against equimolarity of large repeat arrangements and a predominant master circle structure of the mitochondrial genome from a monkeyflower (Mimulus guttatus) lineage with cryptic CMS, 0, 2012
Mower, JP; Case, AL; Floro, ER; Willis, JH, Genome Biology and Evolution. 4 vol. (5); pp. 670-686

Spatially and temporally varying selection on intrapopulation quantitative trait loci for a life history trade-off in Mimulus guttatus, 0, 2012
Mojica, JP; Lee, YW; Willis, JH; Kelly, JK, Molecular Ecology. 21 vol. (15); pp. 3718-3728

Mapping of ionomic traits in Mimulus guttatus reveals Mo and Cd QTLs that colocalize with MOT1 homologues., 2012
Lowry, DB; Sheng, CC; Zhu, Z; Juenger, TE; Lahner, B; Salt, DE; Willis, JH, PloS one. (2012) 7 vol. (1); pp. e30730

Mimulus sookensis (Phyrmaceae), a new allotetraploid species derived from Mimulus guttatus and Mimulus nasutus., 0, 2012
Benedict, BG; Modliszewski, JL; Sweigart, AL; Martin, NH; Ganders, FR; Willis, JH, Madrono. 59 pp. 29-43

Genetic evidence for hybridization in red oaks (Quercus sect. Lobatae, Fagaceae), 0, 2012
Moran, EV; Willis, J; Clark, JS, American journal of botany. 99 vol. (1); pp. 92-100

What can patterns of differentiation across plant genomes tell us about adaptation and speciation?, 2012
Strasburg, JL; Sherman, NA; Wright, KM; Moyle, LC; Willis, JH; Rieseberg, LH, Philosophical Transactions B. (2012) 367 vol. (1587); pp. 364-373

Evolutionary genetics of plant adaptation., 7, 2011
Anderson, JT; Willis, JH; Mitchell-Olds, T, Trends in Genetics. 27 vol. (7); pp. 258-266

Gene duplication in Mimulus underlies parallel floral evolution via independent trans-regulatory changes., 2011
Cooley, AM; Modliszewski, JL; Rommel, ML; Willis, JH, Current Biology. (2011) 21 vol. (8); pp. 700-704

The statistics of bulk segregant analysis using next generation sequencing., 11, 2011
Magwene, PM; Willis, JH; Kelly, JK, PLoS computational biology. 7 vol. (11); pp. e1002255

The ecology and genetics of Mimulus, 0, 2011
Willis, JH; Fishman, L; Sweigart, A, Annual Review of Ecology, Evolution, and Systematics. 42

Explaining the heritability of an ecologically significant trait in terms of individual quantitative trait loci, 2011
Scoville, AG; Lee, YW; Willis, JH; Kelly, JK, Biology Letters. (2011) 7 vol. (6); pp. 896-898

A widespread chromosomal inversion polymorphism contributes to a major life-history transition, local adaptation, and reproductive isolation., 9, 2010
Lowry, DB; Willis, JH, PLoS biology. 8 vol. (9); pp. e1000500

Natural variation for drought-response traits in the Mimulus guttatus species complex., 2010
Wu, CA; Lowry, DB; Nutter, LI; Willis, JH, Oecologia. (2010) 162 vol. (1); pp. 23-33

Geographical variation in postzygotic isolation and its genetic basis within and between two Mimulus species, 2010
Martin, NH; Willis, JH, Philosophical Transactions B. (2010) 365 vol. (1552); pp. 2469-2478

Is local adaptation in Mimulus guttatus caused by trade-offs at individual loci?, 2010
Hall, MC; Lowry, DB; Willis, JH, Molecular Ecology. (2010) 19 vol. (13); pp. 2739-2753

Erratum: Geographical variation in postzygotic isolation and its genetic basis within and between two Mimulus species (Philosophical Transactions of the Royal Society B: Biological Sciences (2010) 365 (2469-2478) DOI: 10.1098/rstb.2010.0030), 0, 2010
Martin, NH; Willis, JH, Philosophical Transactions B. 365 vol. (1555); pp. 3261-

Genetic divergence causes parallel evolution of flower color in Chilean Mimulus., 8, 2009
Cooley, AM; Willis, JH, New Phytologist. 183 vol. (3); pp. 729-739

Genetic and physiological basis of adaptive salt tolerance divergence between coastal and inland Mimulus guttatus., 8, 2009
Lowry, DB; Hall, MC; Salt, DE; Willis, JH, New Phytologist. 183 vol. (3); pp. 776-788

Genetics. Origin of species in overdrive., 1, 2009
Willis, JH, Science. 323 vol. (5912); pp. 350-351

Origin of species in overdrive, 2009
Willis, JH, Science. (2009) 323 vol. (5912); pp. 350-351

The genetics of inbreeding depression, 0, 2009
Charlesworth, D; Willis, JH, Nature Reviews Genetics. 10 vol. (11); pp. 783-796

Contribution of chromosomal polymorphisms to the G-matrix of Mimulus guttatus, 0, 2009
Scoville, A; Lee, YW; Willis, JH; Kelly, JK, New Phytologist. 183 vol. (3); pp. 803-815

Ecological reproductive isolation of coast and inland races of Mimulus guttatus., 9, 2008
Lowry, DB; Rockwood, RC; Willis, JH, Evolution. 62 vol. (9); pp. 2196-2214

Review. The strength and genetic basis of reproductive isolating barriers in flowering plants., 9, 2008
Lowry, DB; Modliszewski, JL; Wright, KM; Wu, CA; Willis, JH, Philosophical Transactions B. 363 vol. (1506); pp. 3009-3021

The strength and genetic basis of reproductive isolating barriers in flowering plants, 9, 2008
Lowry, DB; Modliszewski, JL; Wright, KM; Wu, CA; Willis, JH, Philosophical Transactions B. 363 vol. (1506); pp. 3009-3021

The genetic basis of developmental abnormalities in interpopulation hybrids of the moss Ceratodon purpureus., 7, 2008
McDaniel, SF; Willis, JH; Shaw, AJ, Genetics. 179 vol. (3); pp. 1425-1435

Hybrid male sterility in Mimulus (Phrymaceae) is associated with a geographically restricted mitochondrial rearrangement., 5, 2008
Case, AL; Willis, JH, Evolution. 62 vol. (5); pp. 1026-1039

Is floral diversification associated with pollinator divergence? Flower shape, flower colour and pollinator preference in Chilean Mimulus., 4, 2008
Cooley, AM; Carvallo, G; Willis, JH, Annals of Botany (Elsevier). 101 vol. (5); pp. 641-650

Mimulus is an emerging model system for the integration of ecological and genomic studies., 2, 2008
Wu, CA; Lowry, DB; Cooley, AM; Wright, KM; Lee, YW; Willis, JH, Heredity. 100 vol. (2); pp. 220-230

Patterns of nucleotide variation and reproductive isolation between a Mimulus allotetraploid and its progenitor species, 2008
Sweigart, AL; Martin, NH; Willis, JH, Molecular Ecology. (2008) 17 vol. (8); pp. 2089-2100

Pollen limitation and natural selection on floral characters in the yellow monkeyflower, Mimulus guttatus, 2008
Fishman, L; Willis, JH, New Phytologist. (2008) 177 vol. (3); pp. 802-810

A linkage map reveals a complex basis for segregation distortion in an interpopulation cross in the moss Ceratodon purpureus., 8, 2007
McDaniel, SF; Willis, JH; Shaw, AJ, Genetics. 176 vol. (4); pp. 2489-2500

Which evolutionary processes influence natural genetic variation for phenotypic traits?, 11, 2007
Mitchell-Olds, T; Willis, JH; Goldstein, DB, Nature Reviews Genetics. 8 vol. (11); pp. 845-856

Natural variation for a hybrid incompatibility between two species of Mimulus., 2007
Sweigart, AL; Mason, AR; Willis, JH, Evolution. (2007) 61 vol. (1); pp. 141-151

Ecological divergence associated with mating system causes nearly complete reproductive isolation between sympatric mimulus species, 2007
Martin, NH; Willis, JH, Evolution. (2007) 61 vol. (1); pp. 68-82

Plant speciation, 0, 2007
Rieseberg, LH; Willis, JH, Science. 317 vol. (5840); pp. 910-914

What evolutionary processes influence natural genetic variation for phenotypic traits?, 0, 2007
Mitchell Olds, T; Willis, JH; Goldstein, D, Nature Reviews Genetics. 8 vol. (11); pp. 845-856

A simple genetic incompatibility causes hybrid male sterility in mimulus., April, 2006
Sweigart, AL; Fishman, L; Willis, JH, Genetics. (April, 2006) 172 vol. (4); pp. 2465-2479

Pleiotropic quantitative trait loci contribute to population divergence in traits associated with life-history variation in Mimulus guttatus., March, 2006
Hall, MC; Basten, CJ; Willis, JH, Genetics. (March, 2006) 172 vol. (3); pp. 1829-1844

Divergent selection on flowering time contributes to local adaptation in Mimulus guttatus populations, 2006
Hall, MC; Willis, JH, Evolution. (2006) 60 vol. (12); pp. 2466-2477

Relaxed selection among duplicate floral regulatory genes in Lamiales, 2006
Aagaard, JE; Willis, JH; Phillips, PC, Journal of Molecular Evolution. (2006) 63 vol. (4); pp. 493-503

A cytonuclear incompatibility causes anther sterility in Mimulus hybrids, 2006
Fishman, L; Willis, JH, Evolution. (2006) 60 vol. (7); pp. 1372-1381

Transmission ratio distortion in intraspecific hybrids of Mimulus guttatus: implications for genomic divergence., 5, 2005
Hall, MC; Willis, JH, Genetics. 170 vol. (1); pp. 375-386

Duplication of floral regulatory genes in the Lamiales, 0, 2005
Aagaard, JE; Olmstead, RG; Willis, JH; Phillips, PC, American Journal of Botany. 92 vol. (8); pp. 1284-1293

A novel meiotic drive locus almost completely distorts segregation in Mimulus (monkeyflower) hybrids, 0, 2005
Fishman, L; Willis, JH, Genetics. 169 vol. (1); pp. 347-353

Patterns of nucleotide diversity are affected by mating system and asymmetric introgression in two species of Mimulus, 11, 2003
Sweigart, AL; Willis, JH, Evolution. 57 vol. (11); pp. 2490-2506

Patterns of nucleotide diversity in two species of Mimulus are affected by mating system and asymmetric introgression., 11, 2003
Sweigart, AL; Willis, JH, Evolution. 57 vol. (11); pp. 2490-2506

Minor quantitative trait loci underlie floral traits associated with mating system divergence in Mimulus., 11, 2002
Fishman, L; Kelly, AJ; Willis, JH, Evolution. 56 vol. (11); pp. 2138-2155

Minor QTLs underlie floral characters associated with mating system divergence in Mimulus, 0, 2002
Fishman, L; Kelly, AJ; Willis, JH, Evolution. 56 vol. (11); pp. 2138-2155

A manipulative experiment to estimate biparental inbreeding in monkeyflowers, 0, 2002
Kelly, JK; Willis, JH, International Journal of Plant Sciences. 163 vol. (4); pp. 575-579

A genetic map in the Mimulus guttatus species complex reveals transmission ratio distortion due to heterospecific interactions., 12, 2001
Fishman, L; Kelly, AJ; Morgan, E; Willis, JH, Genetics. 159 vol. (4); pp. 1701-1716

Evidence for Dobzhansky-Muller incompatibilites contributing to the sterility of hybrids between Mimulus guttatus and M. nasutus., 10, 2001
Fishman, L; Willis, JH, Evolution. 55 vol. (10); pp. 1932-1942

Deleterious mutations and genetic variation for flower size in Mimulus guttatus, 0, 2001
Kelly, JK; Willis, JH, Evolution. 55 vol. (5); pp. 937-942

Spontaneous deleterious mutation in Arabidopsis thaliana, 0, 1999
Schultz, ST; Lynch, M; Willis, JH, Proceedings of the National Academy of Sciences of USA. 96 vol. (20); pp. 11393-11398

Spontaneous deleterious mutation, 0, 1999
Lynch, M; Blanchard, J; Houle, D; Kibota, T; Schultz, S; Vassilieva, L; Willis, JH, Evolution. 53 vol. (3); pp. 645-663

The genomic mutation rate for fitness in Arabidopsis thaliana, 0, 1999
Schultz, ST; Lynch, M; Willis, JH, Procedings of the National Academy of Science, USA. 96 pp. 11393-11398

The contribution of male-sterility mutations to inbreeding depression in Mimulus guttatus, 0, 1999
Willis, JH, Heredity. 83 vol. (3); pp. 337-346

The distribution of individual inbreeding coefficients and pairwise relatedness in a population of Mimulus guttatus, 0, 1999
Sweigart, A; Karoly, K; Jones, A; Willis, JH, Heredity. 83 vol. (5); pp. 625-632

Inbreeding load, average dominance and the mutation rate for mildly deleterious alleles in Mimulus guttatus, 0, 1999
Willis, JH, Genetics. 153 vol. (4); pp. 1885-1898

The role of genes of large effect on inbreeding depression in Mimulus guttatus, 0, 1999
Willis, JH, Evolution. 53 vol. (6); pp. 1678-1691

Perspective: Spontaneous deleterious mutation, 0, 1999
Lynch, M; Blanchard, J; Houle, D; Kibota, T; Schultz, S; Vassilieva, L; Willis, J, Evolution. 53 vol. (3); pp. 645-663

Polymorphic microsatellite loci in Mimulus guttatus and related species, 0, 1998
Kelly, AJ; Willis, JH, Molecular Ecology. 7 vol. (6); pp. 769-774

Measures of phenotypic selection are biased by partial inbreeding, 1996
Willis, JH, Evolution. (1996) 50 vol. (4); pp. 1501-1511

Individual variation in inbreeding depression: The roles of inbreeding history and mutation, 1995
Schultz, ST; Willis, JH, Genetics. (1995) 141 vol. (3); pp. 1209-1223

Linearity vs. nonlinearity of offspring-parent regression: experimental study., 1994
Gimelfarb, A; Willis, JH, Genetics. (1994) 138 vol. (2); pp. 343-352

Linearity versus nonlinearity of offspring-parent regression: An experimental study of Drosophila melanogaster, 0, 1994
Gimelfarb, A; Willis, JH, Genetics. 138 vol. (2); pp. 343-352

Increased heritable variation following population bottlenecks: The role of dominance., 1993
Willis, JH; Orr, HA, Evolution. (1993) 47 pp. 949-957

Partial self-fertilization and inbreeding depression in two populations of Mimulus guttatus, 1993
Willis, JH, Heredity. (1993) 71 vol. (2); pp. 145-154

Effects of different levels of inbreeding on fitness components in Mimulus guttatus, 1993
Willis, JH, Evolution. (1993) 47 vol. (3); pp. 864-876

Genetic analysis of inbreeding depression caused by chlorophyll-deficient lethals in Mimulus guttatus., 1992
Willis, JH, Heredity. (1992) 69 pp. 562-572

Can one predict the evolution of quantitative traits without genetics?, 1991
Willis, JH; Coyne, JA; Kirkpatrick, M, Evolution. (1991) 45 pp. 441-444

Variance in search time: Do groups always reduce risk?, 1986
Bergelson, JM; Willis, JH; Robakiewicz, PE, Animal Behaviour. (1986) 34 vol. (PART 1); pp. 289-291