Gustavo Monteiro Silva

Assistant Professor of Biology

Office: 
130 Science Drive, 3103 French Family Science Center, Durham, NC 27708
Campus Box: 
130 Science Drive, Box 90338, Durham, NC 27708
My main research goal is to understand and be able to control how cells respond to stressful and harmful conditions, which are the underlying causes of many human diseases. To achieve this goal, I study cellular response to stress at the protein level and aim to characterize the different regulatory functions mediated by the ubiquitin-proteasome system (UPS), essential machinery involved in modulating protein dynamics. Ultimately, regulating specific UPS roles will provide new tools to increase cellular tolerance to a variety of environmental stresses, which is highly relevant for a variety of degenerative diseases. The main focus of my lab is to investigate the unprecedented regulation of translation mediated by ubiquitin. I laid the groundwork for this research investigating the ubiquitination response in the budding yeast Saccharomyces cerevisiae and we will explore the evolutionary conservation of this pathway and its function in neuronal cells. Our lab is excited to keep pushing the field forward and to use a combination of proteomics, genomics, and molecular methods to understand the mechanisms by which ubiquitin regulates translation, and ultimately, cellular response to stress.

Education

  • Associate Research Scientist, Center For Genomics And Systems Biology, Department Of Biology, New York University 2011 - 2017

  • Ph.D., University of Sao Paulo (Brazil) 2010

  • Lic., University of Sao Paulo (Brazil) 2007

  • B.Sc., University of Sao Paulo (Brazil) 2004

Silva, GM, Wei, W, Manohar, S, and Vogel, C. "Identification and quantification of K63-ubiquitinated proteins in neuronal cells by high-resolution mass spectrometry." In Analysis of Post-Translational Modifications and Proteolysis in Neuroscience, 111-125. New York, NY: Humana Press, 2016. (Chapter) Full Text

Silva, GM, and Vogel, C. "Quantifying gene expression: the importance of being subtle." Molecular Systems Biology 12, no. 10 (October 2016): 885-885. Full Text

da Costa, JP, Vitorino, R, Silva, GM, Vogel, C, Duarte, AC, and Rocha-Santos, T. "A synopsis on aging—Theories, mechanisms and future prospects." Ageing Research Reviews 29 (August 2016): 90-112. Full Text

Toledo, RA, Qin, Y, Cheng, Z-M, Gao, Q, Iwata, S, Silva, GM, Prasad, ML, Ocal, IT, Rao, S, Aronin, N, Barontini, M, Bruder, J, Reddick, RL, Chen, Y, Aguiar, RCT, and Dahia, PLM. "Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas." Clinical Cancer Research 22, no. 9 (May 1, 2016): 2301-2310. Full Text

Silva, GM, and Vogel, C. "Mass spectrometry analysis of K63-ubiquitinated targets in response to oxidative stress." Data in Brief 4 (September 2015): 130-134. Full Text

Silva, GM, Finley, D, and Vogel, C. "K63 polyubiquitination is a new modulator of the oxidative stress response." Nature Structural & Molecular Biology 22, no. 2 (January 26, 2015): 116-123. Full Text

Tchourine, K, Poultney, CS, Wang, L, Silva, GM, Manohar, S, Mueller, CL, Bonneau, R, and Vogel, C. "One third of dynamic protein expression profiles can be predicted by a simple rate equation." Mol. BioSyst. 10, no. 11 (2014): 2850-2862. Full Text

Demasi, M, Netto, LES, Silva, GM, Hand, A, de Oliveira, CLP, Bicev, RN, Gozzo, F, Barros, MH, Leme, JMM, and Ohara, E. "Redox regulation of the proteasome via S-glutathionylation." Redox Biology 2 (2014): 44-51. Full Text

Malvezzi, A, Higa, PM, Amaral, AT-D, Silva, GM, Gozzo, FC, Ferro, ES, Castro, LM, de Rezende, L, Monteiro, G, and Demasi, M. "The Cysteine-Rich Protein Thimet Oligopeptidase as a Model of the Structural Requirements for S-glutathiolation and Oxidative Oligomerization." Edited by P Csermely. PLoS ONE 7, no. 6 (June 25, 2012): e39408-e39408. Full Text

Silva, GM, Netto, LES, Simões, V, Santos, LFA, Gozzo, FC, Demasi, MAA, Oliveira, CLP, Bicev, RN, Klitzke, CF, Sogayar, MC, and Demasi, M. "Redox Control of 20S Proteasome Gating." Antioxidants & Redox Signaling 16, no. 11 (June 2012): 1183-1194. Full Text

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