Welcome to the Magwene lab in the Department of Biology at Duke University.
Research in our lab focuses on the following areas:
Genomic research in our lab is focused on characterizing genetic variation within and between species and exploring the consequences of that variation in terms of genetic networks and cellular phenotypes. We utilize a variety of standard and high-throughput molecular biology techniques to tackle these problems. Our primary model system is the budding yeast, Saccharomyces cerevisiae, as well as other hemiascomycete fungi.
Computational and biostatistical research in the Magwene lab is focused on developing analytical and algorithmic approaches for addressing problems in systems biology and evolutionary biology. Current projects focus on estimating genetic regulatory networks from high-throughput data (e.g. microarrays, ChIP-chip experiments), time series analysis of gene expression, and using phylogenetic approaches to design multi-species microarrays for comparative studies.
If you're interested in participating in interdisciplinary biological research with an emphasis on understanding the relationship between genotype and phenotype than I encourage you to contact me.