H. Frederik Nijhout

John Franklin Crowell Professor of Biology

Office: 
322 Bio Sci Bldg, Durham, NC 27708
Campus Box: 
90338
Phone: 
(919) 684-2793
Fax: 
(919) 660-7293
Email: 

Lab Site: http://www.biology.duke.edu/nijhout/

Research Interests: 

Fred Nijhout is broadly interested in developmental physiology and in the interactions between development and evolution. He has several lines of research ongoing in his laboratory that on the surface may look independent from one another, but all share a conceptual interest in understanding how complex traits arise through, and are affected by, the interaction of genetic and environmental factors. 1) The control of polyphenic development in insects. This work attempts to understand how the insect developmental hormones, ecdysone and juvenile hormone, act to control alternative developmental pathways within a single individual. His studies and those of his students have dealt with the control of sequential polyphenism in metamorphosis, of alternate polyphenisms in caste determination of social insects and the many seasonal forms of insects. 2) The regulation of organ and body size in insects. Ongoing research deals with the mechanism by which insects asses their body size and stop growing when they have achieved a characteristic size. Other studies deal with the control of growth and size of imaginal disks. This work is revealing that the control of body and organ size does not reside in any specific cellular or molecular mechanism but that it is a systems property in which cellular, physiological and environmental signals all contribute in inextricable ways to produce the final phenotype. 3) The development and evolution of color patterns in Lepidoptera. Ongoing research attempts to elucidate the evolution of mimicry using genetic and genomic approaches. 4) The development, genetics and evolution of complex traits. Complex traits are those whose variation is affected by many genes and environmental factors and whose inheritance does not follow Mendel’s laws. In practice this involves understanding how genetic and developmental networks operate when there is allelic variation in their genes. This work attempts to reconstruct complex traits through mathematical models of the genetic and developmental processes by which they originate, and uses these models to study the effects of mutation and selection. Currently metabolic networks (e.g. folate metabolism) are being used to develop a deeper understanding of the functional relationships between genetic variation and trait variation, and of the mechanisms by which genetic and environmental variables interact to produce phenotypes. More on web page: http://www.biology.duke.edu/nijhout/

Fred Nijhout is broadly interested in developmental physiology and in the interactions between development and evolution. He has several lines of research ongoing in his laboratory that on the surface may look independent from one another, but all share a conceptual interest in understanding how complex traits arise through, and are affected by, the interaction of genetic and environmental factors. 1) The control of polyphenic development in insects. This work attempts to understand how the insect developmental hormones, ecdysone and juvenile hormone, act to control alternative developmental pathways within a single individual. His studies and those of his students have dealt with the control of sequential polyphenism in metamorphosis, of alternate polyphenisms in caste determination of social insects and the many seasonal forms of insects. 2) The regulation of organ and body size in insects. Ongoing research deals with the mechanism by which insects asses their body size and stop growing when they have achieved a characteristic size. Other studies deal with the control of growth and size of imaginal disks. This work is revealing that the control of body and organ size does not reside in any specific cellular or molecular mechanism but that it is a systems property in which cellular, physiological and environmental signals all contribute in inextricable ways to produce the final phenotype. 3) The development and evolution of color patterns in Lepidoptera. Ongoing research attempts to elucidate the evolution of mimicry using genetic and genomic approaches. 4) The development, genetics and evolution of complex traits. Complex traits are those whose variation is affected by many genes and environmental factors and whose inheritance does not follow Mendel’s laws. In practice this involves understanding how genetic and developmental networks operate when there is allelic variation in their genes. This work attempts to reconstruct complex traits through mathematical models of the genetic and developmental processes by which they originate, and uses these models to study the effects of mutation and selection. Currently metabolic networks (e.g. folate metabolism) are being used to develop a deeper understanding of the functional relationships between genetic variation and trait variation, and of the mechanisms by which genetic and environmental variables interact to produce phenotypes. More on web page: http://www.biology.duke.edu/nijhout/

Education

  • Ph.D. 1974, Harvard University

  • M.A. 1972, Harvard University

  • B.S. 1970, University of Notre Dame

Papers Published

Mathematical modeling of perifusion cell culture experiments on GnRH signaling., 6, 2016
Temamogullari, NE; Nijhout, HF; C Reed, M, Mathematical Biosciences. 276 pp. 121-132

The role of skeletal muscle in liver glutathione metabolism during acetaminophen overdose., 7, 2015
Bilinsky, LM; Reed, MC; Nijhout, HF, Journal of Theoretical Biology. 376 pp. 118-133

Two insulin receptors determine alternative wing morphs in planthoppers., 3, 2015
Xu, H-J; Xue, J; Lu, B; Zhang, X-C; Zhuo, J-C; He, S-F; Ma, X-F; Jiang, Y-Q; Fan, H-W; Xu, J-Y; Ye, Y-X; Pan, P-L; Li, Q; Bao, Y-Y; Nijhout, HF; Zhang, C-X, Nature. 519 vol. (7544); pp. 464-467

Using mathematical models to understand metabolism, genes, and disease., 1, 2015
Nijhout, HF; Best, JA; Reed, MC, BMC Biology. 13 pp. 79

Big or fast: two strategies in the developmental control of body size., 1, 2015
Nijhout, HF, BMC Biology. 13 pp. 57

A Quantitative Analysis of Growth and Size Regulation in Manduca sexta: The Physiological Basis of Variation in Size and Age at Metamorphosis., 1, 2015
Grunert, LW; Clarke, JW; Ahuja, C; Eswaran, H; Nijhout, HF, PloS one. 10 vol. (5); pp. e0127988

To plasticity and back again., 1, 2015
Nijhout, HF, eLife. 4

Developmental mechanisms of body size and wing-body scaling in insects., 1, 2015
Nijhout, HF; Callier, V, Annual Review of Entomology. 60 pp. 141-156

Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo., 8, 2014
Wood, KM; Zeqja, A; Nijhout, HF; Reed, MC; Best, J; Hashemi, P, Journal of Neurochemistry. 130 vol. (3); pp. 351-359

Plasticity of insect body size in response to oxygen: integrating molecular and physiological mechanisms, 7, 2014
Callier, V; Nijhout, HF, Current opinion in insect science. 1 pp. 59-65

Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells., 7, 2014
da Silva, VR; Ralat, MA; Quinlivan, EP; DeRatt, BN; Garrett, TJ; Chi, Y-Y; Frederik Nijhout, H; Reed, MC; Gregory, JF, American journal of physiology. Endocrinology and metabolism. 307 vol. (1); pp. E93-101

Homeostasis and dynamic stability of the phenotype link robustness and plasticity., 7, 2014
Nijhout, HF; Reed, MC, Integrative and Comparative Biology (BioOne). 54 vol. (2); pp. 264-275

Mathematical modeling of the effects of glutathione on arsenic methylation., 5, 2014
Lawley, SD; Yun, J; Gamble, MV; Hall, MN; Reed, MC; Nijhout, HF, Theoretical Biology and Medical Modelling. 11 pp. 20

The development of wing shape in Lepidoptera: mitotic density, not orientation, is the primary determinant of shape., 3, 2014
Nijhout, HF; Cinderella, M; Grunert, LW, Evolution and Development. 16 vol. (2); pp. 68-77

Escape from homeostasis., 11, 2014
Nijhout, HF; Best, J; Reed, MC, Mathematical Biosciences. 257 pp. 104-110

Voltammetric and mathematical evidence for dual transport mediation of serotonin clearance in vivo, 1, 2014
Wood, KM; Zeqja, A; Nijhout, HF; Reed, MC; Best, J; Hashemi, P, Journal of Neurochemistry. 130 vol. (3); pp. 351-359

The developmental control of size in insects, 1, 2014
Nijhout, HF; Riddiford, LM; Mirth, C; Shingleton, AW; Suzuki, Y; Callier, V, Wiley Interdisciplinary Reviews: Developmental Biology. 3 vol. (1); pp. 113-134

Homeostasis and dynamic stability of the phenotype: Implications for understanding the nature and evolution of robustness and plasticity, 0, 2014
Nijhout, HF; Reed, MC, Integrative and Comparative Biology (BioOne). 54 pp. E153-E153

Projecting Biochemistry Over Long Distances, 0, 2014
Reed, M; Nijhout, HF; Best, J, Mathematical Modelling of Natural Phenomena (MMNP). 9 vol. (1); pp. 133-138

A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites., September, 2013
Rios-Avila, L; Nijhout, HF; Reed, MC; Sitren, HS; Gregory, JF, The Journal of nutrition. (September, 2013) 143 vol. (9); pp. 1509-1519

A population model of folate-mediated one-carbon metabolism., July, 2013
Duncan, TM; Reed, MC; Nijhout, HF, Nutrients. (July, 2013) 5 vol. (7); pp. 2457-2474

The developmental control of size in insects, July, 2013
Nijhout HF, Riddiford LM, Mirth C Shingleton AW, Suzuki Y, Callier, V, WIREs Developmental Biology. (July, 2013) 3 pp. 113-134

Arthropod developmental endocrinology, 10, 2013
Frederik Nijhout, H, pp. 123-148

Development of polyploidy of scale-building cells in the wings of Manduca sexta., January, 2013
Cho, EH; Nijhout, HF, Arthropod Struct Dev. (January, 2013) 42 vol. (1); pp. 37-46

The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: A model, April, 2013
Duncan, TM; Reed, MC; Nijhout, HF, Mol Nutr Food Res. (April, 2013) 57 vol. (4); pp. 628-636

Computational studies of the role of serotonin in the basal ganglia, May, 2013
Best, J; Reed, MC; Nijhout, HF, Frontiers in Integrative Neuroscience. (May, 2013) 24 vol. (MAY); pp. 41

A new mathematical approach for qualitative modeling of the insulin-TOR-MAPK network., September, 2013
Nijhout, HF; Callier, V, Front Physiol. (September, 2013) 4 vol. (4); pp. 245

Multi-allelic major effect genes interact with minor effect QTLs to control adaptive color pattern variation in Heliconius erato., November, 2013
Papa, R; Kapan, DD; Counterman, BA; Maldonado, K; Lindstrom, DP; Reed, RD; Nijhout, HF; Hrbek, T; McMillan, WO, PloS one. (November, 2013) 8 vol. (3); pp. e57033

Body size determination in insects: A review and synthesis of size- and brain-dependent and independent mechanisms, November, 2013
Callier, V; Nijhout, HF, Biological Reviews. (November, 2013) 88 vol. (4); pp. 944-954

Predicting the response to simultaneous selection: genetic architecture and physiological constraints., September, 2012
Davidowitz, G; Nijhout, HF; Roff, DA, Evolution. (September, 2012) 66 vol. (9); pp. 2916-2928

Developmental causes of allometry: new models and implications for phenotypic plasticity and evolution., July, 2012
Nijhout, HF; German, RZ, Integr Comp Biol. (July, 2012) 52 vol. (1); pp. 43-52

A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism., July, 2012
Geenen, S; du Preez, FB; Reed, M; Nijhout, HF; Kenna, JG; Wilson, ID; Westerhoff, HV; Snoep, JL, Eur J Pharm Sci. (July, 2012) 46 vol. (4); pp. 233-243

Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation., June, 2012
Hines, HM; Papa, R; Ruiz, M; Papanicolaou, A; Wang, C; Nijhout, HF; McMillan, WO; Reed, RD, BMC Genomics. (June, 2012) 13 pp. 288

Mathematical model gives insights into vitamin B6 and kynurenine metabolism, 4, 2012
Rios-Avila, L; Nijhout, HF; Reed, MC; Sitren, HS; Gregory, JF, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26

Physiological response to homocysteine stress in Escherichia coli, 4, 2012
Jalli, IS; Nijhout, HF, Integrative and Comparative Biology (BioOne). 52 pp. E269-E269

Phenotypic Plasticity and Allometry: New Models and Evolutionary Implications, 4, 2012
Nijhout, HF, Integrative and Comparative Biology (BioOne). 52 pp. E129-E129

The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model., December, 2012
Ben-Shachar, R; Chen, Y; Luo, S; Hartman, C; Reed, M; Nijhout, HF, Theoretical Biology and Medical Modelling. (December, 2012) 9 pp. 55

An eco-physiological model of the impact of temperature on Aedes aegypti life history traits., December, 2012
Padmanabha, H; Correa, F; Legros, M; Nijhout, HF; Lord, C; Lounibos, LP, J Insect Physiol. (December, 2012) 58 vol. (12); pp. 1597-1608

Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model., October, 2012
Obeid, R; Hartmuth, K; Herrmann, W; Gortner, L; Rohrer, TR; Geisel, J; Reed, MC; Nijhout, HF, Mol Nutr Food Res. (October, 2012) 56 vol. (10); pp. 1582-1589

Mathematical insights into the effects of levodopa., July, 2012
Reed, MC; Nijhout, HF; Best, JA, Front Integr Neurosci. (July, 2012) 6 pp. 21

Supply-side constraints are insufficient to explain the ontogenetic scaling of metabolic rate in the tobacco Hornworm, Manduca sexta., September, 2012
Callier, V; Nijhout, HF, PLoS One. (September, 2012) 7 vol. (9); pp. e45455

Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers., July, 2011
Neuhouser, ML; Nijhout, HF; Gregory, JF; Reed, MC; James, SJ; Liu, A; Shane, B; Ulrich, CM, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. (July, 2011) 20 vol. (9); pp. 1912-1917

The role of developmental plasticity in evolutionary innovation., July, 2011
Moczek, AP; Sultan, S; Foster, S; Ledón-Rettig, C; Dworkin, I; Nijhout, HF; Abouheif, E; Pfennig, DW, Proceedings of the Royal Society of London: Biological Sciences. (July, 2011) 278 vol. (1719); pp. 2705-2713

Mathematical model insights into arsenic detoxification., August 1, 2011
Lawley, SD; Cinderella, M; Hall, MN; Gamble, MV; Nijhout, HF; Reed, MC, Theoretical Biology and Medical Modelling. (August 1, 2011) 8 pp. 31

optix drives the repeated convergent evolution of butterfly wing pattern mimicry., August 30, 2011
Reed, RD; Papa, R; Martin, A; Hines, HM; Counterman, BA; Pardo-Diaz, C; Jiggins, CD; Chamberlain, NL; Kronforst, MR; Chen, R; Halder, G; Nijhout, HF; McMillan, WO, Science. (August 30, 2011) 333 vol. (6046); pp. 1137-1141

Control of body size by oxygen supply reveals size-dependent and size-independent mechanisms of molting and metamorphosis., 8, 2011
Callier, V; Nijhout, HF, Proceedings of the National Academy of Sciences of USA. 108 vol. (35); pp. 14664-14669

Bursts and the efficacy of selective serotonin reuptake inhibitors., May, 2011
Best, J; Nijhout, HF; Reed, M, Pharmacopsychiatry. (May, 2011) 44 Suppl 1 pp. S76-S83

Respiratory physiology and the initiation of molting in the tobacco hornworm, Manduca sexta, 3, 2011
Callier, V; Nijhout, HF, Integrative and Comparative Biology (BioOne). 51 pp. E20-E20

Stabilization of Escherichia coli Methionine Cycle Upon Simulated Insertion of Arabidopsis Thaliana MMT Enzyme, 3, 2011
Jalli, IS; Nijhout, HF, Integrative and Comparative Biology (BioOne). 51 pp. E206-E206

Dependence of morphometric allometries on the growth kinetics of body parts., August 15, 2011
Nijhout, HF, Journal of Theoretical Biology. (August 15, 2011) 288 pp. 35-43

Mathematical model insights into arsenic detoxification., 0, 2011
Lawley, SD; Cinderella, M; Hall, MN; Gamble, MV; Nijhout, HF; Reed, MC, Theoretical Biology and Medical Modelling. 8 pp. 31-

Serotonin synthesis, release and reuptake in terminals: a mathematical model., August, 2010
Best, J; Nijhout, HF; Reed, M, Theoretical Biology and Medical Modelling. (August, 2010) 7 pp. 34

Models of dopaminergic and serotonergic signaling., May, 2010
Best, J; Reed, M; Nijhout, HF, Pharmacopsychiatry. (May, 2010) 43 Suppl 1 pp. S61-S66

The biological significance of substrate inhibition: a mechanism with diverse functions., May, 2010
Reed, MC; Lieb, A; Nijhout, HF, Bioessays. (May, 2010) 32 vol. (5); pp. 422-429

Photoperiodism in Insects: Effects on Morphology, August, 2010
Frederik Nijhout, H, (August, 2010) pp. 318-341

Mathematical model gives insights into vitamin B6 and kynurenine metabolism, 4, 2010
Rios-Avila, L; Nijhout, HF; Reed, MC; Sitren, HS; Gregory, JF, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24

Conflicting processes in the evolution of body size and development time., February, 2010
Nijhout, HF; Roff, DA; Davidowitz, G, Philosophical Transactions B. (February, 2010) 365 vol. (1540); pp. 567-575

The cellular and physiological mechanism of wing-body scaling in Manduca sexta., December, 2010
Nijhout, HF; Grunert, LW, Science. (December, 2010) 330 vol. (6011); pp. 1693-1695

Developmental constraints on the evolution of wing-body allometry in Manduca sexta, November, 2010
Tobler, A; Nijhout, HF, Evolution & Development. (November, 2010) 12 vol. (6); pp. 57-66

Developmental constraints on the evolution of wing-body allometry in Manduca sexta., 11, 2010
Tobler, A; Nijhout, HF, Evolution and Development. 12 vol. (6); pp. 592-600

A switch in the control of growth of the wing imaginal disks of Manduca sexta, May, 2010
Tobler, A; Nijhout, HF, PloS one. (May, 2010) 5 vol. (5); pp. e10723

Molecular and Physiological Basis of Colour Pattern Formation, August, 2010
Nijhout, HF, Advances in insect physiology. (August, 2010) 38 pp. 219-265

Evolutionary divergence of field and laboratory populations of Manduca sexta in response to host-plant quality, April, 2010
Diamond, SE; Hawkins, SD; Nijhout, HF; Kingsolver, JG, Ecological Entomology. (April, 2010) 35 vol. (2); pp. 166-174

Homeostatic mechanisms in dopamine synthesis and release: a mathematical model., 9, 2009
Best, JA; Nijhout, HF; Reed, MC, Theoretical Biology and Medical Modelling. 6 pp. 21

A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism., 4, 2009
Nijhout, HF; Gregory, JF; Fitzpatrick, C; Cho, E; Lamers, KY; Ulrich, CM; Reed, MC, The Journal of nutrition. 139 vol. (4); pp. 784-791

The importance of threshold size for the initiation of metamorphosis in the insect Tribolium castaneum, 2, 2009
Preuss, KM; Nijhout, HF, Integrative and Comparative Biology (BioOne). 49 pp. E291-E291

Partial co-option of the appendage patterning pathway in the development of abdominal appendages in the sepsid fly Themira biloba., January, 2010
Bowsher, JH; Nijhout, HF, Development Genes and Evolution. (January, 2010) 219 vol. (11-12); pp. 577-587

Singularity in polarization: rewiring yeast cells to make two buds., 11, 2009
Howell, AS; Savage, NS; Johnson, SA; Bose, I; Wagner, AW; Zyla, TR; Nijhout, HF; Reed, MC; Goryachev, AB; Lew, DJ, Cell. 139 vol. (4); pp. 731-743

Passive and active stabilization of dopamine in the striatum, 0, 2009
Reed, MC; Best, J; Nijhout, HF, Bioscience Hypotheses. 2 vol. (4); pp. 240-244

Environment and genetic accommodation., 0, 2009
Nijhout, HF; Suzuki, Y, Biological Theory. 3 vol. (1-9);

Use of pathway information in molecular epidemiology., December, 2009
Thomas, DC; Conti, DV; Baurley, J; Nijhout, F; Reed, M; Ulrich, CM, Human genomics. (December, 2009) 4 vol. (1); pp. 21-42

Mathematical models of one-carbon metabolism, September, 2008
Nijhout, HF; Reed, M; Ulrich, C, Vitamins and Hormones. (September, 2008) 79 pp. 45-82

Modeling folate, one-carbon metabolism, and DNA methylation., August, 2008
Ulrich, CM; Reed, MC; Nijhout, HF, Nutrition Reviews. (August, 2008) 66 Suppl 1 pp. S27-S30

Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis., July, 2008
Ulrich, CM; Neuhouser, M; Liu, AY; Boynton, A; Gregory, JF; Shane, B; James, SJ; Reed, MC; Nijhout, HF, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. (July, 2008) 17 vol. (7); pp. 1822-1831

A mathematical model of glutathione metabolism., July, 2008
Reed, MC; Thomas, RL; Pavisic, J; James, SJ; Ulrich, CM; Nijhout, HF, Theoretical Biology and Medical Modelling. (July, 2008) 5 vol. (8); pp. 8

Using in silico priors for pathway modeling, 11, 2008
Conti, DV; Figueiredo, JC; Levine, AJ; Ulrich, CM; Poynter, JN; Nijhout, HF; Reed, M; Zheng, Y; Haile, RW, Genetic Epidemiology. 32 vol. (7); pp. 669-669

Constraint and developmental dissociation of phenotypic integration in a genetically accommodated trait., November, 2008
Suzuki, Y; Nijhout, HF, Evolution and Development. (November, 2008) 10 vol. (6); pp. 690-699

Size matters (but so does time), and it's OK to be different., October, 2008
Nijhout, HF, Developmental Cell. (October, 2008) 15 vol. (4); pp. 491-492

A mathematical model for the regulation of juvenile hormone titers., 1, 2008
Nijhout, HF; Reed, MC, Journal of Insect Physiology. 54 vol. (1); pp. 255-264

Genetic basis of adaptive evolution of a polyphenism by genetic accommodation., 1, 2008
Suzuki, Y; Nijhout, HF, Journal of Evolutionary Biology. 21 vol. (1); pp. 57-66

Genetic basis of adaptive evolution of a polyphenism by genetic accommodation, January, 2008
Suzuki Y, Nijhout HF, Journal of Evolutionary Biology. (January, 2008) 21 pp. 57-66

A mathematical model for the regulation of juvenile hormone titers, January, 2008
Nijhout HF, Reed MC, J. Insect Physiology. (January, 2008) 54 pp. 255-264

Mathematical models of folate-mediated one-carbon metabolism., 0, 2008
Nijhout, HF; Reed, MC; Ulrich, CM, Vitamins and hormones. 79 pp. 45-82

Developmental phenotypic landscapes, June, 2008
Nijhout, HF, Evolutionary Biology. (June, 2008) 35 vol. (2); pp. 100-103

Propagation of fluctuations in biochemical systems, I: Linear SSC networks, 8, 2007
Anderson, DF; Mattingly, JC; Nijhout, HF; Reed, MC, Bulletin of Mathematical Biology. 69 vol. (6); pp. 1791-1813

Evolution of novel abdominal appendages in a sepsid fly from histoblasts, not imaginal discs., 7, 2007
Bowsher, JH; Nijhout, HF, Evolution and Development. 9 vol. (4); pp. 347-354

Size and shape: the developmental regulation of static allometry in insects., 6, 2007
Shingleton, AW; Frankino, WA; Flatt, T; Nijhout, HF; Emlen, DJ, Bioessays. 29 vol. (6); pp. 536-548

The control of growth and differentiation of the wing imaginal disks of Manduca sexta., 2, 2007
Nijhout, HF; Smith, WA; Schachar, I; Subramanian, S; Tobler, A; Grunert, LW, Developmental Biology. 302 vol. (2); pp. 569-576

Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria., 12, 2007
Leduc, D; Escartin, F; Nijhout, HF; Reed, MC; Liebl, U; Skouloubris, S; Myllykallio, H, Journal of bacteriology. 189 vol. (23); pp. 8537-8545

Cryptic variation in butterfly eyespot development: the importance of sample size in gene expression studies, 0, 2007
Reed, RD; Chen, P-H; Nijhout, HF, Evolution and Development. 9 vol. (1); pp. 2-9

A day in the life of cell metabolism., 0, 2007
Nijhout, HF; Reed, MC; Ulrich, CM, Biological Theory (in press).

The empirical non-equivalence of genic and genotypic models of selection: A decisive refutation of genic selectionism and pluralistic genic selectionism., 0, 2007
Brandon, R.N. and Nijhout, H.F., Philosophy of Science. 73 pp. 277-297

Mathematical modeling: epidemiology meets systems biology., 5, 2006
Ulrich, CM; Nijhout, HF; Reed, MC, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 15 vol. (5); pp. 827-829

Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate., 4, 2006
Nijhout, HF; Reed, MC; Anderson, DF; Mattingly, JC; James, SJ; Ulrich, CM, Epigenetics : official journal of the DNA Methylation Society. 1 vol. (2); pp. 81-87

The robustness of the transcriptional response to alterations in morphogenetic gradients., 3, 2006
Veitia, RA; Nijhout, HF, Bioessays. 28 vol. (3); pp. 282-289

Evolution of a polyphenism by genetic accommodation., 2, 2006
Suzuki, Y; Nijhout, HF, Science. 311 vol. (5761); pp. 650-652

In silico experimentation with a model of hepatic mitochondrial folate metabolism., 12, 2006
Nijhout, HF; Reed, MC; Lam, S-L; Shane, B; Gregory, JF; Ulrich, CM, Theoretical Biology and Medical Modelling. 3 pp. 40

A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism., 10, 2006
Reed, MC; Nijhout, HF; Neuhouser, ML; Gregory, JF; Shane, B; James, SJ; Boynton, A; Ulrich, CM, The Journal of nutrition. 136 vol. (10); pp. 2653-2661

Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions., 10, 2006
Boyles, AL; Billups, AV; Deak, KL; Siegel, DG; Mehltretter, L; Slifer, SH; Bassuk, AG; Kessler, JA; Reed, MC; Nijhout, HF; George, TM; Enterline, DS; Gilbert, JR; Speer, MC; NTD Collaborative Group, , Environmental health perspectives. 114 vol. (10); pp. 1547-1552

Stochastic gene expression: dominance, thresholds and boundaries., 2006
H.F. Nijhout, (2006) pp. 61-75

Long-Range Allosteric Interactions between the Folate and Methionine Cycles Stabilize DNA Methylation Reaction Rate (vol 2, pg 81, 2006), 0, 2006
Nijhout, HF; Reed, MC; Anderson, DF; Mattingly, JC; James, SJ; Ulrich, CM, Epigenetics : official journal of the DNA Methylation Society. 1 vol. (3); pp. 115-115

The empirical nonequivalence of genie and genotypic models of selection: A (Decisive) refutation of genie selectionism and pluralistic genie selectionism, 0, 2006
Brandon, RN; Nijhout, HF, Philosophy of Science. 73 vol. (3); pp. 277-297

A quantitative analysis of the mechanism that controls body size in Manduca sexta., 0, 2006
Nijhout, HF; Davidowitz, G; Roff, DA, Journal of Biology. 5 vol. (5); pp. 16

A physiological perspective on the response of body size and development time to simultaneous directional selection., 6, 2005
Davidowitz, G; Roff, DA; Nijhout, HF, Integrative and Comparative Biology (BioOne). 45 vol. (3); pp. 525-531

The physiological regulation of simultaneously selected life history traits, 12, 2005
Davidowitz, G; Roff, DA; Nijhout, HF, Integrative and Comparative Biology (BioOne). 45 vol. (6); pp. 984-984

Geographic variation of caste structure among ant populations., 3, 2004
Yang, AS; Martin, CH; Nijhout, HF, Current Biology. 14 vol. (6); pp. 514-519

Trade-offs during the development of primary and secondary sexual traits in a horned beetle., 2, 2004
Moczek, AP; Nijhout, HF, American Naturalist. 163 vol. (2); pp. 184-191

Neuroendocrine regulation of hair development in the ventral hind wing of Precis coenia, 12, 2004
Yamanaka, A; Nijhout, HF; Grunert, LW; Suzuki, Y; Kitazawa, C; Endo, K, Zoological Science. 21 vol. (12); pp. 1338-1338

The physiological basis of reaction norms: the interaction among growth rate, the duration of growth and body size., 2004
Davidowitz, G; Nijhout, HF, Integrative and Comparative Biology (BioOne). (2004) 44 vol. (6); pp. 443-449

A mathematical model of the folate cycle: new insights into folate homeostasis., 12, 2004
Nijhout, HF; Reed, MC; Budu, P; Ulrich, CM, The Journal of biological chemistry. 279 vol. (53); pp. 55008-55016

The effects of environmental variation on a mechanism that controls insect body size, 1, 2004
Davidowitz, G; D'Amico, LJ; Nijhout, HF, Evolutionary ecology research. 6 vol. (1); pp. 49-62

A mathematical model of the methionine cycle., 2004
Reed, MC; Nijhout, HF; Sparks, R; Ulrich, CM, Journal of Theoretical Biology. (2004) 226 vol. (1); pp. 33-43

Growth and cell cycle control in Drosophila, 0, 2004
B.A.Edgar and H.F. Nijhout, pp. 23-83

The control of body size in insects., 9, 2003
Nijhout, HF, Developmental Biology. 261 vol. (1); pp. 1-9

Pigmentation pattern formation in butterflies: experiments and models., 8, 2003
Nijhout, HF; Maini, PK; Madzvamuse, A; Wathen, AJ; Sekimura, T, Comptes Rendus Biologies. 326 vol. (8); pp. 717-727

Rapid evolution of a polyphenic threshold., 5, 2003
Moczek, AP; Nijhout, HF, Evolution and Development. 5 vol. (3); pp. 259-268

A mechanistic study of evolvability using the mitogen-activated protein kinase cascade., 5, 2003
Nijhout, HF; Berg, AM; Gibson, WT, Evolution and Development. 5 vol. (3); pp. 281-294

Critical weight in the development of insect body size., 3, 2003
Davidowitz, G; D'Amico, LJ; Nijhout, HF, Evolution and Development. 5 vol. (2); pp. 188-197

The physiological basis of reaction norms: Where developmental rate and duration of development connect, 12, 2003
Davidowitz, G; Nijhout, HF, Integrative and Comparative Biology (BioOne). 43 vol. (6); pp. 841-841

The physiological regulation of the response to simultaneous selection on body size and development time in Manduca sexta, 12, 2003
Davidowitz, G; Roff, DA; Nijhout, HF, Integrative and Comparative Biology (BioOne). 43 vol. (6); pp. 974-974

The control of growth., 12, 2003
Nijhout, HF, Development (Cambridge). 130 vol. (24); pp. 5863-5867

Polymorphic mimicry in Papilio dardanus: mosaic dominance, big effects, and origins., 11, 2003
Nijhout, HF, Evolution and Development. 5 vol. (6); pp. 579-592

On the association between genes and complex traits., 10, 2003
Nijhout, HF, Journal of Investigative Dermatology Symposium Proceedings. 8 vol. (2); pp. 162-163

A perspective for understanding the modes of juvenile hormone action as a lipid signaling system., 10, 2003
Wheeler, DE; Nijhout, HF, Bioessays. 25 vol. (10); pp. 994-1001

Development and evolution of adaptive polyphenisms., 1, 2003
Nijhout, HF, Evolution and Development. 5 vol. (1); pp. 9-18

Gradients, diffusion, and genes in pattern formation, 0, 2003
Nijhout, HF, ORIGINATION OF ORGANISMAL FORM. pp. 165-181

The importance of context in genetics - Genetic effects can be altered by their surroundings, and this determines the inheritance of traits such as flower color and the likelihood of cancer, 0, 2003
Nijhout, HF, American scientist. 91 vol. (5); pp. 416-423

Developmental perspectives on phenotypic plasticity, canalization, and fluctuating asymmetry., 0, 2003
Nijhout, H.F. and G. Davidowitz., pp. 3-13

Developmental mechanisms of threshold evolution in a polyphenic beetle., 2002
Moczek, AP; Nijhout, HF, Evolution and Development. (2002) 4 vol. (4); pp. 252-264

The nature of robustness in development., 6, 2002
Nijhout, HF, Bioessays. 24 vol. (6); pp. 553-563

The physiological regulation of insect body size., 12, 2002
Davidowitz, G; D'Amico, LJ; Roff, DA; Nijhout, HF, Integrative and Comparative Biology (BioOne). 42 vol. (6); pp. 1217-1217

Bombyxin is a growth factor for wing imaginal disks in Lepidoptera., 11, 2002
Nijhout, HF; Grunert, LW, Proceedings of the National Academy of Sciences of USA. 99 vol. (24); pp. 15446-15450

Genetic regulatory networks., 0, 2002
H.F. Nijhout,

Developmental perspectives on phenotypic plasticity, canalization, and fluctuating asymmetry., 0, 2002
Nijhout, H.F. and G. Davidowitz.,

A method for sexing final instar larvae of the genus Onthophagus Latreille (Coleoptera: Scarabaeidae), 0, 2002
Moczek, AP; Nijhout, HF, Coleopterists Bulletin. 56 vol. (2); pp. 279-284

The role of wing veins in colour pattern development in the butterfly Papilio xuthus (Lepidoptera: Papilionidae), 0, 2002
Koch, PB; Nijhout, HF, European journal of entomology. 99 vol. (1); pp. 67-72

Hormonal control of male horn length dimorphism in Onthophagus taurus (Coleoptera: Scarabaeidae): a second critical period of sensitivity to juvenile hormone., 9, 2001
Emlen, DJ; Nijhout, HF, Journal of Insect Physiology. 47 vol. (9); pp. 1045-1054

Nonlinear developmental processes as sources of dominance., 9, 2001
Gilchrist, MA; Nijhout, HF, Genetics. 159 vol. (1); pp. 423-432

The developmental and physiological basis of body size evolution in an insect., 8, 2001
D'Amico, LJ; Davidowitz, G; Nijhout, HF, Proceedings of the Royal Society of London: Biological Sciences. 268 vol. (1476); pp. 1589-1593

How is an insect the size that it is? How do physiological mechanisms change to produce genetic, environmental, and plasticity effects on body size?, 12, 2001
Davidowitz, G; Nijhout, HF; D'Amico, LJ, Integrative and Comparative Biology. 41 vol. (6); pp. 1423-1423

Insect polyphenisms and adaptation., 12, 2001
Nijhout, HF, Integrative and Comparative Biology. 41 vol. (6); pp. 1540-1540

Elements of butterfly wing patterns., 10, 2001
Nijhout, HF, Journal of Experimental Zoology. 291 vol. (3); pp. 213-225

The ontogeny of phenotypes, 0, 2001
H.F. Nijhout,

Origin of butterfly wing patterns, 0, 2001
H.F. Nijhout,

The role of low levels of juvenile hormone esterase in the metamorphosis of Manduca sexta, 0, 2001
Browder, MH; D'Amico, LJ; Nijhout, HF, Journal of Insect Science. 1 vol. (11); pp. 1-4

Food availability controls the onset of metamorphosis in the dung beetle Onthophagus taurus (Coleoptera: Scarabaeidae), 0, 2001
Shafiei, M; Moczek, AP; Nijhout, HF, Physiological Entomology. 26 vol. (2); pp. 173-180

The role of low levels of juvenile hormone esterase in the metamorphosis of Manduca sexta., 0, 2001
Browder, MH; D'Amico, LJ; Nijhout, HF, Journal of Insect Science. 1 pp. 11

Control of growth and differentiation of the wing imaginal disk of Precis coenia (Lepidoptera : Nymphalidae), 3, 2000
Miner, AL; Rosenberg, AJ; Nijhout, HF, Journal of Insect Physiology. 46 vol. (3); pp. 251-258

Body size evolution in a laboratory strain of Manduca sexta: implications for studies in insect physiology and endocrinology., 12, 2000
D'Amico, LJ; Davidowitz, G; Nijhout, HF, Integrative and Comparative Biology. 40 vol. (6); pp. 988-989

The development and evolution of exaggerated morphologies in insects., 0, 2000
Emlen, DJ; Nijhout, HF, Annual Review of Entomology. 45 pp. 661-708

The effect of environmental conditions on mating activity of the Buckeye butterfly, Precis coenia, 0, 2000
McDonald, AK; Nijhout, HF, J. Res. Lepidopt.. 35 vol. (22-28);

When developmental pathways diverge., 5, 1999
Nijhout, HF, Proceedings of the National Academy of Sciences of USA. 96 vol. (10); pp. 5348-5350

Ultrabithorax function in butterfly wings and the evolution of insect wing patterns., 2, 1999
Weatherbee, SD; Nijhout, HF; Grunert, LW; Halder, G; Galant, R; Selegue, J; Carroll, S, Current Biology. 9 vol. (3); pp. 109-115

Hormonal control of male horn length dimorphism in the dung beetle Onthophagus taurus (Coleoptera: Scarabaeidae)., 1, 1999
Emlen, DJ; Nijhout, HF, Journal of Insect Physiology. 45 vol. (1); pp. 45-53

Population genetics and microevolution developmental mechanisms., 0, 1999
Nijhout, HF, Integrative and Comparative Biology. 39 vol. (5); pp. 14A-14A

The evolution of polyphenic development and its consequences: Rapid allometric divergence between exotic populations of the scarab beetle Onthophagus taurus., 0, 1999
Moczek, AP; Nijhout, HF, Integrative and Comparative Biology. 39 vol. (5); pp. 12A-12A

Control mechanisms of polyphenic development in insects, 0, 1999
NIJHOUT, HF, BioScience. 49 pp. 181-192

Control mechanisms of polyphenic development in insects: In polyphenic development, environmental factors alter some aspects of development in an orderly and predictable way, 0, 1999
Nijhout, HF, BioScience. 49 vol. (3); pp. 181-192

Uitrabithorax function in butterfly wings and the evolution of insect wing patterns, 0, 1999
Weatherbee, SD; Nijhout, HF; Grunert, LW; Halder, G; Galant, R; Selegue, J; Carroll, S, Current Biology. 9 vol. (3); pp. 109-115

Genetics of fluctuating asymmetry: A developmental model of developmental instability, 0, 1999
Klingenberg, CP; Nijhout, HF, Evolution. 53 vol. (2); pp. 358-375

Homeosis in a butterfly wing, 6, 1998
Weatherbee, SD; Halder, G; Galant, R; Selegue, J; Nijhout, HF; Carroll, S, Developmental Biology. 198 vol. (1); pp. 199-199

Control of pupal commitment in the imaginal disks of Precis coenia (Lepidoptera: Nymphalidae)., 3, 1998
Nijhout, HF; Kremen, C, Journal of Insect Physiology. 44 vol. (3-4); pp. 287-296

Competition among body parts in the development and evolution of insect morphology., 3, 1998
Nijhout, HF; Emlen, DJ, Proceedings of the National Academy of Sciences of USA. 95 vol. (7); pp. 3685-3689

Competition among body parts in the development and evolution of insect morphology, 0, 1998
Nijhout, HF; Emlen, DJ, Proceedings of the National Academy of Sciences of USA. 95 vol. (7); pp. 3685-3689

Competition among growing organs and developmental control of morphological asymmetry, 0, 1998
Klingenberg, CP; Nijhout, HF, Proceedings of the Royal Society of London: Biological Sciences. 265 vol. (1401); pp. 1135-1139

Growth models of complex allometries in holometabolous insects (vol 148, pg 40, 1996), 3, 1997
Nijhout, HF; Wheeler, DE, American Naturalist. 149 vol. (3); pp. 606-606

Developmental models and polygenic characters, 0, 1997
Nijhout, HF; Paulsen, SM, American Naturalist. 149 vol. (2); pp. 394-405

Ommochrome Pigmentation of the linea and rosa Seasonal Forms of Precis coenia (Lepidoptera: Nymphalidae), 0, 1997
Nijhout, HF, Archives of Insect Biochemistry and Physiology. 36 vol. (3); pp. 215-222

Focus on butterfly eyespot development., 11, 1996
Nijhout, HF, Nature. 384 vol. (6606); pp. 209-210

Growth models of complex allometries in holometabolous insects, 0, 1996
Nijhout, HF; Wheeler, DE, American Naturalist. 148 vol. (1); pp. 40-56

Hormonal control of a seasonal polyphenism in Precis coenia (Lepidoptera: Nymphalidae), 0, 1995
Rountree, DB; Nijhout, HF, Journal of Insect Physiology. 41 vol. (11); pp. 987-992

Pattern induction across a homeotic boundary in the wings of Precis coenia (Hbn.) (Lepidoptera: Nymphalidae), 0, 1995
Nijhout, HF; Rountree, DB, International Journal of Insect Morphology and Embryology. 24 vol. (3); pp. 243-251

Genetic control of a seasonal morph in Precis coenia (Lepidoptera: Nymphalidae), 0, 1995
Rountree, DB; Nijhout, HF, Journal of Insect Physiology. 41 vol. (12); pp. 1141-1145

Genes on the wing., 7, 1994
Nijhout, HF, Science. 265 vol. (5168); pp. 44-45

DEVELOPMENTAL PERSPECTIVES ON EVOLUTION OF BUTTERFLY MIMICRY, 3, 1994
NIJHOUT, HF, BioScience (BioOne). 44 vol. (3); pp. 148-157

Symmetry systems and compartments in Lepidopteran wings: The evolution of a patterning mechanism, 0, 1994
Nijhout, HF, Development. 120 vol. (SUPPL.); pp. 225-233

Developmental perspectives on evolution of butterfly mimicry. Recent insights into development of color patterns have led to a simpler, more complete view of butterfly genetics, 0, 1994
Nijhout, HF, BioScience. 44 vol. (3); pp. 148-157

PHENOTYPIC CORRELATION STRUCTURE AMONG ELEMENTS OF THE COLOR PATTERN IN PRECIS-COENIA (LEPIDOPTERA, NYMPHALIDAE), 4, 1993
PAULSEN, SM; NIJHOUT, HF, Evolution. 47 vol. (2); pp. 593-618

PATTERN-FORMATION IN BIOLOGICAL-SYSTEMS, 0, 1992
NIJHOUT, HF, 1991 LECTURES IN COMPLEX SYSTEMS. 4 pp. 159-187

PHENOTYPIC CORRELATIONS AMONG ELEMENTS OF THE COLOR PATTERN IN PRECIS-COENIA (LEPIDOPTERA, NYMPHALIDAE), 0, 1991
PAULSEN, SM; NIJHOUT, HF, Integrative and Comparative Biology. 31 vol. (5); pp. A49-A49

ITERATION AND SYMMETRY, 0, 1991
NIJHOUT, HF, SAQ: The South Atlantic Quarterly. 90 vol. (1); pp. 61-86

Metaphors and the role of genes in development., 9, 1990
Nijhout, HF, Bioessays. 12 vol. (9); pp. 441-446

A comprehensive model for colour pattern formation in butterflies, 0, 1990
Nijhout, HF, Proceedings of the Royal Society of London: Biological Sciences. 239 vol. (1294); pp. 81-113

An analysis of the phenotypic effects of certain colour pattern genes in Heliconius (Lepidoptera: Nymphalidae), 0, 1990
Nijhout, HF; Wray, GA; Gilbert, LE, Biological Journal of the Linnean Society. 40 vol. (4); pp. 357-372

Color pattern specific proteins in black scales in developing wings of Precis coenia Hübner (Nymphalidae, Lepidoptera), 0, 1990
Koch, PB; Nijhout, HF, Roux's archives of developmental biology : the official organ of the EDBO. 199 vol. (5); pp. 289-294

Juvenile hormone controls the onset of pupal commitment in the imaginal disks and epidermis of Precis coenia (Lepidoptera: Nymphalidae), 0, 1989
Kremen, C; Nijhout, HF, Journal of Insect Physiology. 35 vol. (8); pp. 603-612

INSECT MORPHOGENESIS - SCHWALM,FE, 8, 1988
NIJHOUT, HF, Nature. 334 vol. (6184); pp. 660-660

Colour pattern regulation after surgery on the wing disks of Precis coenia (Lepidoptera: Nymphalidae), 0, 1988
Nijhout, HF; Grunert, LW, Development. 102 vol. (2); pp. 377-385

Homologies in the colour patterns of the genus Heliconius (Lepidoptera: Nymphalidae), 0, 1988
Nijhout, HF; Wray, GA, Biological Journal of the Linnean Society. 33 vol. (4); pp. 345-365

PATTERN AND PATTERN DIVERSITY ON LEPIDOPTERAN WINGS, 9, 1986
NIJHOUT, HF, BioScience (BioOne). 36 vol. (8); pp. 527-533

ONTOGENY, PHYLOGENY AND EVOLUTION OF FORM - AN ALGORITHMIC APPROACH, 12, 1986
NIJHOUT, HF; WRAY, GA; KREMEN, C; TERAGAWA, CK, Systematic Zoology. 35 vol. (4); pp. 445-457

Homologies in the colour patterns of the genus Charaxes (Lepidoptera: Nymphalidae), 0, 1986
Nijhout, HF; Wray, GA, Biological Journal of the Linnean Society. 28 vol. (4); pp. 387-410

Cautery-induced colour patterns in Precis coenia (Lepidoptera: Nymphalidae)., 4, 1985
Nijhout, HF, Journal of Embryology and Experimental Morphology. 86 pp. 191-203

Independent development of homologous pattern elements in the wing patterns of butterflies., 3, 1985
Nijhout, HF, Developmental Biology. 108 vol. (1); pp. 146-151

DEFINING COMMITMENT AND COMPETENCE IN LEPIDOPTERAN IMAGINAL DISKS BY HORMONAL TREATMENT, 0, 1985
KREMEN, C; NIJHOUT, HF, Integrative and Comparative Biology. 25 vol. (4); pp. A62-A62

The Developmental Physiology of Color Patterns in Lepidoptera, 0, 1985
Nijhout, HF, Advances in insect physiology. 18 vol. (C); pp. 181-247

Colour pattern modification by coldshock in Lepidoptera., 6, 1984
Nijhout, HF, Journal of Embryology and Experimental Morphology. 81 pp. 287-305

SOLDIER DETERMINATION IN PHEIDOLE-BICARINATA - INHIBITION BY ADULT SOLDIERS, 0, 1984
WHEELER, DE; NIJHOUT, HF, Journal of Insect Physiology. 30 vol. (2); pp. 127-135

Abdominal stretch reception in Dipetalogaster maximus (Hemiptera: Reduviidae), 0, 1984
Nijhout, HF, Journal of Insect Physiology. 30 vol. (8); pp. 629-633

In vitro stimulation of cell death in the moulting glands of Oncopeltus fasciatus by 20-hydroxyecdysone, 0, 1983
Smith, WA; Nijhout, HF, Journal of Insect Physiology. 29 vol. (2); pp. 169-176

Definition of a juvenile hormone-sensitive period in Rhodnius prolixus, 0, 1983
Nijhout, HF, Journal of Insect Physiology. 29 vol. (9); pp. 669-677

SOLDIER DETERMINATION IN PHEIDOLE-BICARIN AT A - EFFECT OF METHOPRENE ON CASTE AND SIZE WITHIN CASTES, 0, 1983
WHEELER, DE; NIJHOUT, HF, Journal of Insect Physiology. 29 vol. (11); pp. 847-854

Definition of a juvenile hormone-sensitive period in Rhodnius prolixus, 0, 1983
NIJHOUT, H, Journal of Insect Physiology. 219 pp. 669-677

SYNCHRONY OF JUVENILE HORMONE-SENSITIVE PERIODS FOR INTERNAL AND EXTERNAL DEVELOPMENT IN LAST-INSTAR LARVAE OF ONCOPELTUS-FASCIATUS, 0, 1982
SMITH, WA; NIJHOUT, HF, Journal of Insect Physiology. 28 vol. (9); pp. 797-&

Ultrastructural changes accompanying secretion and cell death in the molting glands of an insect (Oncopeltus)., 0, 1982
Smith, WA; Nijhout, HF, Tissue and Cell. 14 vol. (2); pp. 243-252

Juvenile hormone and the physiological basis of insect polymorphisms., 0, 1982
Nijhout, HF; Wheeler, DE, Quarterly Review of Biology. 57 vol. (2); pp. 109-133

Soldier determination in ants: new role for juvenile hormone., 7, 1981
Wheeler, DE; Nijhout, HF, Science. 213 vol. (4505); pp. 361-363

SOLDIER DETERMINATION IN THE ANT PHEIDOLE-BICARINATA - EFFECTS OF A JUVENILE-HORMONE ANALOG ON CASTE AND SIZE WITHIN CASTES, 0, 1981
WHEELER, DE; NIJHOUT, HF, Integrative and Comparative Biology. 21 vol. (4); pp. 1028-1028

Physiological control of molting in insects, 0, 1981
Nijhout, HF, Integrative and Comparative Biology (BioOne). 21 vol. (3); pp. 631-640

Imaginal wing discs in larvae of the soldier caste of Pheidole bicarinata vinelandica Forel (Hymenoptera : Formicidae), 0, 1981
Wheeler, DE; Nijhout, HF, International Journal of Insect Morphology and Embryology. 10 vol. (2); pp. 131-139

The color patterns of butterflies and moths, 0, 1981
Nijhout, HF, Scientific American. 245 vol. (5); pp. 140-150

Effects of a juvenile hormone analogue on the duration of the fifth instar in the milkweed bug Oncopeltus fasciatus, 0, 1981
Smith, WA; Nijhout, HF, Journal of Insect Physiology. 27 vol. (3); pp. 169-173

Ontogeny of the color pattern on the wings of Precis coenia (Lepidoptera: Nymphalidae)., 12, 1980
Nijhout, HF, Developmental Biology. 80 vol. (2); pp. 275-288

Pattern formation on lepidopteran wings: determination of an eyespot., 12, 1980
Nijhout, HF, Developmental Biology. 80 vol. (2); pp. 267-274

IMAGINAL WING DISKS IN WORKER LARVAE OF THE ANT, PHEIDOLE-BICARINATA-VINELANDICA, 0, 1980
WHEELER, DE; NIJHOUT, HF, Integrative and Comparative Biology. 20 vol. (4); pp. 878-878

JUVENILE-HORMONE REDUCES THE DURATION OF THE 5TH LARVAL INSTAR OF ONCOPELTUS-FASCIATUS, 0, 1980
SMITH, WA; NIJHOUT, HF, Integrative and Comparative Biology. 20 vol. (4); pp. 899-899

PHYSIOLOGICAL CONTROL OF PROTHORACICOTROPIC HORMONE-SECRETION, 0, 1980
NIJHOUT, HF, Integrative and Comparative Biology. 20 vol. (4); pp. 760-760

Antennal hair erection in male mosquitoes: a new mechanical effector in insects., 11, 1979
Nijhout, HF; Sheffield, HG, Science. 206 vol. (4418); pp. 595-596

REGULATION OF METAMORPHIC CELL-DEATH IN THE MOLTING GLANDS OF ONCOPELTUS-FASCIATUS, 0, 1979
SMITH, WA; NIJHOUT, HF, Integrative and Comparative Biology. 19 vol. (3); pp. 915-915

Stretch-induced moulting in Oncopeltus fasciatus, 0, 1979
Nijhout, HF, Journal of Insect Physiology. 25 vol. (3); pp. 277-281

STRETCH-INDUCED MOLTING IN ONCOPELTUS-FASCIATUS (HEMIPTERA LYGAEIDAE), 0, 1978
NIJHOUT, HF, Integrative and Comparative Biology. 18 vol. (3); pp. 625-625

WING PATTERN FORMATION IN LEPIDOPTERA - MODEL, 0, 1978
NIJHOUT, HF, Journal of Experimental Zoology. 206 vol. (2); pp. 119-136

Diuresis after a bloodmeal in female Anopheles freeborni, 0, 1978
Nijhout, HF; Carrow, GM, Journal of Insect Physiology. 24 vol. (4); pp. 293-298

Alpha-adrenergic activity of isoproterenol in mosquito antennae, 0, 1978
Nijhout, HF; Martin, SK, Experientia. 34 vol. (6); pp. 758-759

CONTROL OF ANTENNAL HAIR ERECTION IN MALE MOSQUITOS, 0, 1977
NIJHOUT, HF, Biological Bulletin. 153 vol. (3); pp. 591-603

The rôle of ecdysone in pupation of Manduca sexta, 0, 1976
Nijhout, HF, Journal of Insect Physiology. 22 vol. (3); pp. 453-463

ROLE OF ECDYSONE IN PUPATION OF MANDUCA-SEXTA, 0, 1976
NIJHOUT, HF, Journal of Insect Physiology. 22 vol. (3); pp. 453-&

A threshold size for metamorphosis in the tobacco hornworm, Manduca sexta (L.)., 8, 1975
Nijhout, HF, Biological Bulletin. 149 vol. (1); pp. 214-225

Excretory role of the midgut in larvae of the tobacco hornworm, Manduca sexta (L.)., 2, 1975
Nijhout, HF, The Journal of experimental biology. 62 vol. (1); pp. 221-230

Dynamics of juvenile hormone action in larvae of the tobacco hornworm, Manduca sexta (L.)., 12, 1975
Nijhout, HF, Biological Bulletin. 149 vol. (3); pp. 568-579

Permanent loss of male fecundity following sperm depletion in Aedes aegypti (L.)., 1, 1975
Hausermann, W; Nijhout, HF, Journal of Medical Entomology. 11 vol. (6); pp. 707-715

Axonal pathways in the brain-retrocerebral neuroendocrine complex of Manduca sexta (L.) (Lepidoptera: Sphingidae), 0, 1975
Nijhout, HF, International Journal of Insect Morphology and Embryology. 4 vol. (6); pp. 529-538

A threshold size for metamorphosis in the tobacco hornworm, Manduca sexta, 0, 1975
NIJHOUT, H, Biol. Bull.. 149 pp. 214-225

Control of moulting and metamorphosis in the tobacco hornworm, Manduca sexta (L.): cessation of juvenile hormone secretion as a trigger for pupation., 10, 1974
Nijhout, HF; Williams, CM, The Journal of experimental biology. 61 vol. (2); pp. 493-501

Control of moulting and metamorphosis in the tobacco hornworm, Manduca sexta (L.): growth of the last-instar larva and the decision to pupate., 10, 1974
Nijhout, HF; Williams, CM, The Journal of experimental biology. 61 vol. (2); pp. 481-491

Reproductive isolation in Stegomyia mosquitoes. III evidence for a sexual pheromone, 0, 1971
Nijhout, HF; Jr, GBC, Entomologia Experimentalis et Applicata. 14 vol. (4); pp. 399-412

Book Chapters:

Mathematical modeling of cell metabolism in Encyclopedia of Applied and Computational Mathematics, October, 2013
Reed MC, Kurtz T, Nijhout HF

Mathematical models: Interactions between serotonin and dopamine in Parkinson's Disease. in Etiology and Pathophysiology of Parkinson's Disease., August, 2011
Best J, Oakley G, Reed MC and Nijhout HF

Insect Hormones in , 0, 1998
Nijhout, HF

The development and evolution of butterfly wing patterns in , 0, 1991
Nijhout, HF

Awards

  • 2006 Founders' Memorial Award, Entomological Society of America

  • 2006 ESA Founders' Memorial Award, Entomological Society of America

  • 1997 University Scholar-Teacher Award, Duke University

  • 1989 Fellow, American Association for the Advancement of Science