Overview
The Silva lab (sites.duke.edu/silvalab) investigates the underlying mechanisms by which gene expression is regulated at the transcriptional and translational levels in response to stress. We are also interested in understanding how the small protein modifier ubiquitin controls the dynamics of protein synthesis and degradation during stress, which are critical for physiology as proteins are the molecular effectors of the cell. Finally, we are elucidating mechanisms by which mutations to …
Current Appointments & Affiliations
Associate Professor of Biology
·
2024 - Present
Biology,
Trinity College of Arts & Sciences
Assistant Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Recent Publications
Localized K63 Ubiquitin Signaling Is Regulated by VCP/p97 During Oxidative Stress.
Journal Article Mol Cell Proteomics · March 2025 Under stress conditions, cells reprogram their molecular machineries to mitigate damage and promote survival. Ubiquitin signaling is globally increased during oxidative stress, controlling protein fate and supporting stress defenses at several subcellular ... Full text Link to item CiteRedox control of the deubiquitinating enzyme Ubp2 regulates translation during stress.
Journal Article The Journal of biological chemistry · November 2024 Protein ubiquitination is essential to govern cells' ability to cope with harmful environments by regulating many aspects of protein dynamics from synthesis to degradation. As important as the ubiquitination process, the reversal of ubiquitin chains mediat ... Full text CiteThe ubiquitin conjugase Rad6 mediates ribosome pausing during oxidative stress.
Journal Article Cell reports · November 2023 Oxidative stress causes K63-linked ubiquitination of ribosomes by the E2 ubiquitin conjugase Rad6. How Rad6-mediated ubiquitination of ribosomes affects translation, however, is unclear. We therefore perform Ribo-seq and Disome-seq in Saccharomyces cerevis ... Full text CiteRecent Grants
Tri-Institutional Molecular Mycology and Pathogenesis Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029Stalling cancer at the ribosome
ResearchCollaborator · Awarded by V Foundation for Cancer Research · 2025 - 2028Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2022 - 2027View All Grants
Education, Training & Certifications
University of Sao Paulo (Brazil) ·
2010
Ph.D.
University of Sao Paulo (Brazil) ·
2004
B.Sc.