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Evolutionary, Ecological and Agricultural Functional Genomics
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CV  /  Profile

      Carrie F. Olson-Manning
      Research Fellow
      Department of Biology
      Duke University
      Box 90338
      Durham, NC 27708
      Ph: 919-668-6590
      Fax: 919-660-7293
      email: carrie.olson[@]duke.edu

POSTDOCS
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GRADUATE STUDENTS
Rose
Rose Keith
Ray
Cheng-Ruei Lee
Carrie
Carrie Olson-Manning
Cathy
Cathy Rushworth
Maggie
Maggie Wagner
TECHNICIANS
Kathy
Kathy Springer Ghattas


DEGREES
B.S. Genetics and Evolution (2003) Graduated Summa Cum Laude, Highest Honors
Title: The Effect of Random Amino Acid Replacement on Function and Fitness
RESEARCH INTERESTS

I study the molecular basis of natural selection. While statistical methods of sequence variation can detect a signature of selection, an understanding of the molecular mechanism that selection acts through requires biochemical experimentation.

Novel biochemical function and protein promiscuity

Virtually all of the interactions in living cells are specific, including interactions between transcription factors and DNA binding sites, ligands and receptors, and enzymes and substrates. Yet, one of the most important and understudied questions in evolutionary biology is how complex, specific interactions evolve. My current focus includes understanding how protein promiscuity contributes to the evolution of novel phenotypes.

The evolution of biochemical pathways

Understanding how evolutionary forces act on natural variation in biochemical pathways is of prime interest to molecular evolution. While theory predicts that upstream enzymes in a pathway might control the amount a pathway can produce and therefore the place that evolution will act, we are interested in testing this empirically.

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RECENT PUBLICATIONS

    Olson-Manning, C.F., Lee, C.R., Rausher, M.D., Mitchell-Olds, S.T., The evolution of flux control in the glucosinolate pathway. 2013 Molecular Biology and Evolution 30:14-23

    Prasad, V.S.K.*, Song, B.*, Olson-Manning, C.F.* et al., A novel gain of function polymorphism controlling complex traits and fitness in nature. 2012. Science 337:1081-1084

    * These authors contributed equally

    Olson-Manning, C.F., Wagner, M.R., Mitchell-Olds, T., Adaptive evolution: evaluating empirical support for theoretical predictions. 2012. Nature Reviews Genetics 13: 867-877

See CV (click here) for complete reference list

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